Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UPY5 | SLC7A11 | Cystine/glutamate transporter (Amino acid transport … | Homo sapiens (Human) | 501 aa |
Protein Details: Q9UPY5 (SLC7A11)
Protein Information
| Accession | Q9UPY5 |
|---|---|
| Protein Names | Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) |
| Gene Symbol | SLC7A11 |
| Organism | Homo sapiens (Human) |
| Length | 501 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 29733200 31251020 36430497 |
| Database Sources | CysModDB dbPTM PTMD SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
12
LNCaP cells
Specificity: 0.667
12/46 (26.1%)
4
HAP1 cells
Specificity: 0.222
4/10 (40.0%)
2
Cerebral cortex
Specificity: 0.111
2/4 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MVRKPVVSTI11SKGGYLQGNV21NGRLPSLGNK31EPPGQEKVQL41KRKVTLLRGV
51-10051SIIIGTIIGA61GIFISPKGVL71QNTGSVGMSL81TIWTVCGVLS91LFGALSYAEL
101-150101GTTIKKSGGH111YTYILEVFGP121LPAFVRVWVE131LLIIRPAATA141VISLAFGRYI
151-200151LEPFFIQCEI161PELAIKLITA171VGITVVMVLN181SMSVSWSARI191QIFLTFCKLT
201-250201AILIIIVPGV211MQLIKGQTQN221FKDAFSGRDS231SITRLPLAFY241YGMYAYAGWF
251-300251YLNFVTEEVE261NPEKTIPLAI271CISMAIVTIG281YVLTNVAYFT291TINAEELLLS
301-350301NAVAVTFSER311LLGNFSLAVP321IFVALSCFGS331MNGGVFAVSR341LFYVASREGH
351-400351LPEILSMIHV361RKHTPLPAVI371VLHPLTMIML381FSGDLDSLLN391FLSFARWLFI
401-450401GLAVAGLIYL411RYKCPDMHRP421FKVPLFIPAL431FSFTCLFMVA441LSLYSDPFST
451-500451GIGFVITLTG461VPAYYLFIIW471DKKPRWFRIM481SEKITRTLQI491ILEVVPEEDK
501-501501L
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 158 | Prediction (Low) | - | - |
| 197 | Prediction (Medium) | - | - |
| 271 | Prediction (Low) | - | - |
| 327 | Experimental CYSMODDB SWISSPALM PTMD DBPTM | Amino acid permease | 29575903 |
| 414 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 119 | G → C | 0.002033 | SNP | Missense Mutation | THCA |
| 135 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |