Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9GZU1 MCOLN1; ML4; TRPML1; MSTP080 Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient … Homo sapiens (Human) 580 aa

Protein Details: Q9GZU1 (MCOLN1)

Protein Information
Accession Q9GZU1
Protein Names Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1)
Gene Symbol MCOLN1; ML4; TRPML1; MSTP080
Organism Homo sapiens (Human)
Length 580 aa
Isoforms No isoforms
Related PMIDs 26111759 31251020 32944167 37611173
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.825
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
33
LNCaP cells
Specificity: 0.825
33/46 (71.7%)
4
Jurkat T cells
Specificity: 0.100
4/25 (16.0%)
3
PC3 cells
Specificity: 0.075
3/4 (75.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MTAPAGPRGS11ETERLLTPNP21GYGTQAGPSP31APPTPPEEED41LRRRLKYFFM
51-10051SPCDKFRAKG61RKPCKLMLQV71VKILVVTVQL81ILFGLSNQLA91VTFREENTIA
101-150101FRHLFLLGYS111DGADDTFAAY121TREQLYQAIF131HAVDQYLALP141DVSLGRYAYV
151-200151RGGGDPWTNG161SGLALCQRYY171HRGHVDPAND181TFDIDPMVVT191DCIQVDPPER
201-250201PPPPPSDDLT211LLESSSSYKN221LTLKFHKLVN231VTIHFRLKTI241NLQSLINNEI
251-300251PDCYTFSVLI261TFDNKAHSGR271IPISLETQAH281IQECKHPSVF291QHGDNSFRLL
301-350301FDVVVILTCS311LSFLLCARSL321LRGFLLQNEF331VGFMWRQRGR341VISLWERLEF
351-400351VNGWYILLVT361SDVLTISGTI371MKIGIEAKNL381ASYDVCSILL391GTSTLLVWVG
401-450401VIRYLTFFHN411YNILIATLRV421ALPSVMRFCC431CVAVIYLGYC441FCGWIVLGPY
451-500451HVKFRSLSMV461SECLFSLING471DDMFVTFAAM481QAQQGRSSLV491WLFSQLYLYS
501-550501FISLFIYMVL511SLFIALITGA521YDTIKHPGGA531GAEESELQAY541IAQCQDSPTS
551-580551GKFRRGSGSA561CSLLCCCGRD571PSEEHSLLVN
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
53 Experimental Prediction (High) - 37611173
64 Prediction (High) - -
166 Prediction (Low) - -
309 Prediction (Low) - -
316 Prediction (Medium) - -
429 Prediction (High) - -
430 Prediction (Medium) - -
463 Prediction (High) - -
561 Prediction (High) - -
565 DBPTM SWISSPALM Prediction (Medium) - -
566 DBPTM SWISSPALM Prediction (Medium) - -
567 DBPTM SWISSPALM Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
44 R → C 0.001887 SNP Missense Mutation UCEC
61 R → C 0.001887 SNP Missense Mutation UCEC
108 G → C 0.002033 SNP Missense Mutation LUSC
173 G → C 0.001887 SNP Missense Mutation UCEC
253 C → C 0.001887 SNP Silent UCEC
318 R → C 0.002506 SNP Missense Mutation COAD
428 F → C 0.001887 SNP Missense Mutation UCEC
442 C → C 0.002545 SNP Silent GBM
486 R → C 0.005435 SNP Missense Mutation ESCA
491 W → C 0.002506 SNP Missense Mutation COAD
554 R → C 0.001887 SNP Missense Mutation UCEC