Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9DCL9 | Paics | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase … | Mus musculus (Mouse) | 425 aa |
Protein Details: Q9DCL9 (Paics)
Protein Information
| Accession | Q9DCL9 |
|---|---|
| Protein Names | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] |
| Gene Symbol | Paics |
| Organism | Mus musculus (Mouse) |
| Length | 425 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 29660268 34200797 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATAVVVNIG11KKLYEGKTKE21VYELLDTPGR31VLLQSKDQIT41AGNAARKNHL
51-10051EGKAAISNKI61TSCIFQLLQE71AGIKTAFTKK81CGETAFIAPQ91CEMIPIEWVC
101-150101RRIATGSFLK111RNPGVQEGYK121FYPPKVEMFF131KDDANNDPQW141SEEQLIAAKF
151-200151CFAGLVIGQT161EVDIMSHATQ171AIFEILEKSW181LPQDCTLVDM191KIEFGVDVTT
201-250201KEIVLADVID211NDSWRLWPSG221DRSQQKDKQS231YRDLKEVTPE241GLQMVKKNFE
251-300251WVADRVELLL261KSDSQCRVVV271LMGSTSDLGH281CEKIKKACGN291FGIPCELRVT
301-350301SAHKGPDETL311RIKAEYEGDG321IPTVFVSVAG331RSNGLGPVLS341GNTAYPVISC
351-400351PPITPDWGAQ361DVWSSLRLPS371GIGCSTILSP381EGSAQFAAQI391FGLNNHLVWA
401-425401KLRASILNTW411ISLKQADKKV421RQCNL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 63 | SWISSPALM DBPTM CYSMODDB | SAICAR synthetase |
Liver
(28526873)
|
Brain
(35358180)
|
Deep-Palm: 0.95
|
| 81 | - | - | - |
Deep-Palm: 0.78
|
|
| 91 | - | - | - |
Deep-Palm: 0.38
|
|
| 100 | - | - | - |
Deep-Palm: 0.30
|
|
| 151 | - | - | - |
Deep-Palm: 0.55
|
|
| 185 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.61
|
|
| 266 | - | - | - |
Deep-Palm: 0.95
|
|
| 281 | SWISSPALM DBPTM CYSMODDB | AIR carboxylase |
Liver
(28526873)
|
Brain
(35358180)
|
Deep-Palm: 0.87
|
| 288 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.93
|
|
| 295 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.96
|
|
| 350 | - | - | - |
Deep-Palm: 0.72
|
|
| 374 | - | - | - |
Deep-Palm: 0.95
|
|
| 423 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
Liver
Specificity: 0.190
4/4 (100.0%)
3
Brain
Specificity: 0.143
3/3 (100.0%)
2
Testis
Specificity: 0.095
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
12
Brain tissue (Mass)
Specificity: 0.571
12/56 (21.4%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.