Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9NZV1 | CRIM1 | Cysteine-rich motor neuron 1 protein … | Homo sapiens (Human) | 1036 aa |
Protein Details: Q9NZV1 (CRIM1)
Protein Information
| Accession | Q9NZV1 |
|---|---|
| Protein Names | Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] |
| Gene Symbol | CRIM1 |
| Organism | Homo sapiens (Human) |
| Length | 1036 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MYLVAGDRGL11AGCGHLLVSL21LGLLLLLARS31GTRALVCLPC41DESKCEEPRN
51-10051CPGSIVQGVC61GCCYTCASQR71NESCGGTFGI81YGTCDRGLRC91VIRPPLNGDS
101-150101LTEYEAGVCE111DENWTDDQLL121GFKPCNENLI131AGCNIINGKC141ECNTIRTCSN
151-200151PFEFPSQDMC161LSALKRIEEE171KPDCSKARCE181VQFSPRCPED191SVLIEGYAPP
201-250201GECCPLPSRC211VCNPAGCLRK221VCQPGNLNIL231VSKASGKPGE241CCDLYECKPV
251-300251FGVDCRTVEC261PPVQQTACPP271DSYETQVRLT281ADGCCTLPTR291CECLSGLCGF
301-350301PVCEVGSTPR311IVSRGDGTPG321KCCDVFECVN331DTKPACVFNN341VEYYDGDMFR
351-400351MDNCRFCRCQ361GGVAICFTAQ371CGEINCERYY381VPEGECCPVC391EDPVYPFNNP
401-450401AGCYANGLIL411AHGDRWREDD421CTFCQCVNGE431RHCVATVCGQ441TCTNPVKVPG
451-500451ECCPVCEEPT461IITVDPPACG471ELSNCTLTGK481DCINGFKRDH491NGCRTCQCIN
501-550501TEELCSERKQ511GCTLNCPFGF521LTDAQNCEIC531ECRPRPKKCR541PIICDKYCPL
551-600551GLLKNKHGCD561ICRCKKCPEL571SCSKICPLGF581QQDSHGCLIC591KCREASASAG
601-650601PPILSGTCLT611VDGHHHKNEE621SWHDGCRECY631CLNGREMCAL641ITCPVPACGN
651-700651PTIHPGQCCP661SCADDFVVQK671PELSTPSICH681APGGEYFVEG691ETWNIDSCTQ
701-750701CTCHSGRVLC711ETEVCPPLLC721QNPSRTQDSC731CPQCTDQPFR741PSLSRNNSVP
751-800751NYCKNDEGDI761FLAAESWKPD771VCTSCICIDS781VISCFSESCP791SVSCERPVLR
801-850801KGQCCPYCIE811DTIPKKVVCH821FSGKAYADEE831RWDLDSCTHC841YCLQGQTLCS
851-900851TVSCPPLPCV861EPINVEGSCC871PMCPEMYVPE881PTNIPIEKTN891HRGEVDLEVP
901-950901LWPTPSENDI911VHLPRDMGHL921QVDYRDNRLH931PSEDSSLDSI941ASVVVPIIIC
951-1000951LSIIIAFLFI961NQKKQWIPLL971CWYRTPTKPS981SLNNQLVSVD991CKKGTRVQVD
1001-10361001SSQRMLRIAE1011PDARFSGFYS1021MQKQNHLQAD1031NFYQTV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.98
|
|
| 37 | Insulin-like growth factor-binding protein, IGFBP | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 40 | Insulin-like growth factor-binding protein, IGFBP | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.96
|
|
| 45 | Insulin-like growth factor-binding protein, IGFBP Growth factor receptor cysteine-rich domain superfamily | - | - |
Deep-Palm: 0.43
|
|
| 51 | Insulin-like growth factor-binding protein, IGFBP Growth factor receptor cysteine-rich domain superfamily | - | - |
Deep-Palm: 0.03
|
|
| 60 | - | - | - |
Deep-Palm: 0.04
|
|
| 62 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.04
|
|
| 63 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.03
|
|
| 66 | - | - | - |
Deep-Palm: 0.04
|
|
| 74 | - | - | - |
Deep-Palm: 0.07
|
|
| 84 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.49
|
|
| 90 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.96
|
|
| 109 | - | - | - |
Deep-Palm: 0.53
|
|
| 125 | - | - | - |
Deep-Palm: 0.05
|
|
| 133 | - | - | - |
Deep-Palm: 0.06
|
|
| 140 | - | - | - |
Deep-Palm: 0.02
|
|
| 142 | - | - | - |
Deep-Palm: 0.02
|
|
| 148 | - | - | - |
Deep-Palm: 0.02
|
|
| 160 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.67
|
|
| 174 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.85
|
|
| 179 | - | - | - |
Deep-Palm: 0.84
|
|
| 187 | - | - | - |
Deep-Palm: 0.81
|
|
| 203 | - | - | - |
Deep-Palm: 0.51
|
|
| 204 | - | - | - |
Deep-Palm: 0.52
|
|
| 210 | - | - | - |
Deep-Palm: 0.31
|
|
| 212 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.26
|
|
| 217 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.46
|
|
| 222 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.78
|
|
| 241 | - | - | - |
Deep-Palm: 0.31
|
|
| 242 | - | - | - |
Deep-Palm: 0.28
|
|
| 247 | - | - | - |
Deep-Palm: 0.12
|
|
| 255 | - | - | - |
Deep-Palm: 0.03
|
|
| 260 | - | - | - |
Deep-Palm: 0.04
|
|
| 268 | - | - | - |
Deep-Palm: 0.40
|
|
| 284 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.79
|
|
| 285 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 291 | - | - | - |
Deep-Palm: 0.66
|
|
| 293 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.56
|
|
| 298 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.57
|
|
| 303 | - | - |
Jurkat T
(32651440)
|
GPS-Palm: 0.65
Deep-Palm: 0.81
|
|
| 322 | - | - | - |
Deep-Palm: 0.08
|
|
| 323 | - | - | - |
Deep-Palm: 0.07
|
|
| 328 | - | - | - |
Deep-Palm: 0.03
|
|
| 336 | - | - | - |
Deep-Palm: 0.01
|
|
| 354 | - | - | - |
Deep-Palm: 0.02
|
|
| 357 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.02
|
|
| 359 | - | - | - |
Deep-Palm: 0.02
|
|
| 366 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.02
|
|
| 371 | - | - | - |
Deep-Palm: 0.02
|
|
| 376 | - | - | - |
Deep-Palm: 0.03
|
|
| 386 | - | - | - |
Deep-Palm: 0.03
|
|
| 387 | - | - | - |
Deep-Palm: 0.03
|
|
| 390 | - | - | - |
Deep-Palm: 0.03
|
|
| 403 | - | - | - |
Deep-Palm: 0.19
|
|
| 421 | - | - | - |
Deep-Palm: 0.03
|
|
| 424 | - | - | - |
Deep-Palm: 0.02
|
|
| 426 | - | - | - |
Deep-Palm: 0.02
|
|
| 433 | - | - | - |
Deep-Palm: 0.02
|
|
| 438 | - | - | - |
Deep-Palm: 0.02
|
|
| 442 | - | - | - |
Deep-Palm: 0.04
|
|
| 452 | - | - | - |
Deep-Palm: 0.07
|
|
| 453 | - | - | - |
Deep-Palm: 0.07
|
|
| 456 | - | - | - |
Deep-Palm: 0.10
|
|
| 469 | - | - | - |
Deep-Palm: 0.16
|
|
| 475 | - | - | - |
Deep-Palm: 0.41
|
|
| 482 | - | - | - |
Deep-Palm: 0.05
|
|
| 493 | - | - | - |
Deep-Palm: 0.03
|
|
| 496 | - | - | - |
Deep-Palm: 0.04
|
|
| 498 | - | - | - |
Deep-Palm: 0.05
|
|
| 505 | - | - | - |
Deep-Palm: 0.02
|
|
| 512 | - | - | - |
Deep-Palm: 0.08
|
|
| 516 | - | - | - |
Deep-Palm: 0.10
|
|
| 527 | - | - | - |
Deep-Palm: 0.04
|
|
| 530 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.04
|
|
| 532 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.04
|
|
| 539 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.10
|
|
| 544 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.14
|
|
| 548 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.17
|
|
| 559 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.08
|
|
| 562 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.07
|
|
| 564 | - | - | - |
Deep-Palm: 0.19
|
|
| 567 | - | - | - |
Deep-Palm: 0.08
|
|
| 572 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.03
|
|
| 576 | - | - | - |
Deep-Palm: 0.08
|
|
| 587 | - | - | - |
Deep-Palm: 0.21
|
|
| 590 | - | - | - |
Deep-Palm: 0.35
|
|
| 592 | - | - | - |
Deep-Palm: 0.61
|
|
| 608 | - | - | - |
Deep-Palm: 0.80
|
|
| 626 | - | - | - |
Deep-Palm: 0.02
|
|
| 629 | - | - | - |
Deep-Palm: 0.01
|
|
| 631 | - | - | - |
Deep-Palm: 0.02
|
|
| 638 | - | - | - |
Deep-Palm: 0.03
|
|
| 643 | - | - | - |
Deep-Palm: 0.03
|
|
| 648 | - | - | - |
Deep-Palm: 0.04
|
|
| 658 | - | - | - |
Deep-Palm: 0.08
|
|
| 659 | - | - | - |
Deep-Palm: 0.10
|
|
| 662 | - | - | - |
Deep-Palm: 0.08
|
|
| 679 | - | - | - |
Deep-Palm: 0.38
|
|
| 698 | - | - | - |
Deep-Palm: 0.03
|
|
| 701 | - | - | - |
Deep-Palm: 0.02
