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UniProt ID	Gene Symbol	Protein Name	Organism	Length	Action
Q9BZQ4	NMNAT2	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 …	Homo sapiens (Human)	307 aa

Protein Details: Q9BZQ4 (NMNAT2)

Protein Information

Accession	Q9BZQ4
Protein Names	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2)
Gene Symbol	NMNAT2
Organism	Homo sapiens (Human)
Length	307 aa
Isoforms	No isoforms
Related PMIDs	No related PMIDs
Database Sources	dbPTM SwissPalm

These studies detected palmitoylation of this protein in the samples.

Protein Sequence

Types:
Experimental Database High Prediction Non-palmitylated Cys

1-501MTETTKTHVI11LLACGSFNPI21TKGHIQMFER31ARDYLHKTGR41FIVIGGIVSP

51-10051VHDSYGKQGL61VSSRHRLIMC71QLAVQNSDWI81RVDPWECYQD91TWQTTCSVLE

101-150101HHRDLMKRVT111GCILSNVNTP121SMTPVIGQPQ131NETPQPIYQN141SNVATKPTAA

151-200151KILGKVGESL161SRICCVRPPV171ERFTFVDENA181NLGTVMRYEE191IELRILLLCG

201-250201SDLLESFCIP211GLWNEADMEV221IVGDFGIVVV231PRDAADTDRI241MNHSSILRKY

251-300251KNNIMVVKDD261INHPMSVVSS271TKSRLALQHG281DGHVVDYLSQ291PVIDYILKSQ

301-307301LYINASG

Palmitoylation Sites Details

Position	Database	Domains	Literature (PMID/Cell-Tissue)	Mass(PMID/Cell-Tissue)	Prediction Scores
14		Cytidyltransferase-like domain Nucleotidylyl transferase Rossmann-like alpha/beta/alpha sandwich fold Eukaryotic NMN adenylyltransferase	-	-	GPS-Palm: 0.73 Deep-Palm: 0.31
70		-	-	-	GPS-Palm: 0.87 Deep-Palm: 0.63
87		-	-	-	Deep-Palm: 0.05
96		-	-	-	Deep-Palm: 0.09
112		-	-	-	GPS-Palm: 0.68 Deep-Palm: 0.67
164	DBPTM SWISSPALM	-	-	-	GPS-Palm: 0.95 Deep-Palm: 0.97
165	DBPTM SWISSPALM	-	-	-	GPS-Palm: 0.93 Deep-Palm: 0.96
199		-	-	-	GPS-Palm: 0.76 Deep-Palm: 0.77
208		-	-	-	Deep-Palm: 0.93

Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)

Conservation score for cysteine

PhyloP for Cysteine

PhastCons Conservation Scores for Cysteine

TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position	Amino Acid Change	Frequency	Type	Function	Cancer Type
41	F → C	0.007299	SNP	Missense Mutation	READ
41	F → C	0.001887	SNP	Missense Mutation	UCEC
96	C → Y	0.006944	SNP	Missense Mutation	TGCT
165	C → R	0.002294	SNP	Missense Mutation	OV
165	C → G	0.002033	SNP	Missense Mutation	LUSC
176	V → Cfs*3	0.012195	INS	Frame Shift Ins	MESO
250	Y → delinsCKMAVN	0.001887	INS	In Frame Ins	UCEC