Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) 1894 aa

Protein Details: Q9HCM2 (PLXNA4)

Protein Information
AccessionQ9HCM2
Protein NamesPlexin-A4
Gene SymbolPLXNA4
OrganismHomo sapiens (Human)
Length1894 aa
IsoformsNo isoforms
Related PMIDs 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MKAMPWNWTC11LLSHLLMVGM21GSSTLLTRQP31APLSQKQRSF41VTFRGEPAEG
51-10051FNHLVVDERT61GHIYLGAVNR71IYKLSSDLKV81LVTHETGPDE91DNPKCYPPRI
101-150101VQTCNEPLTT111TNNVNKMLLI121DYKENRLIAC131GSLYQGICKL141LRLEDLFKLG
151-200151EPYHKKEHYL161SGVNESGSVF171GVIVSYSNLD181DKLFIATAVD191GKPEYFPTIS
201-250201SRKLTKNSEA211DGMFAYVFHD221EFVASMIKIP231SDTFTIIPDF241DIYYVYGFSS
251-300251GNFVYFLTLQ261PEMVSPPGST271TKEQVYTSKL281VRLCKEDTAF291NSYVEVPIGC
301-350301ERSGVEYRLL311QAAYLSKAGA321VLGRTLGVHP331DDDLLFTVFS341KGQKRKMKSL
351-400351DESALCIFIL361KQINDRIKER371LQSCYRGEGT381LDLAWLKVKD391IPCSSALLTI
401-450401DDNFCGLDMN411APLGVSDMVR421GIPVFTEDRD431RMTSVIAYVY441KNHSLAFVGT
451-500451KSGKLKKIRV461DGPRGNALQY471ETVQVVDPGP481VLRDMAFSKD491HEQLYIMSER
501-550501QLTRVPVESC511GQYQSCGECL521GSGDPHCGWC531VLHNTCTRKE541RCERSKEPRR
551-600551FASEMKQCVR561LTVHPNNISV571SQYNVLLVLE581TYNVPELSAG591VNCTFEDLSE
601-650601MDGLVVGNQI611QCYSPAAKEV621PRIITENGDH631HVVQLQLKSK641ETGMTFASTS
651-700651FVFYNCSVHN661SCLSCVESPY671RCHWCKYRHV681CTHDPKTCSF691QEGRVKLPED
701-750701CPQLLRVDKI711LVPVEVIKPI721TLKAKNLPQP731QSGQRGYECI741LNIQGSEQRV
751-800751PALRFNSSSV761QCQNTSYSYE771GMEINNLPVE781LTVVWNGHFN791IDNPAQNKVH
801-850801LYKCGAMRES811CGLCLKADPD821FACGWCQGPG831QCTLRQHCPA841QESQWLELSG
851-900851AKSKCTNPRI861TEIIPVTGPR871EGGTKVTIRG881ENLGLEFRDI891ASHVKVAGVE
901-950901CSPLVDGYIP911AEQIVCEMGE921AKPSQHAGFV931EICVAVCRPE941FMARSSQLYY
951-1000951FMTLTLSDLK961PSRGPMSGGT971QVTITGTNLN981AGSNVVVMFG991KQPCLFHRRS
1001-10501001PSYIVCNTTS1011SDEVLEMKVS1021VQVDRAKIHQ1031DLVFQYVEDP1041TIVRIEPEWS
1051-11001051IVSGNTPIAV1061WGTHLDLIQN1071PQIRAKHGGK1081EHINICEVLN1091ATEMTCQAPA
1101-11501101LALGPDHQSD1111LTERPEEFGF1121ILDNVQSLLI1131LNKTNFTYYP1141NPVFEAFGPS
1151-12001151GILELKPGTP1161IILKGKNLIP1171PVAGGNVKLN1181YTVLVGEKPC1191TVTVSDVQLL
1201-12501201CESPNLIGRH1211KVMARVGGME1221YSPGMVYIAP1231DSPLSLPAIV1241SIAVAGGLLI
1251-13001251IFIVAVLIAY1261KRKSRESDLT1271LKRLQMQMDN1281LESRVALECK1291EAFAELQTDI
1301-13501301HELTSDLDGA1311GIPFLDYRTY1321TMRVLFPGIE1331DHPVLRDLEV1341PGYRQERVEK
1351-14001351GLKLFAQLIN1361NKVFLLSFIR1371TLESQRSFSM1381RDRGNVASLI1391MTVLQSKLEY
1401-14501401ATDVLKQLLA1411DLIDKNLESK1421NHPKLLLRRT1431ESVAEKMLTN1441WFTFLLYKFL
1451-15001451KECAGEPLFS1461LFCAIKQQME1471KGPIDAITGE1481ARYSLSEDKL1491IRQQIDYKTL
1501-15501501VLSCVSPDNA1511NSPEVPVKIL1521NCDTITQVKE1531KILDAIFKNV1541PCSHRPKAAD
1551-16001551MDLEWRQGSG1561ARMILQDEDI1571TTKIENDWKR1581LNTLAHYQVP1591DGSVVALVSK
1601-16501601QVTAYNAVNN1611STVSRTSASK1621YENMIRYTGS1631PDSLRSRTPM1641ITPDLESGVK
1651-17001651MWHLVKNHEH1661GDQKEGDRGS1671KMVSEIYLTR1681LLATKGTLQK1691FVDDLFETIF
1701-17501701STAHRGSALP1711LAIKYMFDFL1721DEQADKHGIH1731DPHVRHTWKS1741NCLPLRFWVN
1751-18001751MIKNPQFVFD1761IHKNSITDAC1771LSVVAQTFMD1781SCSTSEHRLG1791KDSPSNKLLY
1801-18501801AKDIPSYKNW1811VERYYSDIGK1821MPAISDQDMN1831AYLAEQSRMH1841MNEFNTMSAL
1851-18941851SEIFSYVGKY1861SEEILGPLDH1871DDQCGKQKLA1881YKLEQVITLM1891SLDS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
10 - - -
Deep-Palm: 0.03
95 - - -
Deep-Palm: 0.20
104 - - -
Deep-Palm: 0.09
130 - -
cerebral cortex (36430497)
GPS-Palm: 0.78
Deep-Palm: 0.90
138 - -
cerebral cortex (36430497)
GPS-Palm: 0.79
Deep-Palm: 0.92
284 - - -
GPS-Palm: 0.67
Deep-Palm: 0.91
300 - - -
GPS-Palm: 0.66
Deep-Palm: 0.95
356 - - -
GPS-Palm: 0.93
Deep-Palm: 0.95
374 - - -
GPS-Palm: 0.72
Deep-Palm: 0.97
393 - - -
GPS-Palm: 0.86
Deep-Palm: 0.93
405 - - -
Deep-Palm: 0.49
510 - - -
Deep-Palm: 0.43
516 - - -
Deep-Palm: 0.05
519 - - -
Deep-Palm: 0.04
527 - - -
Deep-Palm: 0.06
530 - - -
Deep-Palm: 0.12
536 - - -
Deep-Palm: 0.11
542 - - -
Deep-Palm: 0.24
558 - - -
GPS-Palm: 0.79
Deep-Palm: 0.77
593 - - -
Deep-Palm: 0.78
612 - - -
GPS-Palm: 0.70
Deep-Palm: 0.84
656 - - -
Deep-Palm: 0.03
662 - - -
Deep-Palm: 0.01
665 - - -
Deep-Palm: 0.01
672 - - -
Deep-Palm: 0.02
675 - - -
Deep-Palm: 0.02
681 - - -
Deep-Palm: 0.03
688 - - -
Deep-Palm: 0.03
701 - - -
GPS-Palm: 0.85
Deep-Palm: 0.82
739 - - -
GPS-Palm: 0.66
Deep-Palm: 0.92
762 - - -
Deep-Palm: 0.56
804 - - -
Deep-Palm: 0.44
811 SWISSPALM DBPTM CYSMODDB Plexin repeat - -
GPS-Palm: 0.80
Deep-Palm: 0.20
814 SWISSPALM DBPTM CYSMODDB Plexin repeat - -
Deep-Palm: 0.21
823 - - -
Deep-Palm: 0.35
826 - - -
Deep-Palm: 0.39
832 - - -
Deep-Palm: 0.08
838 - - -
Deep-Palm: 0.49
855 - - -
GPS-Palm: 0.81
Deep-Palm: 0.81
901 - - -
Deep-Palm: 0.87
916 - - -
Deep-Palm: 0.65
933 - - -
Deep-Palm: 0.68
937 - - -
Deep-Palm: 0.27
994 - - -
GPS-Palm: 0.74
Deep-Palm: 0.20
1006 - - -
GPS-Palm: 0.70
Deep-Palm: 0.50
1086 - - -
Deep-Palm: 0.53
1096 - - -
Deep-Palm: 0.38
1190 - - -
Deep-Palm: 0.83
1201 - - -
GPS-Palm: 0.77
Deep-Palm: 0.90
1289 - - -
Deep-Palm: 0.69
1453 - - -
GPS-Palm: 0.71
Deep-Palm: 0.49
1463 - - -
GPS-Palm: 0.91
Deep-Palm: 0.77
1504 - - -
GPS-Palm: 0.77
Deep-Palm: 0.88
1522 - - -
GPS-Palm: 0.77
Deep-Palm: 0.79
1542 - - -
GPS-Palm: 0.81
Deep-Palm: 0.93
1742 - - -
GPS-Palm: 0.80
Deep-Palm: 0.16
1770 - - -
Deep-Palm: 0.11
1782 - - -
GPS-Palm: 0.68
Deep-Palm: 0.65
1874 - - -
Deep-Palm: 0.87
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 1.000
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
300 C → Y 0.001887 SNP Missense Mutation UCEC
302 R → C 0.002545 SNP Missense Mutation GBM
308 R → C 0.003774 SNP Missense Mutation UCEC
516 C → C 0.001887 SNP Silent UCEC
527 C → C 0.001969 SNP Silent HNSC
824 G → C 0.001764 SNP Missense Mutation LUAD
835 R → C 0.019608 SNP Missense Mutation CHOL
835 R → C 0.001887 SNP Missense Mutation UCEC
855 C → Y 0.001969 SNP Missense Mutation HNSC
888 R → C 0.002141 SNP Missense Mutation SKCM
888 R → C 0.001887 SNP Missense Mutation UCEC
901 C → Y 0.003460 SNP Missense Mutation CESC
933 C → Y 0.001764 SNP Missense Mutation LUAD
966 M → Cfs*7 0.002288 DEL Frame Shift Del STAD
966 M → Cfs*7 0.002506 DEL Frame Shift Del COAD
994 C → S 0.002747 SNP Missense Mutation LIHC
1003 Y → C 0.002545 SNP Missense Mutation GBM
1086 C → Y 0.001887 SNP Missense Mutation UCEC
1201 C → C 0.001887 SNP Silent UCEC
1227 Y → C 0.002288 SNP Missense Mutation STAD
1262 R → C 0.003774 SNP Missense Mutation UCEC
1320 Y → C 0.001969 SNP Missense Mutation LGG
1325 L → Cfs*29 0.003559 INS Frame Shift Ins KIRP
1342 G → C 0.002288 SNP Missense Mutation STAD
1347 R → C 0.005618 SNP Missense Mutation PAAD
1381 R → C 0.002288 SNP Missense Mutation STAD
1381 R → C 0.001887 SNP Missense Mutation UCEC
1463 C → G 0.002747 SNP Missense Mutation LIHC
1559 S → C 0.002288 SNP Missense Mutation STAD
1619 S → C 0.002545 SNP Missense Mutation GBM
1742 C → C 0.002033 SNP Splice Region LUSC
1770 C → G 0.002033 SNP Missense Mutation LUSC
356* C → ? 0.001764 SNP Nonsense Mutation LUAD
1201* C → ? 0.002033 SNP Nonsense Mutation LUSC
688* C → ? 0.001887 SNP Nonsense Mutation UCEC