Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9QYB1 Clic4 Chloride intracellular channel protein 4 … Mus musculus (Mouse) 253 aa

Protein Details: Q9QYB1 (Clic4)

Protein Information
AccessionQ9QYB1
Protein NamesChloride intracellular channel protein 4 (mc3s5/mtCLIC) (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-)
Gene SymbolClic4
OrganismMus musculus (Mouse)
Length253 aa
IsoformsNo isoforms
Related PMIDs 28526873 34884899 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass)
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MALSMPLNGL11KEEDKEPLIE21LFVKAGSDGE31SIGNCPFSQR41LFMILWLKGV
51-10051VFSVTTVDLK61RKPADLQNLA71PGTHPPFITF81NSEVKTDVNK91IEEFLEEVLC
101-150101PPKYLKLSPK111HPESNTAGMD121IFAKFSAYIK131NSRPEANEAL141ERGLLKTLQK
151-200151LDEYLNSPLP161DEIDENSMED171IKFSTRRFLD181GDEMTLADCN191LLPKLHIVKV
201-250201VAKKYRNFDI211PKGMTGIWRY221LTNAYSRDEF231TNTCPSDKEV241EIAYSDVAKR
251-253251LTK
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
35 DBPTM CLIC, N-terminal domain CLIC-like N-terminal domain Thioredoxin-like superfamily CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED Glutaredoxin
Liver (28526873)
Brain (35358180)
Deep-Palm: 0.81
100 - - -
Deep-Palm: 0.95
189 - -
Brain (35358180)
Deep-Palm: 0.98
234 - -
Brain (35358180)
Deep-Palm: 0.28
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
6
Liver
Specificity: 0.222
6/6 (100.0%)
2
Testis
Specificity: 0.074
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.895
17
Brain tissue (Mass)
Specificity: 0.630
17/56 (30.4%)
2
Liver tissue (Mass)
Specificity: 0.074
2/8 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine