Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9BSY9 | DESI2 | Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating … | Homo sapiens (Human) | 194 aa |
Protein Details: Q9BSY9 (DESI2)
Protein Information
| Accession | Q9BSY9 |
|---|---|
| Protein Names | Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2) |
| Gene Symbol | DESI2 |
| Organism | Homo sapiens (Human) |
| Length | 194 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGANQLVVLN11VYDMYWMNEY21TSSIGIGVFH31SGIEVYGREF41AYGGHPYPFS
51-10051GIFEISPGNA61SELGETFKFK71EAVVLGSTDF81LEDDIEKIVE91ELGKEYKGNA
101-150101YHLMHKNCNH111FSSALSEILC121GKEIPRWINR131LAYFSSCIPF141LQSCLPKEWL
151-194151TPAALQSSVS161QELQDELEEA171EDAAASASVA181STAAGSRPGR191HTKL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 108 | - | - | - |
Deep-Palm: 0.28
|
|
| 120 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.25
|
|
| 137 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.88
|
|
| 144 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.91
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
Jurkat T cell
Specificity: 0.750
3/3 (100.0%)
1
HUVECs
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 144 | C → F | 0.001887 | SNP | Missense Mutation | UCEC |