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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9H3N1 TMX1; TMX; TXNDC; TXNDC1; PSEC0085; UNQ235/PRO268 Thioredoxin-related transmembrane protein 1 (Protein … Homo sapiens (Human) 280 aa

Protein Details: Q9H3N1 (TMX1)

Protein Information
Accession Q9H3N1
Protein Names Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
Gene Symbol TMX1; TMX; TXNDC; TXNDC1; PSEC0085; UNQ235/PRO268
Organism Homo sapiens (Human)
Length 280 aa
Isoforms No isoforms
Related PMIDs 19137006 19801377 21076176 22496122 24357059 25914232 26111759 29575903 29733200 31251020 31382980 32651440 32944167 33636221 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.440
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
44
LNCaP cells
Specificity: 0.440
44/46 (95.7%)
17
Jurkat T cells
Specificity: 0.170
17/25 (68.0%)
10
HAP1 cells
Specificity: 0.100
10/10 (100.0%)
10
293T cells
Specificity: 0.100
10/10 (100.0%)
4
PC3 cells
Specificity: 0.040
4/4 (100.0%)
4
T cells
Specificity: 0.040
4/4 (100.0%)
3
Cerebral cortex
Specificity: 0.030
3/4 (75.0%)
2
DU145 cells
Specificity: 0.020
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.020
2/2 (100.0%)
1
U937 cells
Specificity: 0.010
1/1 (100.0%)
1
HeLa cells
Specificity: 0.010
1/1 (100.0%)
1
CEMx174 cells
Specificity: 0.010
1/3 (33.3%)
1
Liver membrane
Specificity: 0.010
1/1 (100.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAPSGSLAVP11LAVLVLLLWG21APWTHGRRSN31VRVITDENWR41ELLEGDWMIE
51-10051FYAPWCPACQ61NLQPEWESFA71EWGEDLEVNI81AKVDVTEQPG91LSGRFIITAL
101-150101PTIYHCKDGE111FRRYQGPRTK121KDFINFISDK131EWKSIEPVSS141WFGPGSVLMS
151-200151SMSALFQLSM161WIRTCHNYFI171EDLGLPVWGS181YTVFALATLF191SGLLLGLCMI
201-250201FVADCLCPSK211RRRPQPYPYP221SKKLLSESAQ231PLKKVEEEQE241ADEEDVSEEE
251-280251AESKEGTNKD261FPQNAIRQRS271LGPSLATDKS
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
106 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Low) Thioredoxin 29575903
165 Experimental CYSMODDB SWISSPALM DBPTM - 29575903
205 DBPTM SWISSPALM Prediction (High) - -
207 DBPTM SWISSPALM Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
20 G → C 0.001887 SNP Missense Mutation UCEC
260 D → _F261insQKCI 0.002427 INS In Frame Ins BLCA
269 R → C 0.001887 SNP Missense Mutation UCEC