Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9H5Q4 | TFB2M; NS5ATP5 | Dimethyladenosine transferase 2, mitochondrial (EC … | Homo sapiens (Human) | 396 aa |
Protein Details: Q9H5Q4 (TFB2M)
Protein Information
| Accession | Q9H5Q4 |
|---|---|
| Protein Names | Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2) |
| Gene Symbol | TFB2M; NS5ATP5 |
| Organism | Homo sapiens (Human) |
| Length | 396 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 29733200 31251020 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.659
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
27
LNCaP cells
Specificity: 0.659
27/46 (58.7%)
6
Jurkat T cells
Specificity: 0.146
6/25 (24.0%)
4
HAP1 cells
Specificity: 0.098
4/10 (40.0%)
3
PC3 cells
Specificity: 0.073
3/4 (75.0%)
1
Endothelial cells
Specificity: 0.024
1/2 (50.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MWIPVVGLPR11RLRLSALAGA21GRFCILGSEA31ATRKHLPARN41HCGLSDSSPQ
51-10051LWPEPDFRNP61PRKASKASLD71FKRYVTDRRL81AETLAQIYLG91KPSRPPHLLL
101-150101ECNPGPGILT111QALLEAGAKV121VALESDKTFI131PHLESLGKNL141DGKLRVIHCD
151-200151FFKLDPRSGG161VIKPPAMSSR171GLFKNLGIEA181VPWTADIPLK191VVGMFPSRGE
201-250201KRALWKLAYD211LYSCTSIYKF221GRIEVNMFIG231EKEFQKLMAD241PGNPDLYHVL
251-300251SVIWQLACEI261KVLHMEPWSS271FDIYTRKGPL281ENPKRRELLD291QLQQKLYLIQ
301-350301MIPRQNLFTK311NLTPMNYNIF321FHLLKHCFGR331RSATVIDHLR341SLTPLDARDI
351-396351LMQIGKQEDE361KVVNMHPQDF371KTLFETIERS381KDCAYKWLYD391ETLEDR
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 24 | Prediction (High) | - | - |
| 42 | Prediction (Low) | - | - |
| 149 | Prediction (Medium) | - | - |
| 214 | Prediction (Medium) | - | - |
| 383 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 24 | C → Afs*3 | 0.002506 | DEL | Frame Shift Del | COAD |
| 129 | F → C | 0.002288 | SNP | Missense Mutation | STAD |
| 220 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 247 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 285 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 304 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 331 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 340 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |