Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q99943 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51) … | Homo sapiens (Human) | 283 aa |
Protein Details: Q99943 (AGPAT1)
Protein Information
| Accession | Q99943 |
|---|---|
| Protein Names | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 1) (1-AGP acyltransferase 1) (1-AGPAT 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) (Protein G15) |
| Gene Symbol | AGPAT1 |
| Organism | Homo sapiens (Human) |
| Length | 283 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 26111759 29733200 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDLWPGAWML11LLLLFLLLLF21LLPTLWFCSP31SAKYFFKMAF41YNGWILFLAV
51-10051LAIPVCAVRG61RNVENMKILR71LMLLHIKYLY81GIRVEVRGAH91HFPPSQPYVV
101-150101VSNHQSSLDL111LGMMEVLPGR121CVPIAKRELL131WAGSAGLACW141LAGVIFIDRK
151-200151RTGDAISVMS161EVAQTLLTQD171VRVWVFPEGT181RNHNGSMLPF191KRGAFHLAVQ
201-250201AQVPIVPIVM211SSYQDFYCKK221ERRFTSGQCQ231VRVLPPVPTE241GLTPDDVPAL
251-283251ADRVRHSMLT261VFREISTDGR271GGGDYLKKPG281GGG
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 28 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.98
|
|
| 56 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.91
|
|
| 121 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.98
|
|
| 139 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.97
|
|
| 218 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.60
|
|
| 229 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.81
Deep-Palm: 0.84
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
4
LNCaP
Specificity: 0.308
4/4 (100.0%)
4
Jurkat T cell
Specificity: 0.308
4/4 (100.0%)
3
PC3
Specificity: 0.231
3/3 (100.0%)
1
293T cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Cerebral Cortex (Mass)
Specificity: 0.077
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 61 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 70 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 120 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 121 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 151 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 192 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 222 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 223 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 223 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |