Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q96LJ7 | DHRS1 | Dehydrogenase/reductase SDR family member 1 … | Homo sapiens (Human) | 313 aa |
Protein Details: Q96LJ7 (DHRS1)
Protein Information
| Accession | Q96LJ7 |
|---|---|
| Protein Names | Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1) |
| Gene Symbol | DHRS1 |
| Organism | Homo sapiens (Human) |
| Length | 313 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAPMNGQVC11VVTGASRGIG21RGIALQLCKA31GATVYITGRH41LDTLRVVAQE
51-10051AQSLGGQCVP61VVCDSSQESE71VRSLFEQVDR81EQQGRLDVLV91NNAYAGVQTI
101-150101LNTRNKAFWE111TPASMWDDIN121NVGLRGHYFC131SVYGARLMVP141AGQGLIVVIS
151-200151SPGSLQYMFN161VPYGVGKAAC171DKLAADCAHE181LRRHGVSCVS191LWPGIVQTEL
201-250201LKEHMAKEEV211LQDPVLKQFK221SAFSSAETTE231LSGKCVVALA241TDPNILSLSG
251-300251KVLPSCDLAR261RYGLRDVDGR271PVQDYLSLSS281VLSHVSGLGW291LASYLPSFLR
301-313301VPKWIIALYT311SKF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | NAD(P)-binding domain superfamily DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.37
|
|
| 28 | DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 NAD(P)-binding domain superfamily Short-chain dehydrogenase/reductase SDR | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.98
|
|
| 58 | - | - | - |
Deep-Palm: 0.97
|
|
| 63 | - | - | - |
Deep-Palm: 0.94
|
|
| 130 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.73
|
|
| 170 | - | - | - |
Deep-Palm: 0.93
|
|
| 177 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 188 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.97
|
|
| 235 | - |
HeLa
(37611173)
|
LNCaP
(31251020)
|
Deep-Palm: 0.96
|
|
| 256 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
LNCaP
Specificity: 0.667
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 18 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 261 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 275 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 300 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |