Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9BTU6 | PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha (EC … | Homo sapiens (Human) | 479 aa |
Protein Details: Q9BTU6 (PI4K2A)
Protein Information
| Accession | Q9BTU6 |
|---|---|
| Protein Names | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) |
| Gene Symbol | PI4K2A |
| Organism | Homo sapiens (Human) |
| Length | 479 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 22496122 24357059 26111759 29575903 29733200 31251020 31382980 32651440 32944167 33636221 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.549
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
39
LNCaP cells
Specificity: 0.549
39/46 (84.8%)
13
Jurkat T cells
Specificity: 0.183
13/25 (52.0%)
4
PC3 cells
Specificity: 0.056
4/4 (100.0%)
4
HAP1 cells
Specificity: 0.056
4/10 (40.0%)
3
T cells
Specificity: 0.042
3/4 (75.0%)
2
DU145 cells
Specificity: 0.028
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.028
2/2 (100.0%)
1
U937 cells
Specificity: 0.014
1/1 (100.0%)
1
HeLa cells
Specificity: 0.014
1/1 (100.0%)
1
Cerebral cortex
Specificity: 0.014
1/4 (25.0%)
1
Liver membrane
Specificity: 0.014
1/1 (100.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MDETSPLVSP11ERAQPPDYTF21PSGSGAHFPQ31VPGGAVRVAA41AAGSGPSPPG
51-10051SPGHDRERQP61LLDRARGAAA71QGQTQTVAAQ81AQALAAQAAA91AAHAAQAHRE
101-150101RNEFPEDPEF111EAVVRQAELA121IERCIFPERI131YQGSSGSYFV141KDPQGRIIAV
151-200151FKPKNEEPYG161HLNPKWTKWL171QKLCCPCCFG181RDCLVLNQGY191LSEAGASLVD
201-250201QKLELNIVPR211TKVVYLASET221FNYSAIDRVK231SRGKRLALEK241VPKVGQRFNR
251-300251IGLPPKVGSF261QLFVEGYKDA271DYWLRRFEAE281PLPENTNRQL291LLQFERLVVL
301-350301DYIIRNTDRG311NDNWLIKYDC321PMDSSSSRDT331DWVVVKEPVI341KVAAIDNGLA
351-400351FPLKHPDSWR361AYPFYWAWLP371QAKVPFSQEI381KDLILPKISD391PNFVKDLEED
401-450401LYELFKKDPG411FDRGQFHKQI421AVMRGQILNL431TQALKDNKSP441LHLVQMPPVI
451-479451VETARSHQRS461SSESYTQSFQ471SRKPFFSWW
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 124 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | - | 29575903 |
| 174 | DBPTM Prediction (High) | Phosphatidylinositol 3- and 4-kinase | - |
| 175 | DBPTM Prediction (High) | Phosphatidylinositol 3- and 4-kinase | - |
| 177 | DBPTM Prediction (High) | Phosphatidylinositol 3- and 4-kinase | - |
| 178 | DBPTM Prediction (High) | - | - |
| 183 | Prediction (Medium) | - | - |
| 320 | Experimental | Phosphatidylinositol 3- and 4-kinase | 29575903 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 181 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 183 | C → S | 0.002288 | SNP | Missense Mutation | STAD |
| 183 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | R → C | 0.002506 | SNP | Missense Mutation | COAD |