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UniProt ID	Gene Symbol	Protein Name	Organism	Length	Action
Q96RQ3	MCCC1	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial …	Homo sapiens (Human)	725 aa

Protein Details: Q96RQ3 (MCCC1)

Protein Information

Accession	Q96RQ3
Protein Names	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)
Gene Symbol	MCCC1
Organism	Homo sapiens (Human)
Length	725 aa
Isoforms	No isoforms
Related PMIDs	33636221
Database Sources	CysModDB dbPTM SwissPalm

These studies detected palmitoylation of this protein in the samples.

Protein Sequence

Types:
Experimental Database High Prediction Non-palmitylated Cys

1-501MAAASAVSVL11LVAAERNRWH21RLPSLLLPPR31TWVWRQRTMK41YTTATGRNIT

51-10051KVLIANRGEI61ACRVMRTAKK71LGVQTVAVYS81EADRNSMHVD91MADEAYSIGP

101-150101APSQQSYLSM111EKIIQVAKTS121AAQAIHPGCG131FLSENMEFAE141LCKQEGIIFI

151-200151GPPPSAIRDM161GIKSTSKSIM171AAAGVPVVEG181YHGEDQSDQC191LKEHARRIGY

201-250201PVMIKAVRGG211GGKGMRIVRS221EQEFQEQLES231ARREAKKSFN241DDAMLIEKFV

251-300251DTPRHVEVQV261FGDHHGNAVY271LFERDCSVQR281RHQKIIEEAP291APGIKSEVRK

301-350301KLGEAAVRAA311KAVNYVGAGT321VEFIMDSKHN331FCFMEMNTRL341QVEHPVTEMI

351-400351TGTDLVEWQL361RIAAGEKIPL371SQEEITLQGH381AFEARIYAED391PSNNFMPVAG

401-450401PLVHLSTPRA411DPSTRIETGV421RQGDEVSVHY431DPMIAKLVVW441AADRQAALTK

451-500451LRYSLRQYNI461VGLHTNIDFL471LNLSGHPEFE481AGNVHTDFIP491QHHKQLLLSR

501-550501KAAAKESLCQ511AALGLILKEK521AMTDTFTLQA531HDQFSPFSSS541SGRRLNISYT

551-600551RNMTLKDGKN561NVAIAVTYNH571DGSYSMQIED581KTFQVLGNLY591SEGDCTYLKC

601-650601SVNGVASKAK611LIILENTIYL621FSKEGSIEID631IPVPKYLSSV641SSQETQGGPL

651-700651APMTGTIEKV661FVKAGDKVKA671GDSLMVMIAM681KMEHTIKSPK691DGTVKKVFYR

701-725701EGAQANRHTP711LVEFEEEESD721KRESE

Palmitoylation Sites Details

Position	Database	Domains	Literature (PMID/Cell-Tissue)	Mass(PMID/Cell-Tissue)	Prediction Scores
62		-	-	-	GPS-Palm: 0.93 Deep-Palm: 0.97
129		-	-	-	Deep-Palm: 0.92
142		-	-	-	GPS-Palm: 0.65 Deep-Palm: 0.89
190		-	-	-	Deep-Palm: 0.89
276		-	-	-	GPS-Palm: 0.83 Deep-Palm: 0.59
332		-	-	-	Deep-Palm: 0.36
509	SWISSPALM DBPTM CYSMODDB	-	-	-	GPS-Palm: 0.96 Deep-Palm: 0.98
595		-	-	-	Deep-Palm: 0.80
600		-	-	-	Deep-Palm: 0.89

Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)

Tissue/Cell Line Expression

Literature Data - Tissue/Cell Line Expression

Tissue Specificity Index (TSI): 1.000

heart

Specificity: 1.000

1/1 (100.0%)

Mass Spectrometry Data - Tissue/Cell Line Expression

Tissue Specificity Index (TSI): 0.000

Palmitoylation Distribution by Study and Tissue/Cell Line

Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.

Conservation score for cysteine

PhyloP for Cysteine

PhastCons Conservation Scores for Cysteine

TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position	Amino Acid Change	Frequency	Type	Function	Cancer Type
66	R → C	0.001887	SNP	Missense Mutation	UCEC
107	Y → C	0.005435	SNP	Missense Mutation	ESCA
149	F → C	0.001887	SNP	Missense Mutation	UCEC
200	Y → C	0.003559	SNP	Missense Mutation	KIRP
276	C → F	0.001764	SNP	Missense Mutation	LUAD
323	F → C	0.001887	SNP	Missense Mutation	UCEC