Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UIW2 | PLXNA1 | Plexin-A1 (Semaphorin receptor NOV) | Homo sapiens (Human) | 1896 aa |
Protein Details: Q9UIW2 (PLXNA1)
Protein Information
| Accession | Q9UIW2 |
|---|---|
| Protein Names | Plexin-A1 (Semaphorin receptor NOV) |
| Gene Symbol | PLXNA1 |
| Organism | Homo sapiens (Human) |
| Length | 1896 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPLPPRSLQV11LLLLLLLLLL21LPGMWAEAGL31PRAGGGSQPP41FRTFSASDWG
51-10051LTHLVVHEQT61GEVYVGAVNR71IYKLSGNLTL81LRAHVTGPVE91DNEKCYPPPS
101-150101VQSCPHGLGS111TDNVNKLLLL121DYAANRLLAC131GSASQGICQF141LRLDDLFKLG
151-200151EPHHRKEHYL161SSVQEAGSMA171GVLIAGPPGQ181GQAKLFVGTP191IDGKSEYFPT
201-250201LSSRRLMANE211EDADMFGFVY221QDEFVSSQLK231IPSDTLSKFP241AFDIYYVYSF
251-300251RSEQFVYYLT261LQLDTQLTSP271DAAGEHFFTS281KIVRLCVDDP291KFYSYVEFPI
301-350301GCEQAGVEYR311LVQDAYLSRP321GRALAHQLGL331AEDEDVLFTV341FAQGQKNRVK
351-400351PPKESALCLF361TLRAIKEKIK371ERIQSCYRGE381GKLSLPWLLN391KELGCINSPL
401-450401QIDDDFCGQD411FNQPLGGTVT421IEGTPLFVDK431DDGLTAVAAY441DYRGRTVVFA
451-500451GTRSGRIRKI461LVDLSNPGGR471PALAYESVVA481QEGSPILRDL491VLSPNHQYLY
501-550501AMTEKQVTRV511PVESCVQYTS521CELCLGSRDP531HCGWCVLHSI541CSRRDACERA
551-600551DEPQRFAADL561LQCVQLTVQP571RNVSVTMSQV581PLVLQAWNVP591DLSAGVNCSF
601-650601EDFTESESVL611EDGRIHCRSP621SAREVAPITR631GQGDQRVVKL641YLKSKETGKK
651-700651FASVDFVFYN661CSVHQSCLSC671VNGSFPCHWC681KYRHVCTHNV691ADCAFLEGRV
701-750701NVSEDCPQIL711PSTQIYVPVG721VVKPITLAAR731NLPQPQSGQR741GYECLFHIPG
751-800751SPARVTALRF761NSSSLQCQNS771SYSYEGNDVS781DLPVNLSVVW791NGNFVIDNPQ
801-850801NIQAHLYKCP811ALRESCGLCL821KADPRFECGW831CVAERRCSLR841HHCAADTPAS
851-900851WMHARHGSSR861CTDPKILKLS871PETGPRQGGT881RLTITGENLG891LRFEDVRLGV
901-950901RVGKVLCSPV911ESEYISAEQI921VCEIGDASSV931RAHDALVEVC941VRDCSPHYRA
951-1000951LSPKRFTFVT961PTFYRVSPSR971GPLSGGTWIG981IEGSHLNAGS991DVAVSVGGRP
1001-10501001CSFSWRNSRE1011IRCLTPPGQS1021PGSAPIIINI1031NRAQLTNPEV1041KYNYTEDPTI
1051-11001051LRIDPEWSIN1061SGGTLLTVTG1071TNLATVREPR1081IRAKYGGIER1091ENGCLVYNDT
1101-11501101TMVCRAPSVA1111NPVRSPPELG1121ERPDELGFVM1131DNVRSLLVLN1141STSFLYYPDP
1151-12001151VLEPLSPTGL1161LELKPSSPLI1171LKGRNLLPPA1181PGNSRLNYTV1191LIGSTPCTLT
1201-12501201VSETQLLCEA1211PNLTGQHKVT1221VRAGGFEFSP1231GTLQVYSDSL1241LTLPAIVGIG
1251-13001251GGGGLLLLVI1261VAVLIAYKRK1271SRDADRTLKR1281LQLQMDNLES1291RVALECKEAF
1301-13501301AELQTDIHEL1311TNDLDGAGIP1321FLDYRTYAMR1331VLFPGIEDHP1341VLKEMEVQAN
1351-14001351VEKSLTLFGQ1361LLTKKHFLLT1371FIRTLEAQRS1381FSMRDRGNVA1391SLIMTALQGE
1401-14501401MEYATGVLKQ1411LLSDLIEKNL1421ESKNHPKLLL1431RRTESVAEKM1441LTNWFTFLLY
1451-15001451KFLKECAGEP1461LFMLYCAIKQ1471QMEKGPIDAI1481TGEARYSLSE1491DKLIRQQIDY
1501-15501501KTLTLNCVNP1511ENENAPEVPV1521KGLDCDTVTQ1531AKEKLLDAAY1541KGVPYSQRPK
1551-16001551AADMDLEWRQ1561GRMARIILQD1571EDVTTKIDND1581WKRLNTLAHY1591QVTDGSSVAL
1601-16501601VPKQTSAYNI1611SNSSTFTKSL1621SRYESMLRTA1631SSPDSLRSRT1641PMITPDLESG
1651-17001651TKLWHLVKNH1661DHLDQREGDR1671GSKMVSEIYL1681TRLLATKGTL1691QKFVDDLFET
1701-17501701IFSTAHRGSA1711LPLAIKYMFD1721FLDEQADKHQ1731IHDADVRHTW1741KSNCLPLRFW
1751-18001751VNVIKNPQFV1761FDIHKNSITD1771ACLSVVAQTF1781MDSCSTSEHK1791LGKDSPSNKL
1801-18501801LYAKDIPNYK1811SWVERYYADI1821AKMPAISDQD1831MSAYLAEQSR1841LHLSQFNSMS
1851-18961851ALHEIYSYIT1861KYKDEILAAL1871EKDEQARRQR1881LRSKLEQVVD1891TMALSS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 95 | - | - | - |
Deep-Palm: 0.68
|
|
| 104 | - | - | - |
Deep-Palm: 0.70
|
|
| 130 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.97
|
|
| 138 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.92
|
|
| 286 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.65
|
|
| 302 | - | - | - |
Deep-Palm: 0.63
|
|
| 358 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.95
|
|
| 376 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 395 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.89
|
|
| 407 | - | - | - |
Deep-Palm: 0.15
|
|
| 515 | - | - | - |
Deep-Palm: 0.41
|
|
| 521 | - | - | - |
Deep-Palm: 0.07
|
|
| 524 | - | - | - |
Deep-Palm: 0.06
|
|
| 532 | - | - | - |
Deep-Palm: 0.07
|
|
| 535 | - | - | - |
Deep-Palm: 0.35
|
|
| 541 | - | - | - |
Deep-Palm: 0.10
|
|
| 547 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.56
|
|
| 563 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.88
|
|
| 598 | - | - | - |
Deep-Palm: 0.74
|
|
| 617 | - | - | - |
Deep-Palm: 0.87
|
|
| 661 | - | - | - |
Deep-Palm: 0.05
|
|
| 667 | - | - | - |
Deep-Palm: 0.01
|
|
| 670 | - | - | - |
Deep-Palm: 0.01
|
|
| 677 | - | - | - |
Deep-Palm: 0.02
|
|
| 680 | - | - | - |
Deep-Palm: 0.02
|
|
| 686 | - | - | - |
Deep-Palm: 0.03
|
|
| 693 | - | - | - |
Deep-Palm: 0.04
|
|
| 706 | - | - | - |
Deep-Palm: 0.69
|
|
| 744 | - | - | - |
Deep-Palm: 0.91
|
|
| 767 | - | - | - |
Deep-Palm: 0.78
|
|
| 809 | - | - | - |
Deep-Palm: 0.66
|
|
| 816 | SWISSPALM DBPTM CYSMODDB | Plexin repeat | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.47
|
| 819 | SWISSPALM DBPTM CYSMODDB | Plexin repeat | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.51
|
| 828 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.54
|
|
| 831 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.64
|
|
| 837 | - | - | - |
Deep-Palm: 0.10
|
|
| 843 | - | - | - |
Deep-Palm: 0.09
|
|
| 861 | - | - | - |
Deep-Palm: 0.77
|
|
| 907 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.97
|
|
| 922 | - | - | - |
Deep-Palm: 0.83
|
|
| 940 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.91
|
|
| 944 | - | - | - |
Deep-Palm: 0.80
|
|
| 1001 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.53
|
|
| 1013 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.36
|
|
| 1094 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.50
|
|
| 1104 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.63
|
|
| 1197 | - | - | - |
Deep-Palm: 0.43
|
|
| 1208 | - | - | - |
Deep-Palm: 0.72
|
|
| 1296 | - | - | - |
Deep-Palm: 0.84
|
|
| 1456 | - | - | - |
Deep-Palm: 0.28
|
|
| 1466 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.70
|
|
| 1507 | - | - | - |
Deep-Palm: 0.72
|
|
| 1525 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.97
|
|
| 1744 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.32
|
|
| 1772 | - | - | - |
Deep-Palm: 0.11
|
|
| 1784 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.61
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
frontal cortex
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 286 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 302 | C → C | 0.002545 | SNP | Silent | GBM |
| 310 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 378 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 458 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 571 | R → C | 0.015152 | SNP | Missense Mutation | KICH |
| 661 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 673 | G → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 686 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 949 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 989 | G → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 989 | G → C | 0.001969 | SNP | Missense Mutation | LGG |
| 1009 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 1013 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 1077 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1105 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1182 | G → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 1197 | C → C | 0.002288 | SNP | Silent | STAD |
| 1208 | C → C | 0.005618 | SNP | Silent | PAAD |
| 1236 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1269 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1291 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1384 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 1431 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1456 | C → C | 0.003460 | SNP | Silent | CESC |
| 1559 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1737 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 1737 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 1737 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1747 | L → Cfs*5 | 0.008130 | DEL | Frame Shift Del | THYM |
| 1750 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1784 | C → F | 0.001969 | SNP | Missense Mutation | HNSC |