Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9C004 | SPRY4 | Protein sprouty homolog 4 (Spry-4) | Homo sapiens (Human) | 299 aa |
Protein Details: Q9C004 (SPRY4)
Protein Information
| Accession | Q9C004 |
|---|---|
| Protein Names | Protein sprouty homolog 4 (Spry-4) |
| Gene Symbol | SPRY4 |
| Organism | Homo sapiens (Human) |
| Length | 299 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEPPIPQSAP11LTPNSVMVQP21LLDSRMSHSR31LQHPLTILPI41DQVKTSHVEN
51-10051DYIDNPSLAL61TTGPKRTRGG71APELAPTPAR81CDQDVTHHWI91SFSGRPSSVS
101-150101SSSSTSSDQR111LLDHMAPPPV121ADQASPRAVR131IQPKVVHCQP141LDLKGPAVPP
151-200151ELDKHFLLCE161ACGKCKCKEC171ASPRTLPSCW181VCNQECLCSA191QTLVNYGTCM
201-250201CLVQGIFYHC211TNEDDEGSCA221DHPCSCSRSN231CCARWSFMGA241LSVVLPCLLC
251-299251YLPATGCVKL261AQRGYDRLRR271PGCRCKHTNS281VICKAASGDA291KTSRPDKPF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 81 | - | - | - |
Deep-Palm: 0.85
|
|
| 138 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.91
|
|
| 159 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.77
|
|
| 162 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.62
|
|
| 165 | - | - | - |
Deep-Palm: 0.19
|
|
| 167 | - | - | - |
Deep-Palm: 0.10
|
|
| 170 | - | - | - |
Deep-Palm: 0.05
|
|
| 179 | - | - | - |
Deep-Palm: 0.13
|
|
| 182 | - | - | - |
Deep-Palm: 0.13
|
|
| 186 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.10
|
|
| 188 | - | - | - |
Deep-Palm: 0.12
|
|
| 199 | - | - | - |
Deep-Palm: 0.05
|
|
| 201 | - | - | - |
Deep-Palm: 0.03
|
|
| 210 | - | - | - |
Deep-Palm: 0.02
|
|
| 219 | - | - | - |
Deep-Palm: 0.02
|
|
| 224 | - | - | - |
Deep-Palm: 0.03
|
|
| 226 | - | - | - |
Deep-Palm: 0.06
|
|
| 231 | - | - | - |
Deep-Palm: 0.22
|
|
| 232 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.12
|
|
| 247 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.96
|
|
| 250 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.97
|
|
| 257 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 273 | - | - | - |
Deep-Palm: 0.89
|
|
| 275 | - | - | - |
Deep-Palm: 0.88
|
|
| 283 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.81
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
CEM 174 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 26 | M → Cfs*18 | 0.002545 | DEL | Frame Shift Del | GBM |
| 95 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 159 | C → C | 0.002288 | SNP | Silent | STAD |
| 159 | C → C | 0.002020 | SNP | Silent | PRAD |
| 159 | C → C | 0.003460 | SNP | Silent | CESC |
| 165 | C → F | 0.019608 | SNP | Missense Mutation | CHOL |
| 219 | C → C | 0.002506 | SNP | Silent | COAD |
| 219 | C → C | 0.001887 | SNP | Silent | UCEC |
| 232 | C → C | 0.002506 | SNP | Silent | COAD |
| 270 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 274 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |