Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9NZ45 | CISD1 | CDGSH iron-sulfur domain-containing protein 1 … | Homo sapiens (Human) | 108 aa |
Protein Details: Q9NZ45 (CISD1)
Protein Information
| Accession | Q9NZ45 |
|---|---|
| Protein Names | CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET) |
| Gene Symbol | CISD1 |
| Organism | Homo sapiens (Human) |
| Length | 108 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 31251020 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSLTSSSSVR11VEWIAAVTIA21AGTAAIGYLA31YKRFYVKDHR41NKAMINLHIQ
51-10051KDNPKIVHAF61DMEDLGDKAV71YCRCWRSKKF81PFCDGAHTKH91NEETGDNVGP
101-108101LIIKKKET
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 72 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.24
|
|
| 74 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.24
|
|
| 83 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.88
Deep-Palm: 0.23
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
cerebral cortex
Specificity: 0.286
4/4 (100.0%)
2
LNCaP
Specificity: 0.143
2/2 (100.0%)
2
PC3
Specificity: 0.143
2/2 (100.0%)
1
heart
Specificity: 0.071
1/1 (100.0%)
1
HUVECs
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.286
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 73 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |