Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q99805 TM9SF2 Transmembrane 9 superfamily member 2 … Homo sapiens (Human) 663 aa

Protein Details: Q99805 (TM9SF2)

Protein Information
AccessionQ99805
Protein NamesTransmembrane 9 superfamily member 2 (p76)
Gene SymbolTM9SF2
OrganismHomo sapiens (Human)
Length663 aa
IsoformsNo isoforms
Related PMIDs 26111759 29733200 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MSARLPVLSP11PRWPRLLLLS21LLLLGAVPGP31RRSGAFYLPG41LAPVNFCDEE
51-10051KKSDECKAEI61ELFVNRLDSV71ESVLPYEYTA81FDFCQASEGK91RPSENLGQVL
101-150101FGERIEPSPY111KFTFNKKETC121KLVCTKTYHT131EKAEDKQKLE141FLKKSMLLNY
151-200151QHHWIVDNMP161VTWCYDVEDG171QRFCNPGFPI181GCYITDKGHA191KDACVISSDF
201-250201HERDTFYIFN211HVDIKIYYHV221VETGSMGARL231VAAKLEPKSF241KHTHIDKPDC
251-300251SGPPMDISNK261ASGEIKIAYT271YSVSFEEDDK281IRWASRWDYI291LESMPHTHIQ
301-350301WFSIMNSLVI311VLFLSGMVAM321IMLRTLHKDI331ARYNQMDSTE341DAQEEFGWKL
351-400351VHGDIFRPPR361KGMLLSVFLG371SGTQILIMTF381VTLFFACLGF391LSPANRGALM
401-450401TCAVVLWVLL411GTPAGYVAAR421FYKSFGGEKW431KTNVLLTSFL441CPGIVFADFF
451-500451IMNLILWGEG461SSAAIPFGTL471VAILALWFCI481SVPLTFIGAY491FGFKKNAIEH
501-550501PVRTNQIPRQ511IPEQSFYTKP521LPGIIMGGIL531PFGCIFIQLF541FILNSIWSHQ
551-600551MYYMFGFLFL561VFIILVITCS571EATILLCYFH581LCAEDYHWQW591RSFLTSGFTA
601-650601VYFLIYAVHY611FFSKLQITGT621ASTILYFGYT631MIMVLIFFLF641TGTIGFFACF
651-663651WFVTKIYSVV661KVD
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
47 - - -
Deep-Palm: 0.90
56 - - -
Deep-Palm: 0.59
84 - -
LNCaP (31251020)
Deep-Palm: 0.90
120 SWISSPALM DBPTM CYSMODDB Endomembrane protein 70 - -
GPS-Palm: 0.87
Deep-Palm: 0.60
124 SWISSPALM DBPTM CYSMODDB Endomembrane protein 70 - -
GPS-Palm: 0.79
Deep-Palm: 0.54
164 - - -
Deep-Palm: 0.02
174 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
cerebral cortex (36430497)
GPS-Palm: 0.67
Deep-Palm: 0.19
182 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
cerebral cortex (36430497)
GPS-Palm: 0.73
Deep-Palm: 0.38
194 - - -
Deep-Palm: 0.15
250 - - -
Deep-Palm: 0.32
387 - - -
GPS-Palm: 0.87
Deep-Palm: 0.80
402 - - -
GPS-Palm: 0.76
Deep-Palm: 0.95
441 - - -
Deep-Palm: 0.65
479 - - -
GPS-Palm: 0.70
Deep-Palm: 0.96
534 - - -
GPS-Palm: 0.79
Deep-Palm: 0.36
569 - - -
Deep-Palm: 0.23
577 - - -
Deep-Palm: 0.07
582 - - -
Deep-Palm: 0.09
649 - - -
Deep-Palm: 0.08
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
2
LNCaP
Specificity: 0.286
2/2 (100.0%)
2
Primary T cell
Specificity: 0.286
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.143
1/1 (100.0%)
1
PC3
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Cerebral Cortex (Mass)
Specificity: 0.143
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
422 Y → C 0.002288 SNP Missense Mutation STAD
479 C → Y 0.002506 SNP Missense Mutation COAD