Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9WVK8 | Cyp46a1 | Cholesterol 24-hydroxylase (CH24H) (EC 1.14.14.25) … | Mus musculus (Mouse) | 500 aa |
Protein Details: Q9WVK8 (Cyp46a1)
Protein Information
| Accession | Q9WVK8 |
|---|---|
| Protein Names | Cholesterol 24-hydroxylase (CH24H) (EC 1.14.14.25) (Cholesterol 24-monooxygenase) (Cholesterol 24S-hydroxylase) (Cytochrome P450 46A1) |
| Gene Symbol | Cyp46a1 |
| Organism | Mus musculus (Mouse) |
| Length | 500 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 29733200 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSPGLLLLGS11AVLLAFGLCC21TFVHRARSRY31EHIPGPPRPS41FLLGHLPYFW
51-10051KKDEDCGRVL61QDVFLDWAKK71YGPVVRVNVF81YKTSVIVTSP91ESVKKFLMST
101-150101KYNKDSKMYR111ALQTVFGERL121FGQGLVSECD131YGRWYKQRKV141MDLAFSRSSL
151-200151VSLMETFNEK161AEQLVEILEA171KADGQTPVSM181QDMLTCATID191ILAKAAFGME
201-250201TSMLLGAQKP211LSQAVKVMLE221GISASRNTLA231KFMPGKRKQL241REIRESIRLL
251-300251RQVGKDWVQR261RREALKRGED271MPADILTQIL281KAEEGAQDDE291VLLDNFVTFF
301-350301IAGHETSANH311LAFTVMELSR321QPEIVARLQA331EVDEVVGSKR341HLDYEDLGRL
351-400351QYLSQVLKES361LRLYPPAWGT371FRLLEEETLI381DGVRVPGNTP391LLFSTYVMGR
401-450401MDTYFEDPLT411FNPDRFGPGA421PKPRFTYFPF431SLGHRSCIGQ441QFAQMEVKVV
451-500451MAKLLQRIEF461RLVPGQRFGL471QEQATLKPLD481PVLCTLRPRG491WQPAPPPPPC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 19 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.98
|
|
| 20 | Cholesterol 24-hydroxylase | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 56 | - | - | - |
Deep-Palm: 0.76
|
|
| 129 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.95
|
|
| 186 | - | - | - |
Deep-Palm: 0.86
|
|
| 437 | Cytochrome P450 |
Liver
(28526873)
|
Brain
(35358180)
|
Deep-Palm: 0.38
|
|
| 484 | DBPTM | - |
Liver
(28526873)
| - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
| 500 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
Liver
Specificity: 0.200
1/1 (100.0%)
1
Brain
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Brain tissue (Mass)
Specificity: 0.600
3/56 (5.4%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.