Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9P258 | RCC2 | Protein RCC2 (RCC1-like protein TD-60) … | Homo sapiens (Human) | 522 aa |
Protein Details: Q9P258 (RCC2)
Protein Information
| Accession | Q9P258 |
|---|---|
| Protein Names | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) |
| Gene Symbol | RCC2 |
| Organism | Homo sapiens (Human) |
| Length | 522 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 29733200 31251020 31382980 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPRKKAAAAA11WEEPSSGNGT21ARAGPRKRGG31PAGRKRERPE41RCSSSSGGGS
51-10051SGDEDGLELD61GAPGGGKRAA71RPATAGKAGG81AAVVITEPEH91TKERVKLEGS
101-150101KCKGQLLIFG111ATNWDLIGRK121EVPKQQAAYR131NLGQNLWGPH141RYGCLAGVRV
151-200151RTVVSGSCAA161HSLLITTEGK171LWSWGRNEKG181QLGHGDTKRV191EAPRLIEGLS
201-250201HEVIVSAACG211RNHTLALTET221GSVFAFGENK231MGQLGLGNQT241DAVPSPAQIM
251-300251YNGQPITKMA261CGAEFSMIMD271CKGNLYSFGC281PEYGQLGHNS291DGKFIARAQR
301-350301IEYDCELVPR311RVAIFIEKTK321DGQILPVPNV331VVRDVACGAN341HTLVLDSQKR
351-400351VFSWGFGGYG361RLGHAEQKDE371MVPRLVKLFD381FPGRGASQIY391AGYTCSFAVS
401-450401EVGGLFFWGA411TNTSRESTMY421PKAVQDLCGW431RIRSLACGKS441SIIVAADEST
451-500451ISWGPSPTFG461ELGYGDHKPK471SSTAAQEVKT481LDGIFSEQVA491MGYSHSLVIA
501-522501RDESETEKEK511IKKLPEYNPR521TL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 42 | - | - | - |
Deep-Palm: 0.96
|
|
| 102 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.95
|
|
| 144 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.92
|
|
| 158 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.93
|
|
| 209 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.87
Deep-Palm: 0.94
|
|
| 261 | - | - | - |
Deep-Palm: 0.04
|
|
| 271 | - | - | - |
Deep-Palm: 0.04
|
|
| 280 | - | - | - |
Deep-Palm: 0.07
|
|
| 305 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.87
|
|
| 337 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.86
|
|
| 395 | - | - | - |
Deep-Palm: 0.37
|
|
| 428 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.87
|
| 437 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.84
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
2
LNCaP
Specificity: 0.250
2/2 (100.0%)
2
PC3
Specificity: 0.250
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.125
1/1 (100.0%)
1
U937 cell
Specificity: 0.125
1/1 (100.0%)
1
HeLa cell
Specificity: 0.125
1/1 (100.0%)
1
293T cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 374 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 384 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 384 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| ? | ? → ? | 0.001764 | SNP | Nonstop Mutation | LUAD |
| 428* | C → ? | 0.002294 | SNP | Nonsense Mutation | OV |