Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9BUF5 | TUBB6 | Tubulin beta-6 chain (Tubulin beta … | Homo sapiens (Human) | 446 aa |
Protein Details: Q9BUF5 (TUBB6)
Protein Information
| Accession | Q9BUF5 |
|---|---|
| Protein Names | Tubulin beta-6 chain (Tubulin beta class V) |
| Gene Symbol | TUBB6 |
| Organism | Homo sapiens (Human) |
| Length | 446 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MREIVHIQAG11QCGNQIGTKF21WEVISDEHGI31DPAGGYVGDS41ALQLERINVY
51-10051YNESSSQKYV61PRAALVDLEP71GTMDSVRSGP81FGQLFRPDNF91IFGQTGAGNN
101-150101WAKGHYTEGA111ELVDAVLDVV121RKECEHCDCL131QGFQLTHSLG141GGTGSGMGTL
151-200151LISKIREEFP161DRIMNTFSVM171PSPKVSDTVV181EPYNATLSVH191QLVENTDETY
201-250201CIDNEALYDI211CFRTLKLTTP221TYGDLNHLVS231ATMSGVTTSL241RFPGQLNADL
251-300251RKLAVNMVPF261PRLHFFMPGF271APLTSRGSQQ281YRALTVPELT291QQMFDARNMM
301-350301AACDPRHGRY311LTVATVFRGP321MSMKEVDEQM331LAIQSKNSSY341FVEWIPNNVK
351-400351VAVCDIPPRG361LKMASTFIGN371STAIQELFKR381ISEQFSAMFR391RKAFLHWFTG
401-446401EGMDEMEFTE411AESNMNDLVS421EYQQYQDATA431NDGEEAFEDE441EEEIDG
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | Tubulin/FtsZ, GTPase domain superfamily OS01G0282866 PROTEIN | - | - |
Deep-Palm: 0.03
|
|
| 124 | - | - | - |
Deep-Palm: 0.67
|
|
| 127 | - | - | - |
Deep-Palm: 0.65
|
|
| 129 | - | - | - |
Deep-Palm: 0.79
|
|
| 201 | - | - | - |
Deep-Palm: 0.13
|
|
| 211 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.16
|
|
| 303 | SWISSPALM DBPTM CYSMODDB | Tubulin C-terminal domain | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.70
|
| 354 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.81
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
HAP1 cell
Specificity: 0.500
1/1 (100.0%)
1
U937 cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 146 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 153 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 201 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 241 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 244 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 251 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 303 | C → C | 0.001887 | SNP | Silent | UCEC |
| 318 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |