Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9H5Q4 | TFB2M | Dimethyladenosine transferase 2, mitochondrial (EC … | Homo sapiens (Human) | 396 aa |
Protein Details: Q9H5Q4 (TFB2M)
Protein Information
| Accession | Q9H5Q4 |
|---|---|
| Protein Names | Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2) |
| Gene Symbol | TFB2M |
| Organism | Homo sapiens (Human) |
| Length | 396 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 29733200 31251020 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MWIPVVGLPR11RLRLSALAGA21GRFCILGSEA31ATRKHLPARN41HCGLSDSSPQ
51-10051LWPEPDFRNP61PRKASKASLD71FKRYVTDRRL81AETLAQIYLG91KPSRPPHLLL
101-150101ECNPGPGILT111QALLEAGAKV121VALESDKTFI131PHLESLGKNL141DGKLRVIHCD
151-200151FFKLDPRSGG161VIKPPAMSSR171GLFKNLGIEA181VPWTADIPLK191VVGMFPSRGE
201-250201KRALWKLAYD211LYSCTSIYKF221GRIEVNMFIG231EKEFQKLMAD241PGNPDLYHVL
251-300251SVIWQLACEI261KVLHMEPWSS271FDIYTRKGPL281ENPKRRELLD291QLQQKLYLIQ
301-350301MIPRQNLFTK311NLTPMNYNIF321FHLLKHCFGR331RSATVIDHLR341SLTPLDARDI
351-396351LMQIGKQEDE361KVVNMHPQDF371KTLFETIERS381KDCAYKWLYD391ETLEDR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 24 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 42 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.81
|
|
| 102 | - | - | - |
Deep-Palm: 0.98
|
|
| 149 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.98
|
|
| 214 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.83
|
|
| 258 | - | - | - |
Deep-Palm: 0.09
|
|
| 327 | - | - | - |
Deep-Palm: 0.52
|
|
| 383 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.49
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
4
Jurkat T cell
Specificity: 0.333
4/4 (100.0%)
3
LNCaP
Specificity: 0.250
3/3 (100.0%)
3
PC3
Specificity: 0.250
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.083
1/1 (100.0%)
1
HUVECs
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 24 | C → Afs*3 | 0.002506 | DEL | Frame Shift Del | COAD |
| 129 | F → C | 0.002288 | SNP | Missense Mutation | STAD |
| 220 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 247 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 285 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 304 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 331 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 340 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |