Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UJ83-4 | HACL1 | 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) … | Homo sapiens (Human) | 518 aa |
Protein Details: Q9UJ83-4 (HACL1)
Protein Information
| Accession | Q9UJ83-4 |
|---|---|
| Protein Names | 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) |
| Gene Symbol | HACL1 |
| Organism | Homo sapiens (Human) |
| Length | 518 aa |
| Isoforms | |
| Related PMIDs | 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPDSNFAERS11EEQVSGAKVI21AQALKTQDVE31YIFGIVGIPV41TEIAIAAQQL
51-10051GIKYIGMRNE61QAACYAASAI71GYLTSRPGVC81LVVSGPGLIH91ALGGMANANM
101-150101NCWPLLVIGG111SSERNQETMG121AFQEFPQAVR131SSIYGRPGAC141YVDIPADFVN
151-200151LQVNVNSIKY161MERCMSPPIS171MAETSAVCTA181ASVIRNAKQP191LLIIGKGAAY
201-250201AHAEESIKKL211VEQYKLPFLP221TPMGKGVVPD231NHPYCVGAAR241SRALQFADVI
251-300251VLFGARLNWI261LHFGLPPRYQ271PDVKFIQVDI281CAEELGNNVK291PAVTLLGNIH
301-350301AVTKQELASK311KSLPMNYYTV321FYHVQEQLPR331DCFVVSEGAN341TMDIGRTVLQ
351-400351NYLPRHRLDA361GTFGTMGVGL371GFAIAAAVVA381KDRSPGQWII391CVEGDSAFGF
401-450401SGMEVETICR411YNLPIILLVV421NNNGIYQGFD431TDTWKEMLKF441QDATAVVPPM
451-500451CLLPNSHYEQ461VMTAFGGKGY471FVQTPEELQK481SLRQSLADTT491KPSLINIMIE
501-518501PQATRKAQDF511HWLTRSNM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 64 | - | - | - |
Deep-Palm: 0.87
|
|
| 80 | - | - | - |
Deep-Palm: 0.96
|
|
| 102 | - | - | - |
Deep-Palm: 0.75
|
|
| 131 | - | - | - |
Deep-Palm: 0.89
|
|
| 166 | - | - | - |
Deep-Palm: 0.84
|
|
| 190 | - | - | - |
Deep-Palm: 0.08
|
|
| 204 | - | - | - |
Deep-Palm: 0.91
|
|
| 261 | - | - | - |
Deep-Palm: 0.84
|
|
| 307 | - | - | - |
Deep-Palm: 0.96
|
|
| 392 | - | - | - |
Deep-Palm: 0.47
|
|
| 451 | - | - | - |
Deep-Palm: 0.94
|
|
| 469 | - | - | - |
Deep-Palm: 0.85
|
|
| 511 | - | - | - |
Deep-Palm: 0.58
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 140 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 166 | C → C | 0.001887 | SNP | Silent | UCEC |
| 183 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 223 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 289 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 301 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 392 | C → C | 0.001887 | SNP | Silent | UCEC |
| 432 | F → C | 0.005435 | SNP | Missense Mutation | ESCA |