Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9NRX5 | SERINC1 | Serine incorporator 1 (Tumor differentially … | Homo sapiens (Human) | 453 aa |
Protein Details: Q9NRX5 (SERINC1)
Protein Information
| Accession | Q9NRX5 |
|---|---|
| Protein Names | Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) |
| Gene Symbol | SERINC1 |
| Organism | Homo sapiens (Human) |
| Length | 453 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGSVLGLCSM11ASWIPCLCGS21APCLLCRCCP31SGNNSTVTRL41IYALFLLVGV
51-10051CVACVMLIPG61MEEQLNKIPG71FCENEKGVVP81CNILVGYKAV91YRLCFGLAMF
101-150101YLLLSLLMIK111VKSSSDPRAA121VHNGFWFFKF131AAAIAIIIGA141FFIPEGTFTT
151-200151VWFYVGMAGA161FCFILIQLVL171LIDFAHSWNE181SWVEKMEEGN191SRCWYAALLS
201-250201ATALNYLLSL211VAIVLFFVYY221THPASCSENK231AFISVNMLLC241VGASVMSILP
251-300251KIQESQPRSG261LLQSSVITVY271TMYLTWSAMT281NEPETNCNPS291LLSIIGYNTT
301-350301STVPKEGQSV311QWWHAQGIIG321LILFLLCVFY331SSIRTSNNSQ341VNKLTLTSDE
351-400351STLIEDGGAR361SDGSLEDGDD371VHRAVDNERD381GVTYSYSFFH391FMLFLASLYI
401-450401MMTLTNWYRY411EPSREMKSQW421TAVWVKISSS431WIGIVLYVWT441LVAPLVLTNR
451-453451DFD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.02
|
|
| 16 | - | - | - |
Deep-Palm: 0.36
|
|
| 18 | - | - | - |
Deep-Palm: 0.46
|
|
| 23 | Serine incorporator/TMS membrane protein | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.18
|
|
| 26 | Serine incorporator/TMS membrane protein | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.49
|
|
| 28 | Serine incorporator/TMS membrane protein | - | - |
Deep-Palm: 0.32
|
|
| 29 | Serine incorporator/TMS membrane protein | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.60
|
|
| 51 | - | - | - |
Deep-Palm: 0.84
|
|
| 54 | - | - | - |
Deep-Palm: 0.92
|
|
| 72 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.77
|
|
| 81 | SWISSPALM DBPTM CYSMODDB | Serine incorporator (Serinc) | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
| 94 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.89
|
|
| 162 | - | - | - |
Deep-Palm: 0.09
|
|
| 193 | - | - | - |
Deep-Palm: 0.84
|
|
| 226 | - | - | - |
Deep-Palm: 0.14
|
|
| 240 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.64
|
|
| 287 | - | - | - |
Deep-Palm: 0.15
|
|
| 327 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.42
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.222
4
Primary T cell
Specificity: 0.174
4/4 (100.0%)
4
PC3
Specificity: 0.174
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.174
4/4 (100.0%)
3
LNCaP
Specificity: 0.130
3/3 (100.0%)
2
Jurkat T cell
Specificity: 0.087
2/2 (100.0%)
1
HUVECs
Specificity: 0.043
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.174
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.043
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 26 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 152 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 217 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 220 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 385 | S → C | 0.002545 | SNP | Missense Mutation | GBM |
| 408 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 410 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 424 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 431 | W → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 450 | R → C | 0.007299 | SNP | Missense Mutation | READ |