Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9BWD1-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) … | Homo sapiens (Human) | 426 aa |
Protein Details: Q9BWD1-2 (ACAT2)
Protein Information
| Accession | Q9BWD1-2 |
|---|---|
| Protein Names | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase) |
| Gene Symbol | ACAT2 |
| Organism | Homo sapiens (Human) |
| Length | 426 aa |
| Isoforms | |
| Related PMIDs | 29575903 31251020 32944167 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGSHPVLRIW11GNRRATAASL21GRSGGRLSSP31RLLRVVAPTL41TFAQTSRCSF
51-10051NGALAAVPVQ61DLGSTVIKEV71LKRATVAPED81VSEVIFGHVL91AAGCGQNPVR
101-150101QASVGAGIPY111SVPAWSCQMI121CGSGLKAVCL131AVQSIGIGDS141SIVVAGGMEN
151-200151MSKAPHLAYL161RTGVKIGEMP171LTDSILCDGL181TDAFHNCHMG191ITAENVAKKW
201-250201QVSREDQDKV211AVLSQNRTEN221AQKAGHFDKE231IVPVLVSTRK241GLIEVKTDEF
251-300251PRHGSNIEAM261SKLKPYFLTD271GTGTVTPANA281SGINDGAAAV291VLMKKSEADK
301-350301RGLTPLARIV311SWSQVGVEPS321IMGIGPIPAI331KQAVTKAGWS341LEDVDIFEIN
351-400351EAFAAVSAAI361VKELGLNPEK371VNIEGGAIAL381GHPLGASGCR391ILVTLLHTLE
401-426401RMGRSRGVAA411LCIGGGMGIA421MCVQRE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 65 | - | - | - |
Deep-Palm: 0.97
|
|
| 88 | - | - | - |
Deep-Palm: 0.94
|
|
| 92 | - | - | - |
Deep-Palm: 0.90
|
|
| 94 | - |
HeLa
(29575903)
| - | - | |
| 100 | - | - | - |
Deep-Palm: 0.90
|
|
| 148 | - | - | - |
Deep-Palm: 0.33
|
|
| 158 | - | - | - |
Deep-Palm: 0.07
|
|
| 360 | - | - | - |
Deep-Palm: 0.98
|
|
| 383 | - | - | - |
Deep-Palm: 0.98
|
|
| 393 | - | - | - |
Deep-Palm: 0.04
|
|
| 422 | - | - | - |
GPS-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.444
4/4 (100.0%)
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
2
PC3
Specificity: 0.222
2/2 (100.0%)
1
HeLa cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 148 | C → S | 0.002747 | SNP | Missense Mutation | LIHC |
| 158 | C → G | 0.001887 | SNP | Missense Mutation | UCEC |
| 221 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 237 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 377 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 377 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 65* | C → ? | 0.002288 | SNP | Nonsense Mutation | STAD |