Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9UQD0 | SCN8A | Sodium channel protein type 8 … | Homo sapiens (Human) | 1980 aa |
Protein Details: Q9UQD0 (SCN8A)
Protein Information
| Accession | Q9UQD0 |
|---|---|
| Protein Names | Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) |
| Gene Symbol | SCN8A |
| Organism | Homo sapiens (Human) |
| Length | 1980 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAARLLAPPG11PDSFKPFTPE21SLANIERRIA31ESKLKKPPKA41DGSHREDDED
51-10051SKPKPNSDLE61AGKSLPFIYG71DIPQGLVAVP81LEDFDPYYLT91QKTFVVLNRG
101-150101KTLFRFSATP111ALYILSPFNL121IRRIAIKILI131HSVFSMIIMC141TILTNCVFMT
151-200151FSNPPDWSKN161VEYTFTGIYT171FESLVKIIAR181GFCIDGFTFL191RDPWNWLDFS
201-250201VIMMAYITEF211VNLGNVSALR221TFRVLRALKT231ISVIPGLKTI241VGALIQSVKK
251-300251LSDVMILTVF261CLSVFALIGL271QLFMGNLRNK281CVVWPINFNE291SYLENGTKGF
301-350301DWEEYINNKT311NFYTVPGMLE321PLLCGNSSDA331GQCPEGYQCM341KAGRNPNYGY
351-400351TSFDTFSWAF361LALFRLMTQD371YWENLYQLTL381RAAGKTYMIF391FVLVIFVGSF
401-450401YLVNLILAVV411AMAYEEQNQA421TLEEAEQKEA431EFKAMLEQLK441KQQEEAQAAA
451-500451MATSAGTVSE461DAIEEEGEEG471GGSPRSSSEI481SKLSSKSAKE491RRNRRKKRKQ
501-550501KELSEGEEKG511DPEKVFKSES521EDGMRRKAFR531LPDNRIGRKF541SIMNQSLLSI
551-600551PGSPFLSRHN561SKSSIFSFRG571PGRFRDPGSE581NEFADDEHST591VEESEGRRDS
601-650601LFIPIRARER611RSSYSGYSGY621SQGSRSSRIF631PSLRRSVKRN641STVDCNGVVS
651-700651LIGGPGSHIG661GRLLPEATTE671VEIKKKGPGS681LLVSMDQLAS691YGRKDRINSI
701-750701MSVVTNTLVE711ELEESQRKCP721PCWYKFANTF731LIWECHPYWI741KLKEIVNLIV
751-800751MDPFVDLAIT761ICIVLNTLFM771AMEHHPMTPQ781FEHVLAVGNL791VFTGIFTAEM
801-850801FLKLIAMDPY811YYFQEGWNIF821DGFIVSLSLM831ELSLADVEGL841SVLRSFRLLR
851-900851VFKLAKSWPT861LNMLIKIIGN871SVGALGNLTL881VLAIIVFIFA891VVGMQLFGKS
901-950901YKECVCKINQ911DCELPRWHMH921DFFHSFLIVF931RVLCGEWIET941MWDCMEVAGQ
951-1000951AMCLIVFMMV961MVIGNLVVLN971LFLALLLSSF981SADNLAATDD991DGEMNNLQIS
1001-10501001VIRIKKGVAW1011TKLKVHAFMQ1021AHFKQREADE1031VKPLDELYEK1041KANCIANHTG
1051-11001051ADIHRNGDFQ1061KNGNGTTSGI1071GSSVEKYIID1081EDHMSFINNP1091NLTVRVPIAV
1101-11501101GESDFENLNT1111EDVSSESDPE1121GSKDKLDDTS1131SSEGSTIDIK1141PEVEEVPVEQ
1151-12001151PEEYLDPDAC1161FTEGCVQRFK1171CCQVNIEEGL1181GKSWWILRKT1191CFLIVEHNWF
1201-12501201ETFIIFMILL1211SSGALAFEDI1221YIEQRKTIRT1231ILEYADKVFT1241YIFILEMLLK
1251-13001251WTAYGFVKFF1261TNAWCWLDFL1271IVAVSLVSLI1281ANALGYSELG1291AIKSLRTLRA
1301-13501301LRPLRALSRF1311EGMRVVVNAL1321VGAIPSIMNV1331LLVCLIFWLI1341FSIMGVNLFA
1351-14001351GKYHYCFNET1361SEIRFEIEDV1371NNKTECEKLM1381EGNNTEIRWK1391NVKINFDNVG
1401-14501401AGYLALLQVA1411TFKGWMDIMY1421AAVDSRKPDE1431QPKYEDNIYM1441YIYFVIFIIF
1451-15001451GSFFTLNLFI1461GVIIDNFNQQ1471KKKFGGQDIF1481MTEEQKKYYN1491AMKKLGSKKP
1501-15501501QKPIPRPLNK1511IQGIVFDFVT1521QQAFDIVIMM1531LICLNMVTMM1541VETDTQSKQM
1551-16001551ENILYWINLV1561FVIFFTCECV1571LKMFALRHYY1581FTIGWNIFDF1591VVVILSIVGM
1601-16501601FLADIIEKYF1611VSPTLFRVIR1621LARIGRILRL1631IKGAKGIRTL1641LFALMMSLPA
1651-17001651LFNIGLLLFL1661VMFIFSIFGM1671SNFAYVKHEA1681GIDDMFNFET1691FGNSMICLFQ
1701-17501701ITTSAGWDGL1711LLPILNRPPD1721CSLDKEHPGS1731GFKGDCGNPS1741VGIFFFVSYI
1751-18001751IISFLIVVNM1761YIAIILENFS1771VATEESADPL1781SEDDFETFYE1791IWEKFDPDAT
1801-18501801QFIEYCKLAD1811FADALEHPLR1821VPKPNTIELI1831AMDLPMVSGD1841RIHCLDILFA
1851-19001851FTKRVLGDSG1861ELDILRQQME1871ERFVASNPSK1881VSYEPITTTL1891RRKQEEVSAV
1901-19501901VLQRAYRGHL1911ARRGFICKKT1921TSNKLENGGT1931HREKKESTPS1941TASLPSYDSV
