Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9GZU1 | MCOLN1 | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient … | Homo sapiens (Human) | 580 aa |
Protein Details: Q9GZU1 (MCOLN1)
Protein Information
| Accession | Q9GZU1 |
|---|---|
| Protein Names | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) |
| Gene Symbol | MCOLN1 |
| Organism | Homo sapiens (Human) |
| Length | 580 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTAPAGPRGS11ETERLLTPNP21GYGTQAGPSP31APPTPPEEED41LRRRLKYFFM
51-10051SPCDKFRAKG61RKPCKLMLQV71VKILVVTVQL81ILFGLSNQLA91VTFREENTIA
101-150101FRHLFLLGYS111DGADDTFAAY121TREQLYQAIF131HAVDQYLALP141DVSLGRYAYV
151-200151RGGGDPWTNG161SGLALCQRYY171HRGHVDPAND181TFDIDPMVVT191DCIQVDPPER
201-250201PPPPPSDDLT211LLESSSSYKN221LTLKFHKLVN231VTIHFRLKTI241NLQSLINNEI
251-300251PDCYTFSVLI261TFDNKAHSGR271IPISLETQAH281IQECKHPSVF291QHGDNSFRLL
301-350301FDVVVILTCS311LSFLLCARSL321LRGFLLQNEF331VGFMWRQRGR341VISLWERLEF
351-400351VNGWYILLVT361SDVLTISGTI371MKIGIEAKNL381ASYDVCSILL391GTSTLLVWVG
401-450401VIRYLTFFHN411YNILIATLRV421ALPSVMRFCC431CVAVIYLGYC441FCGWIVLGPY
451-500451HVKFRSLSMV461SECLFSLING471DDMFVTFAAM481QAQQGRSSLV491WLFSQLYLYS
501-550501FISLFIYMVL511SLFIALITGA521YDTIKHPGGA531GAEESELQAY541IAQCQDSPTS
551-580551GKFRRGSGSA561CSLLCCCGRD571PSEEHSLLVN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 53 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.96
Deep-Palm: 0.94
|
|
| 64 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.92
|
|
| 166 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.72
|
|
| 192 | - | - | - |
Deep-Palm: 0.08
|
|
| 253 | - | - | - |
Deep-Palm: 0.24
|
|
| 284 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.32
|
|
| 309 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.91
|
|
| 316 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.93
|
|
| 386 | - | - | - |
Deep-Palm: 0.89
|
|
| 429 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.26
|
|
| 430 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.16
|
|
| 431 | - | - | - |
Deep-Palm: 0.18
|
|
| 440 | - | - | - |
Deep-Palm: 0.07
|
|
| 442 | - | - | - |
Deep-Palm: 0.14
|
|
| 463 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.41
|
|
| 544 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.95
|
|
| 561 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.95
|
|
| 565 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.96
|
| 566 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.96
|
| 567 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
Jurkat T cell
Specificity: 0.333
3/3 (100.0%)
3
PC3
Specificity: 0.333
3/3 (100.0%)
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.111
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 44 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 61 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 108 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 173 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 253 | C → C | 0.001887 | SNP | Silent | UCEC |
| 318 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 428 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 442 | C → C | 0.002545 | SNP | Silent | GBM |
| 486 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 491 | W → C | 0.002506 | SNP | Missense Mutation | COAD |
| 554 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |