Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UNK0 | STX8 | Syntaxin-8 | Homo sapiens (Human) | 236 aa |
Protein Details: Q9UNK0 (STX8)
Protein Information
| Accession | Q9UNK0 |
|---|---|
| Protein Names | Syntaxin-8 |
| Gene Symbol | STX8 |
| Organism | Homo sapiens (Human) |
| Length | 236 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 25914232 26111759 31251020 31382980 32651440 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPDPWFSTY11DSTCQIAQEI21AEKIQQRNQY31ERKGEKAPKL41TVTIRALLQN
51-10051LKEKIALLKD61LLLRAVSTHQ71ITQLEGDRRQ81NLLDDLVTRE91RLLLASFKNE
101-150101GAEPDLIRSS111LMSEEAKRGA121PNPWLFEEPE131ETRGLGFDEI141RQQQQKIIQE
151-200151QDAGLDALSS161IISRQKQMGQ171EIGNELDEQN181EIIDDLANLV191ENTDEKLRNE
201-236201TRRVNMVDRK211SASCGMIMVI221LLLLVAIVVV231AVWPTN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 14 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.87
Deep-Palm: 0.14
|
|
| 214 | DBPTM SWISSPALM | SNARE domain | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
8
Jurkat T cell
Specificity: 0.381
8/8 (100.0%)
4
LNCaP
Specificity: 0.190
4/4 (100.0%)
3
Primary T cell
Specificity: 0.143
3/3 (100.0%)
2
CEM 174 cell
Specificity: 0.095
2/2 (100.0%)
1
U937 cell
Specificity: 0.048
1/1 (100.0%)
1
heart
Specificity: 0.048
1/1 (100.0%)
1
DU145 cell
Specificity: 0.048
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.048
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 198 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 198 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 198 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |