Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q96FZ2 | HMCES | Abasic site processing protein HMCES … | Homo sapiens (Human) | 354 aa |
Protein Details: Q96FZ2 (HMCES)
Protein Information
| Accession | Q96FZ2 |
|---|---|
| Protein Names | Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) |
| Gene Symbol | HMCES |
| Organism | Homo sapiens (Human) |
| Length | 354 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MCGRTSCHLP11RDVLTRACAY21QDRRGQQRLP31EWRDPDKYCP41SYNKSPQSNS
51-10051PVLLSRLHFE61KDADSSERII71APMRWGLVPS81WFKESDPSKL91QFNTTNCRSD
101-150101TVMEKRSFKV111PLGKGRRCVV121LADGFYEWQR131CQGTNQRQPY141FIYFPQIKTE
151-200151KSGSIGAADS161PENWEKVWDN171WRLLTMAGIF181DCWEPPEGGD191VLYSYTIITV
201-250201DSCKGLSDIH211HRMPAILDGE221EAVSKWLDFG231EVSTQEALKL241IHPTENITFH
251-300251AVSSVVNNSR261NNTPECLAPV271DLVVKKELRA281SGSSQRMLQW291LATKSPKKED
301-350301SKTPQKEESD311VPQWSSQFLQ321KSPLPTKRGT331AGLLEQWLKR341EKEEEPVAKR
351-354351PYSQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 2 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.02
|
|
| 7 | SOS response associated peptidase-like | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.02
|
|
| 18 | SOS response associated peptidase-like | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.86
|
|
| 39 | SOS response associated peptidase-like | - | - |
Deep-Palm: 0.53
|
|
| 97 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.61
|
|
| 118 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.88
|
|
| 131 | - | - | - |
Deep-Palm: 0.27
|
|
| 182 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.16
|
|
| 203 | - | - | - |
Deep-Palm: 0.59
|
|
| 266 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
2
LNCaP
Specificity: 0.400
2/2 (100.0%)
2
PC3
Specificity: 0.400
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 68 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 98 | R → C | 0.008130 | SNP | Missense Mutation | THYM |
| 143 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 253 | S → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 290 | W → C | 0.001969 | SNP | Missense Mutation | LGG |
| 350 | R → C | 0.002506 | SNP | Missense Mutation | COAD |