1951-19801951TKPEKEKQQR1961AEEGRRERAK1971RQKEVRESKC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 140 | - | - | - |
Deep-Palm: 0.02
|
|
| 146 | - | - | - |
Deep-Palm: 0.02
|
|
| 183 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.24
|
|
| 261 | - | - | - |
Deep-Palm: 0.70
|
|
| 281 | - | - | - |
Deep-Palm: 0.63
|
|
| 324 | - | - | - |
Deep-Palm: 0.16
|
|
| 333 | - | - | - |
Deep-Palm: 0.08
|
|
| 339 | - | - | - |
Deep-Palm: 0.03
|
|
| 645 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.94
|
|
| 719 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.48
|
|
| 722 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.22
|
|
| 735 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.08
|
|
| 762 | - | - | - |
Deep-Palm: 0.02
|
|
| 904 | - | - | - |
Deep-Palm: 0.08
|
|
| 906 | - | - | - |
Deep-Palm: 0.04
|
|
| 912 | - | - | - |
Deep-Palm: 0.03
|
|
| 934 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.05
|
|
| 944 | - | - | - |
Deep-Palm: 0.05
|
|
| 953 | - | - | - |
Deep-Palm: 0.03
|
|
| 1044 | - | - | - |
Deep-Palm: 0.75
|
|
| 1160 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.32
|
|
| 1165 | SWISSPALM | Sodium ion transport-associated | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.28
|
| 1171 | SWISSPALM | Sodium ion transport-associated | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.20
|
| 1172 | SWISSPALM | Sodium ion transport-associated | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.35
|
| 1191 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.48
|
|
| 1265 | - | - | - |
Deep-Palm: 0.16
|
|
| 1334 | - | - | - |
Deep-Palm: 0.68
|
|
| 1356 | - | - | - |
Deep-Palm: 0.06
|
|
| 1376 | - | - | - |
Deep-Palm: 0.15
|
|
| 1533 | - | - | - |
Deep-Palm: 0.03
|
|
| 1567 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.02
|
|
| 1569 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.02
|
|
| 1697 | - | - | - |
Deep-Palm: 0.10
|
|
| 1721 | - | - | - |
Deep-Palm: 0.93
|
|
| 1736 | - | - | - |
Deep-Palm: 0.48
|
|
| 1806 | - | - | - |
Deep-Palm: 0.63
|
|
| 1844 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.91
|
|
| 1917 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.72
|
|
| 1980 | SWISSPALM | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Cerebral Cortex (Mass)
Specificity: 1.000
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 28 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 106 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 236 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 324 | C → Y | 0.002294 | SNP | Missense Mutation | OV |
| 365 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 467 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 492 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 540 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 625 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 722 | C → C | 0.002506 | SNP | Silent | COAD |
| 1003 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1441 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1518 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1626 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 1717 | R → C | 0.019608 | SNP | Missense Mutation | CHOL |
| 1892 | R → C | 0.019608 | SNP | Missense Mutation | CHOL |
| 1892 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1917 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |