Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UBM7 | DHCR7; D7SR | 7-dehydrocholesterol reductase (7-DHC reductase) (EC … | Homo sapiens (Human) | 475 aa |
Protein Details: Q9UBM7 (DHCR7)
Protein Information
| Accession | Q9UBM7 |
|---|---|
| Protein Names | 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Cholesterol-5,6-epoxide hydrolase subunit DHCR7) (EC 3.3.2.11) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2) |
| Gene Symbol | DHCR7; D7SR |
| Organism | Homo sapiens (Human) |
| Length | 475 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.610
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.610
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.169
10/10 (100.0%)
10
293T cells
Specificity: 0.169
10/10 (100.0%)
3
PC3 cells
Specificity: 0.051
3/4 (75.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAAKSQPNIP11KAKSLDGVTN21DRTASQGQWG31RAWEVDWFSL41ASVIFLLLFA
51-10051PFIVYYFIMA61CDQYSCALTG71PVVDIVTGHA81RLSDIWAKTP91PITRKAAQLY
101-150101TLWVTFQVLL111YTSLPDFCHK121FLPGYVGGIQ131EGAVTPAGVV141NKYQINGLQA
151-200151WLLTHLLWFA161NAHLLSWFSP171TIIFDNWIPL181LWCANILGYA191VSTFAMVKGY
201-250201FFPTSARDCK211FTGNFFYNYM221MGIEFNPRIG231KWFDFKLFFN241GRPGIVAWTL
251-300251INLSFAAKQR261ELHSHVTNAM271VLVNVLQAIY281VIDFFWNETW291YLKTIDICHD
301-350301HFGWYLGWGD311CVWLPYLYTL321QGLYLVYHPV331QLSTPHAVGV341LLLGLVGYYI
351-400351FRVANHQKDL361FRRTDGRCLI371WGRKPKVIEC381SYTSADGQRH391HSKLLVSGFW
401-450401GVARHFNYVG411DLMGSLAYCL421ACGGGHLLPY431FYIIYMAILL441THRCLRDEHR
451-475451CASKYGRDWE461RYTAAVPYRL471LPGIF
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 368 | Prediction (Low) | - | - |
| 380 | Prediction (Medium) | - | - |
| 444 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 209 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 242 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 367 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 380 | C → C | 0.001887 | SNP | Silent | UCEC |
| 381 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 425 | G → C | 0.004219 | SNP | Missense Mutation | SARC |
| 451 | C → C | 0.005618 | SNP | Silent | PAAD |
| 462 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |