Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9UNK9 ANGEL1 RNA 2',3'-cyclic phosphatase ANGEL1 (EC … Homo sapiens (Human) 670 aa

Protein Details: Q9UNK9 (ANGEL1)

Protein Information
AccessionQ9UNK9
Protein NamesRNA 2',3'-cyclic phosphatase ANGEL1 (EC 3.-.-.-)
Gene SymbolANGEL1
OrganismHomo sapiens (Human)
Length670 aa
IsoformsNo isoforms
Related PMIDs 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MIASCLCYLL11LPATRLFRAL21SDAFFTCRKN31VLLANSSSPQ41VEGDFAMAPR
51-10051GPEQEECEGL61LQQWREEGLS71QVLSTASEGP81LIDKGLAQSS91LALLMDNPGE
101-150101ENAASEDRWS111SRQLSDLRAA121ENLDEPFPEM131LGEEPLLEVE141GVEGSMWAAI
151-200151PMQSEPQYAD161CAALPVGALA171TEQWEEDPAV181LAWSIAPEPV191PQEEASIWPF
201-250201EGLGQLQPPA211VEIPYHEILW221REWEDFSTQP231DAQGLKAGDG241PQFQFTLMSY
251-300251NILAQDLMQQ261SSELYLHCHP271DILNWNYRFV281NLMQEFQHWD291PDILCLQEVQ
301-350301EDHYWEQLEP311SLRMMGFTCF321YKRRTGCKTD331GCAVCYKPTR341FRLLCASPVE
351-400351YFRPGLELLN361RDNVGLVLLL371QPLVPEGLGQ381VSVAPLCVAN391THILYNPRRG
401-450401DVKLAQMAIL411LAEVDKVARL421SDGSHCPIIL431CGDLNSVPDS441PLYNFIRDGE
451-500451LQYHGMPAWK461VSGQEDFSHQ471LYQRKLQAPL481WPSSLGITDC491CQYVTSCHPK
501-550501RSERRKYGRD511FLLRFRFCSI521ACQRPVGLVL531MEGVTDTKPE541RPAGWAESVL
551-600551EEDASELEPA561FSRTVGTIQH571CLHLTSVYTH581FLPQRGRPEV591TTMPLGLGMT
601-650601VDYIFFSAES611CENGNRTDHR621LYRDGTLKLL631GRLSLLSEEI641LWAANGLPNP
651-670651FCSSDHLCLL661ASFGMEVTAP
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
5 SWISSPALM DBPTM CYSMODDB - - -
GPS-Palm: 0.96
Deep-Palm: 0.06
7 SWISSPALM DBPTM CYSMODDB - - -
GPS-Palm: 0.95
Deep-Palm: 0.09
27 -
HeLa (37611173)
-
GPS-Palm: 0.93
Deep-Palm: 0.96
57 - - -
Deep-Palm: 0.96
161 - - -
Deep-Palm: 0.70
268 - - -
Deep-Palm: 0.09
295 - - -
Deep-Palm: 0.11
319 - - -
GPS-Palm: 0.95
Deep-Palm: 0.54
327 - - -
GPS-Palm: 0.73
Deep-Palm: 0.14
332 - - -
GPS-Palm: 0.88
Deep-Palm: 0.60
335 - - -
GPS-Palm: 0.91
Deep-Palm: 0.71
345 - - -
GPS-Palm: 0.88
Deep-Palm: 0.94
387 - - -
Deep-Palm: 0.98
426 - - -
GPS-Palm: 0.78
Deep-Palm: 0.78
431 - - -
Deep-Palm: 0.54
490 - - -
Deep-Palm: 0.58
491 - - -
Deep-Palm: 0.74
497 - - -
GPS-Palm: 0.66
Deep-Palm: 0.41
518 - - -
GPS-Palm: 0.93
Deep-Palm: 0.88
522 - - -
GPS-Palm: 0.92
Deep-Palm: 0.86
571 - - -
Deep-Palm: 0.63
611 - - -
Deep-Palm: 0.30
652 - - -
Deep-Palm: 0.53
658 - - -
Deep-Palm: 0.17
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
LNCaP
Specificity: 0.800
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.200
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
109 W → C 0.001764 SNP Missense Mutation LUAD
110 S → C 0.002033 SNP Missense Mutation LUSC
265 Y → C 0.019608 SNP Missense Mutation CHOL
327 C → Lfs*7 0.002294 INS Nonsense Mutation OV
497 C → C 0.001887 SNP Silent UCEC
505 R → C 0.002288 SNP Missense Mutation STAD
505 R → C 0.001887 SNP Missense Mutation UCEC
518 C → Y 0.006993 SNP Missense Mutation LAML
561 F → Cfs*50 0.001969 INS Frame Shift Ins HNSC
585 R → C 0.002288 SNP Missense Mutation STAD
611 C → R 0.002294 SNP Missense Mutation OV
622 Y → C 0.001764 SNP Missense Mutation LUAD