Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q96RQ3 MCCC1; MCCA Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial … Homo sapiens (Human) 725 aa

Protein Details: Q96RQ3 (MCCC1)

Protein Information
Accession Q96RQ3
Protein Names Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)
Gene Symbol MCCC1; MCCA
Organism Homo sapiens (Human)
Length 725 aa
Isoforms No isoforms
Related PMIDs 29733200 31251020 33636221
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.545
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
6
HAP1 cells
Specificity: 0.545
6/10 (60.0%)
4
LNCaP cells
Specificity: 0.364
4/46 (8.7%)
1
Liver membrane
Specificity: 0.091
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAAASAVSVL11LVAAERNRWH21RLPSLLLPPR31TWVWRQRTMK41YTTATGRNIT
51-10051KVLIANRGEI61ACRVMRTAKK71LGVQTVAVYS81EADRNSMHVD91MADEAYSIGP
101-150101APSQQSYLSM111EKIIQVAKTS121AAQAIHPGCG131FLSENMEFAE141LCKQEGIIFI
151-200151GPPPSAIRDM161GIKSTSKSIM171AAAGVPVVEG181YHGEDQSDQC191LKEHARRIGY
201-250201PVMIKAVRGG211GGKGMRIVRS221EQEFQEQLES231ARREAKKSFN241DDAMLIEKFV
251-300251DTPRHVEVQV261FGDHHGNAVY271LFERDCSVQR281RHQKIIEEAP291APGIKSEVRK
301-350301KLGEAAVRAA311KAVNYVGAGT321VEFIMDSKHN331FCFMEMNTRL341QVEHPVTEMI
351-400351TGTDLVEWQL361RIAAGEKIPL371SQEEITLQGH381AFEARIYAED391PSNNFMPVAG
401-450401PLVHLSTPRA411DPSTRIETGV421RQGDEVSVHY431DPMIAKLVVW441AADRQAALTK
451-500451LRYSLRQYNI461VGLHTNIDFL471LNLSGHPEFE481AGNVHTDFIP491QHHKQLLLSR
501-550501KAAAKESLCQ511AALGLILKEK521AMTDTFTLQA531HDQFSPFSSS541SGRRLNISYT
551-600551RNMTLKDGKN561NVAIAVTYNH571DGSYSMQIED581KTFQVLGNLY591SEGDCTYLKC
601-650601SVNGVASKAK611LIILENTIYL621FSKEGSIEID631IPVPKYLSSV641SSQETQGGPL
651-700651APMTGTIEKV661FVKAGDKVKA671GDSLMVMIAM681KMEHTIKSPK691DGTVKKVFYR
701-725701EGAQANRHTP711LVEFEEEESD721KRESE
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
62 Prediction (High) - -
142 Prediction (Low) - -
276 Prediction (Medium) - -
509 CYSMODDB SWISSPALM DBPTM Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
66 R → C 0.001887 SNP Missense Mutation UCEC
107 Y → C 0.005435 SNP Missense Mutation ESCA
149 F → C 0.001887 SNP Missense Mutation UCEC
200 Y → C 0.003559 SNP Missense Mutation KIRP
276 C → F 0.001764 SNP Missense Mutation LUAD
323 F → C 0.001887 SNP Missense Mutation UCEC