Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UBM7 | DHCR7 | 7-dehydrocholesterol reductase (7-DHC reductase) (EC … | Homo sapiens (Human) | 475 aa |
Protein Details: Q9UBM7 (DHCR7)
Protein Information
| Accession | Q9UBM7 |
|---|---|
| Protein Names | 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Cholesterol-5,6-epoxide hydrolase subunit DHCR7) (EC 3.3.2.11) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2) |
| Gene Symbol | DHCR7 |
| Organism | Homo sapiens (Human) |
| Length | 475 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAKSQPNIP11KAKSLDGVTN21DRTASQGQWG31RAWEVDWFSL41ASVIFLLLFA
51-10051PFIVYYFIMA61CDQYSCALTG71PVVDIVTGHA81RLSDIWAKTP91PITRKAAQLY
101-150101TLWVTFQVLL111YTSLPDFCHK121FLPGYVGGIQ131EGAVTPAGVV141NKYQINGLQA
151-200151WLLTHLLWFA161NAHLLSWFSP171TIIFDNWIPL181LWCANILGYA191VSTFAMVKGY
201-250201FFPTSARDCK211FTGNFFYNYM221MGIEFNPRIG231KWFDFKLFFN241GRPGIVAWTL
251-300251INLSFAAKQR261ELHSHVTNAM271VLVNVLQAIY281VIDFFWNETW291YLKTIDICHD
301-350301HFGWYLGWGD311CVWLPYLYTL321QGLYLVYHPV331QLSTPHAVGV341LLLGLVGYYI
351-400351FRVANHQKDL361FRRTDGRCLI371WGRKPKVIEC381SYTSADGQRH391HSKLLVSGFW
401-450401GVARHFNYVG411DLMGSLAYCL421ACGGGHLLPY431FYIIYMAILL441THRCLRDEHR
451-475451CASKYGRDWE461RYTAAVPYRL471LPGIF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 61 | - | - | - |
Deep-Palm: 0.22
|
|
| 66 | - | - | - |
Deep-Palm: 0.05
|
|
| 118 | - | - | - |
Deep-Palm: 0.91
|
|
| 183 | - | - | - |
Deep-Palm: 0.08
|
|
| 209 | - | - | - |
Deep-Palm: 0.05
|
|
| 298 | - | - | - |
Deep-Palm: 0.03
|
|
| 311 | - | - | - |
Deep-Palm: 0.05
|
|
| 368 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.76
|
|
| 380 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.88
Deep-Palm: 0.64
|
|
| 419 | - | - | - |
Deep-Palm: 0.13
|
|
| 422 | - | - | - |
Deep-Palm: 0.40
|
|
| 444 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.09
|
|
| 451 | - | - | - |
Deep-Palm: 0.85
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.300
3
LNCaP
Specificity: 0.300
3/3 (100.0%)
3
PC3
Specificity: 0.300
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.200
2/2 (100.0%)
2
293T cell
Specificity: 0.200
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 209 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 242 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 367 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 380 | C → C | 0.001887 | SNP | Silent | UCEC |
| 381 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 425 | G → C | 0.004219 | SNP | Missense Mutation | SARC |
| 451 | C → C | 0.005618 | SNP | Silent | PAAD |
| 462 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |