Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UPY5 | SLC7A11 | Cystine/glutamate transporter (Amino acid transport … | Homo sapiens (Human) | 501 aa |
Protein Details: Q9UPY5 (SLC7A11)
Protein Information
| Accession | Q9UPY5 |
|---|---|
| Protein Names | Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) |
| Gene Symbol | SLC7A11 |
| Organism | Homo sapiens (Human) |
| Length | 501 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 |
| Database Sources | PTMDCysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVRKPVVSTI11SKGGYLQGNV21NGRLPSLGNK31EPPGQEKVQL41KRKVTLLRGV
51-10051SIIIGTIIGA61GIFISPKGVL71QNTGSVGMSL81TIWTVCGVLS91LFGALSYAEL
101-150101GTTIKKSGGH111YTYILEVFGP121LPAFVRVWVE131LLIIRPAATA141VISLAFGRYI
151-200151LEPFFIQCEI161PELAIKLITA171VGITVVMVLN181SMSVSWSARI191QIFLTFCKLT
201-250201AILIIIVPGV211MQLIKGQTQN221FKDAFSGRDS231SITRLPLAFY241YGMYAYAGWF
251-300251YLNFVTEEVE261NPEKTIPLAI271CISMAIVTIG281YVLTNVAYFT291TINAEELLLS
301-350301NAVAVTFSER311LLGNFSLAVP321IFVALSCFGS331MNGGVFAVSR341LFYVASREGH
351-400351LPEILSMIHV361RKHTPLPAVI371VLHPLTMIML381FSGDLDSLLN391FLSFARWLFI
401-450401GLAVAGLIYL411RYKCPDMHRP421FKVPLFIPAL431FSFTCLFMVA441LSLYSDPFST
451-500451GIGFVITLTG461VPAYYLFIIW471DKKPRWFRIM481SEKITRTLQI491ILEVVPEEDK
501-501501L
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 86 | - | - | - |
Deep-Palm: 0.89
|
|
| 158 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.92
|
|
| 197 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.43
|
|
| 271 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.63
|
|
| 327 | SWISSPALM PTMD DBPTM CYSMODDB | Amino acid permease | - | - |
Deep-Palm: 0.80
|
| 414 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.94
|
|
| 435 | - | - | - |
Deep-Palm: 0.55
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP
Specificity: 0.500
1/1 (100.0%)
1
HAP1 cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 119 | G → C | 0.002033 | SNP | Missense Mutation | THCA |
| 135 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |