Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9NWQ8 | PAG1 | Phosphoprotein associated with glycosphingolipid-enriched microdomains … | Homo sapiens (Human) | 432 aa |
Protein Details: Q9NWQ8 (PAG1)
Protein Information
| Accession | Q9NWQ8 |
|---|---|
| Protein Names | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) |
| Gene Symbol | PAG1 |
| Organism | Homo sapiens (Human) |
| Length | 432 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 26111759 31251020 31382980 32651440 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGPAGSLLGS11GQMQITLWGS21LAAVAIFFVI31TFLIFLCSSC41DREKKPRQHS
51-10051GDHENLMNVP61SDKEMFSRSV71TSLATDAPAS81SEQNGALTNG91DILSEDSTLT
101-150101CMQHYEEVQT111SASDLLDSQD121STGKPKCHQS131RELPRIPPES141AVDTMLTARS
151-200151VDGDQGLGME161GPYEVLKDSS171SQENMVEDCL181YETVKEIKEV191AAAAHLEKGH
201-250201SGKAKSTSAS211KELPGPQTEG221KAEFAEYASV231DRNKKCRQSV241NVESILGNSC
251-300251DPEEEAPPPV261PVKLLDENEN271LQEKEGGEAE281ESATDTTSET291NKRFSSLSYK
301-350301SREEDPTLTE311EEISAMYSSV321NKPGQLVNKS331GQSLTVPEST341YTSIQGDPQR
351-400351SPSSCNDLYA361TVKDFEKTPN371STLPPAGRPS381EEPEPDYEAI391QTLNREEEKA
401-432401TLGTNGHHGL411VPKENDYESI421SDLQQGRDIT431RL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 37 | DBPTM | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Phosphoprotein associated with glycosphingolipid-enriched | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.78
|
| 40 | DBPTM | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Phosphoprotein associated with glycosphingolipid-enriched | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.38
|
| 101 | - | - | - |
Deep-Palm: 0.66
|
|
| 127 | - | - | - |
Deep-Palm: 0.86
|
|
| 179 | - | - | - |
Deep-Palm: 0.90
|
|
| 236 | - | - | - |
Deep-Palm: 0.55
|
|
| 250 | - | - | - |
Deep-Palm: 0.85
|
|
| 355 | - | - | - |
Deep-Palm: 0.69
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
6
Jurkat T cell
Specificity: 0.429
6/6 (100.0%)
3
CEM 174 cell
Specificity: 0.214
3/3 (100.0%)
2
LNCaP
Specificity: 0.143
2/2 (100.0%)
2
Primary T cell
Specificity: 0.143
2/2 (100.0%)
1
U937 cell
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 179 | C → C | 0.001887 | SNP | Silent | UCEC |
| 237 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 341 | Y → C | 0.002294 | SNP | Missense Mutation | OV |