|
|
| 703 | - | - | - |
Deep-Palm: 0.02
|
|
| 710 | - | - | - |
Deep-Palm: 0.03
|
|
| 715 | - | - | - |
Deep-Palm: 0.08
|
|
| 720 | - | - | - |
Deep-Palm: 0.14
|
|
| 730 | - | - | - |
Deep-Palm: 0.12
|
|
| 731 | - | - | - |
Deep-Palm: 0.14
|
|
| 734 | - | - | - |
Deep-Palm: 0.11
|
|
| 753 | - | - | - |
Deep-Palm: 0.45
|
|
| 772 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.07
|
|
| 775 | - | - | - |
Deep-Palm: 0.04
|
|
| 777 | - | - | - |
Deep-Palm: 0.04
|
|
| 784 | - | - | - |
Deep-Palm: 0.03
|
|
| 789 | - | - | - |
Deep-Palm: 0.13
|
|
| 794 | - | - | - |
Deep-Palm: 0.08
|
|
| 804 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.20
|
|
| 805 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.15
|
|
| 808 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.16
|
|
| 819 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.14
|
|
| 837 | - | - | - |
Deep-Palm: 0.06
|
|
| 840 | - | - | - |
Deep-Palm: 0.03
|
|
| 842 | - | - | - |
Deep-Palm: 0.03
|
|
| 849 | - | - | - |
Deep-Palm: 0.02
|
|
| 854 | - | - | - |
Deep-Palm: 0.03
|
|
| 859 | - | - | - |
Deep-Palm: 0.04
|
|
| 869 | - | - | - |
Deep-Palm: 0.05
|
|
| 870 | - | - | - |
Deep-Palm: 0.04
|
|
| 873 | - | - | - |
Deep-Palm: 0.04
|
|
| 950 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.70
|
|
| 971 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.86
Deep-Palm: 0.44
|
|
| 991 | - | - | - |
Deep-Palm: 0.81
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HUVECs
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 37 | C → G | 0.010870 | SNP | Missense Mutation | ACC |
| 45 | C → C | 0.002033 | SNP | Silent | LUSC |
| 60 | C → C | 0.002427 | SNP | Silent | BLCA |
| 84 | C → S | 0.002427 | SNP | Missense Mutation | BLCA |
| 88 | L → Cfs*48 | 0.003774 | DEL | Frame Shift Del | UCEC |
| 109 | C → C | 0.001887 | SNP | Silent | UCEC |
| 174 | C → Lfs*7 | 0.001764 | INS | Frame Shift Ins | LUAD |
| 179 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 210 | C → C | 0.001887 | SNP | Silent | UCEC |
| 219 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 291 | C → C | 0.002506 | SNP | Silent | COAD |
| 313 | S → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 314 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 323 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 336 | C → C | 0.002506 | SNP | Silent | COAD |
| 354 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 373 | E → _I374insAAQCGE | 0.012195 | INS | In Frame Ins | MESO |
| 376 | C → C | 0.005618 | SNP | Silent | PAAD |
| 424 | C → C | 0.002294 | SNP | Silent | OV |
| 433 | C → C | 0.002506 | SNP | Silent | COAD |
| 433 | C → C | 0.001887 | SNP | Silent | UCEC |
| 481 | D → _C482del | 0.002033 | DEL | In Frame Del | LUSC |
| 482 | C → C | 0.001887 | SNP | Silent | UCEC |
| 508 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 532 | C → F | 0.001014 | SNP | Missense Mutation | BRCA |
| 544 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 548 | C → F | 0.002141 | SNP | Missense Mutation | SKCM |
| 563 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 629 | C → C | 0.010870 | SNP | Silent | ACC |
| 669 | Q → Cfs*114 | 0.004219 | INS | Frame Shift Ins | SARC |
| 701 | C → C | 0.002294 | SNP | Silent | OV |
| 794 | C → Lfs*6 | 0.002288 | DEL | Frame Shift Del | STAD |
| 837 | C → C | 0.001887 | SNP | Silent | UCEC |
| 548* | C → ? | 0.001764 | SNP | Nonsense Mutation | LUAD |
| 336* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |