Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9BTU6 | PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha (EC … | Homo sapiens (Human) | 479 aa |
Protein Details: Q9BTU6 (PI4K2A)
Protein Information
| Accession | Q9BTU6 |
|---|---|
| Protein Names | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) |
| Gene Symbol | PI4K2A |
| Organism | Homo sapiens (Human) |
| Length | 479 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 22496122 24357059 26111759 31251020 31382980 32651440 32944167 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDETSPLVSP11ERAQPPDYTF21PSGSGAHFPQ31VPGGAVRVAA41AAGSGPSPPG
51-10051SPGHDRERQP61LLDRARGAAA71QGQTQTVAAQ81AQALAAQAAA91AAHAAQAHRE
101-150101RNEFPEDPEF111EAVVRQAELA121IERCIFPERI131YQGSSGSYFV141KDPQGRIIAV
151-200151FKPKNEEPYG161HLNPKWTKWL171QKLCCPCCFG181RDCLVLNQGY191LSEAGASLVD
201-250201QKLELNIVPR211TKVVYLASET221FNYSAIDRVK231SRGKRLALEK241VPKVGQRFNR
251-300251IGLPPKVGSF261QLFVEGYKDA271DYWLRRFEAE281PLPENTNRQL291LLQFERLVVL
301-350301DYIIRNTDRG311NDNWLIKYDC321PMDSSSSRDT331DWVVVKEPVI341KVAAIDNGLA
351-400351FPLKHPDSWR361AYPFYWAWLP371QAKVPFSQEI381KDLILPKISD391PNFVKDLEED
401-450401LYELFKKDPG411FDRGQFHKQI421AVMRGQILNL431TQALKDNKSP441LHLVQMPPVI
451-479451VETARSHQRS461SSESYTQSFQ471SRKPFFSWW
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 124 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.91
Deep-Palm: 0.96
|
| 174 | DBPTM | Phosphatidylinositol 3- and 4-kinase | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.24
|
| 175 | DBPTM | Phosphatidylinositol 3- and 4-kinase | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.34
|
| 177 | DBPTM | Phosphatidylinositol 3- and 4-kinase | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.45
|
| 178 | DBPTM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.54
|
| 183 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.88
Deep-Palm: 0.90
|
|
| 320 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.08
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
8
Jurkat T cell
Specificity: 0.320
8/8 (100.0%)
4
LNCaP
Specificity: 0.160
4/4 (100.0%)
4
PC3
Specificity: 0.160
4/4 (100.0%)
3
Primary T cell
Specificity: 0.120
3/3 (100.0%)
1
U937 cell
Specificity: 0.040
1/1 (100.0%)
1
EC cell
Specificity: 0.040
1/1 (100.0%)
1
heart
Specificity: 0.040
1/1 (100.0%)
1
HUVECs
Specificity: 0.040
1/1 (100.0%)
1
DU145 cell
Specificity: 0.040
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.040
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 181 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 183 | C → S | 0.002288 | SNP | Missense Mutation | STAD |
| 183 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | R → C | 0.002506 | SNP | Missense Mutation | COAD |