Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9GZY6 | LAT2 | Linker for activation of T-cells … | Homo sapiens (Human) | 243 aa |
Protein Details: Q9GZY6 (LAT2)
Protein Information
| Accession | Q9GZY6 |
|---|---|
| Protein Names | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) |
| Gene Symbol | LAT2 |
| Organism | Homo sapiens (Human) |
| Length | 243 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 31382980 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSSGTELLWP11GAALLVLLGV21AASLCVRCSR31PGAKRSEKIY41QQRSLREDQQ
51-10051SFTGSRTYSL61VGQAWPGPLA71DMAPTRKDKL81LQFYPSLEDP91ASSRYQNFSK
101-150101GSRHGSEEAY111IDPIAMEYYN121WGRFSKPPED131DDANSYENVL141ICKQKTTETG
151-200151AQQEGIGGLC161RGDLSLSLAL171KTGPTSGLCP181SASPEEDEES191EDYQNSASIH
201-243201QWRESRKVMG211QLQREASPGP221VGSPDEEDGE231PDYVNGEVAA241TEA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 25 | DBPTM | Linker for activation of T-cells family member 2 | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.99
|
| 28 | DBPTM | Linker for activation of T-cells family member 2 | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
| 142 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.65
|
|
| 160 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.98
|
|
| 179 | - | - | - |
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
CEM 174 cell
Specificity: 0.750
3/3 (100.0%)
1
U937 cell
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 30 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 30 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 30 | R → C | 0.015152 | SNP | Missense Mutation | KICH |