Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9NUB1-2 | ACSS1 | Acetyl-coenzyme A synthetase 2-like, mitochondrial … | Homo sapiens (Human) | 687 aa |
Protein Details: Q9NUB1-2 (ACSS1)
Protein Information
| Accession | Q9NUB1-2 |
|---|---|
| Protein Names | Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17) |
| Gene Symbol | ACSS1 |
| Organism | Homo sapiens (Human) |
| Length | 687 aa |
| Isoforms | |
| Related PMIDs | 33636221 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAARTLGRGV11GRLLGSLRGL21SGQPARPPCG31VSAPRRAASG41PSGSAPAVAA
51-10051AAAQPGSYPA61LSAQAAREPA71AFWGPLARDT81LVWDTPYHTV91WDCDFSTGKI
101-150101GWFLGGQLNV111SVNCLDQHVR121KSPESVALIW131ERDEPGTEVR141ITYRELLETT
151-200151CRLANTLKRH161GVHRGDRVAI171YMPVSPLAVA181AMLACARIGA191VHTVIFAGFS
201-250201AESLAGRIND211AKCKVVITFN221QGLRGGRVVE231LKKIVDEAVK241HCPTVQHVLV
251-300251AHRTDNKVHM261GDLDVPLEQE271MAKEDPVCAP281ESMGSEDMLF291MLYTSGSTGM
301-350301PKGIVHTQAG311YLLYAALTHK321LVFDHQPGDI331FGCVADIGWI341TGHSYVVYGP
351-400351LCNGATSVLF361ESTPVYPNAG371RYWETVERLK381INQFYGAPTA391VRLLLKYGDA
401-450401WVKKYDRSSL411RTLGSVGEPI421NCEAWEWLHR431VVGDSRCTLV441DTWWQTGGIC
451-500451IAPRPSEEGA461EILPAMAMRP471FFGIVPVLMD481EKGSVVEGSN491VSGALCISQA
501-550501WPGMARTIYG511DHQRFVDAYF521KAYPGYYFTG531DGAYRTEGGY541YQITGRMDDV
551-600551INISGHRLGT561AEIEDAIADH571PAVPESAVIG581YPHDIKGEAA591FAFIVVKDSA
601-650601GDSDVVVQEL611KSMVATKIAK621YAVPDEILVV631KRLPKTRSGK641VMRRLLRKII
651-687651TSEAQELGDT661TTLEDPSIIA671EILSVYQKCK681DKQAAAK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 29 | - | - | - |
Deep-Palm: 0.98
|
|
| 93 | - | - | - |
Deep-Palm: 0.17
|
|
| 114 | - | - | - |
Deep-Palm: 0.92
|
|
| 151 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.96
|
|
| 185 | - | - | - |
Deep-Palm: 0.84
|
|
| 213 | - | - | - |
Deep-Palm: 0.96
|
|
| 242 | - | - | - |
Deep-Palm: 0.92
|
|
| 278 | - | - | - |
Deep-Palm: 0.61
|
|
| 333 | - | - | - |
Deep-Palm: 0.08
|
|
| 352 | - | - | - |
Deep-Palm: 0.29
|
|
| 422 | - | - | - |
Deep-Palm: 0.90
|
|
| 437 | - | - | - |
Deep-Palm: 0.19
|
|
| 452 | - | - | - |
Deep-Palm: 0.87
|
|
| 498 | - | - | - |
Deep-Palm: 0.91
|
|
| 681 | - | - | - |
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
cerebral cortex
Specificity: 0.750
3/3 (100.0%)
1
heart
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 164 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 213 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 373 | W → C | 0.002545 | SNP | Missense Mutation | GBM |
| 407 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 409 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 422 | C → Y | 0.003460 | SNP | Missense Mutation | CESC |
| 437 | C → S | 0.002294 | SNP | Missense Mutation | OV |