Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q99497 | PARK7 | Parkinson disease protein 7 (Maillard … | Homo sapiens (Human) | 189 aa |
Protein Details: Q99497 (PARK7)
Protein Information
| Accession | Q99497 |
|---|---|
| Protein Names | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) |
| Gene Symbol | PARK7 |
| Organism | Homo sapiens (Human) |
| Length | 189 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASKRALVIL11AKGAEEMETV21IPVDVMRRAG31IKVTVAGLAG41KDPVQCSRDV
51-10051VICPDASLED61AKKEGPYDVV71VLPGGNLGAQ81NLSESAAVKE91ILKEQENRKG
101-150101LIAAICAGPT111ALLAHEIGFG121SKVTTHPLAK131DKMMNGGHYT141YSENRVEKDG
151-189151LILTSRGPGT161SFEFALAIVE171ALNGKEVAAQ181VKAPLVLKD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 46 | DBPTM SWISSPALM | DJ-1/PfpI family DJ-1/PfpI Class I glutamine amidotransferase-like Protein/nucleic acid deglycase | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.70
Deep-Palm: 0.98
|
| 53 | SWISSPALM DBPTM CYSMODDB | DJ-1/PfpI family | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.94
|
| 106 | SWISSPALM DBPTM CYSMODDB | DJ-1/PfpI family | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.87
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
1
LNCaP
Specificity: 0.083
1/1 (100.0%)
1
U937 cell
Specificity: 0.083
1/1 (100.0%)
1
293T cell
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.083
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 145 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |