Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q96RQ1 | ERGIC2 | Endoplasmic reticulum-Golgi intermediate compartment protein … | Homo sapiens (Human) | 377 aa |
Protein Details: Q96RQ1 (ERGIC2)
Protein Information
| Accession | Q96RQ1 |
|---|---|
| Protein Names | Endoplasmic reticulum-Golgi intermediate compartment protein 2 |
| Gene Symbol | ERGIC2 |
| Organism | Homo sapiens (Human) |
| Length | 377 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 26111759 29575903 31251020 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRRLNRKKTL11SLVKELDAFP21KVPESYVETS31ASGGTVSLIA41FTTMALLTIM
51-10051EFSVYQDTWM61KYEYEVDKDF71SSKLRINIDI81TVAMKCQYVG91ADVLDLAETM
101-150101VASADGLVYE111PTVFDLSPQQ121KEWQRMLQLI131QSRLQEEHSL141QDVIFKSAFK
151-200151STSTALPPRE161DDSSQSPNAC171RIHGHLYVNK181VAGNFHITVG191KAIPHPRGHA
201-250201HLAALVNHES211YNFSHRIDHL221SFGELVPAII231NPLDGTEKIA241IDHNQMFQYF
251-300251ITVVPTKLHT261YKISADTHQF271SVTERERIIN281HAAGSHGVSG291IFMKYDLSSL
301-350301MVTVTEEHMP311FWQFFVRLCG321IVGGIFSTTG331MLHGIGKFIV341EIICCRFRLG
351-377351SYKPVNSVPF361EDGHTDNHLP371LLENNTH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 86 | - | - | - |
Deep-Palm: 0.61
|
|
| 170 | - | - | - |
Deep-Palm: 0.58
|
|
| 319 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.25
|
|
| 344 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.65
|
|
| 345 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.64
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.300
3
LNCaP
Specificity: 0.273
3/3 (100.0%)
2
Primary T cell
Specificity: 0.182
2/2 (100.0%)
2
HeLa cell
Specificity: 0.182
2/2 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
heart
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 34 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 249 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 277 | R → C | 0.001969 | SNP | Missense Mutation | LGG |