Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9H3N1 | TMX1 | Thioredoxin-related transmembrane protein 1 (Protein … | Homo sapiens (Human) | 280 aa |
Protein Details: Q9H3N1 (TMX1)
Protein Information
| Accession | Q9H3N1 |
|---|---|
| Protein Names | Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) |
| Gene Symbol | TMX1 |
| Organism | Homo sapiens (Human) |
| Length | 280 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 22496122 24357059 25914232 26111759 29575903 29733200 31251020 31382980 32651440 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPSGSLAVP11LAVLVLLLWG21APWTHGRRSN31VRVITDENWR41ELLEGDWMIE
51-10051FYAPWCPACQ61NLQPEWESFA71EWGEDLEVNI81AKVDVTEQPG91LSGRFIITAL
101-150101PTIYHCKDGE111FRRYQGPRTK121KDFINFISDK131EWKSIEPVSS141WFGPGSVLMS
151-200151SMSALFQLSM161WIRTCHNYFI171EDLGLPVWGS181YTVFALATLF191SGLLLGLCMI
201-250201FVADCLCPSK211RRRPQPYPYP221SKKLLSESAQ231PLKKVEEEQE241ADEEDVSEEE
251-280251AESKEGTNKD261FPQNAIRQRS271LGPSLATDKS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 56 | - | - | - |
Deep-Palm: 0.07
|
|
| 59 | - | - | - |
Deep-Palm: 0.04
|
|
| 106 | SWISSPALM DBPTM CYSMODDB | Thioredoxin |
HeLa
(29575903)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.71
Deep-Palm: 0.97
|
| 165 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.48
|
| 198 | - | - | - |
Deep-Palm: 0.85
|
|
| 205 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.95
|
| 207 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.276
8
Jurkat T cell
Specificity: 0.235
8/8 (100.0%)
4
LNCaP
Specificity: 0.118
4/4 (100.0%)
3
Primary T cell
Specificity: 0.088
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.088
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.059
2/2 (100.0%)
2
HeLa cell
Specificity: 0.059
2/2 (100.0%)
2
293T cell
Specificity: 0.059
2/2 (100.0%)
1
U937 cell
Specificity: 0.029
1/1 (100.0%)
1
EC cell
Specificity: 0.029
1/1 (100.0%)
1
CEM 174 cell
Specificity: 0.029
1/1 (100.0%)
1
heart
Specificity: 0.029
1/1 (100.0%)
1
HUVECs
Specificity: 0.029
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
Cerebral Cortex (Mass)
Specificity: 0.088
3/4 (75.0%)
2
LNCaP cells (Mass)
Specificity: 0.059
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 260 | D → _F261insQKCI | 0.002427 | INS | In Frame Ins | BLCA |
| 269 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |