Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9BX67 | JAM3 | Junctional adhesion molecule C (JAM-C) … | Homo sapiens (Human) | 310 aa |
Protein Details: Q9BX67 (JAM3)
Protein Information
| Accession | Q9BX67 |
|---|---|
| Protein Names | Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] |
| Gene Symbol | JAM3 |
| Organism | Homo sapiens (Human) |
| Length | 310 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MALRRPPRLR11LCARLPDFFL21LLLFRGCLIG31AVNLKSSNRT41PVVQEFESVE
51-10051LSCIITDSQT61SDPRIEWKKI71QDEQTTYVFF81DNKIQGDLAG91RAEILGKTSL
101-150101KIWNVTRRDS111ALYRCEVVAR121NDRKEIDEIV131IELTVQVKPV141TPVCRVPKAV
151-200151PVGKMATLHC161QESEGHPRPH171YSWYRNDVPL181PTDSRANPRF191RNSSFHLNSE
201-250201TGTLVFTAVH211KDDSGQYYCI221ASNDAGSARC231EEQEMEVYDL241NIGGIIGGVL
251-300251VVLAVLALIT261LGICCAYRRG271YFINNKQDGE281SYKNPGKPDG291VNYIRTDEEG
301-310301DFRHKSSFVI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.96
|
|
| 27 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 53 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.65
|
|
| 115 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.77
|
|
| 144 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.90
|
|
| 160 | - | - | - |
Deep-Palm: 0.78
|
|
| 219 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.40
|
|
| 230 | - | - | - |
Deep-Palm: 0.06
|
|
| 264 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
| 265 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
Primary T cell
Specificity: 0.364
4/4 (100.0%)
4
Jurkat T cell
Specificity: 0.364
4/4 (100.0%)
1
heart
Specificity: 0.091
1/1 (100.0%)
1
HUVECs
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Cerebral Cortex (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 91 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 175 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 191 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 191 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |