Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y289 | SLC5A6 | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin … | Homo sapiens (Human) | 635 aa |
Protein Details: Q9Y289 (SLC5A6)
Protein Information
| Accession | Q9Y289 |
|---|---|
| Protein Names | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6) |
| Gene Symbol | SLC5A6 |
| Organism | Homo sapiens (Human) |
| Length | 635 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSVGVSTSAP11LSPTSGTSVG21MSTFSIMDYV31VFVLLLVLSL41AIGLYHACRG
51-10051WGRHTVGELL61MADRKMGCLP71VALSLLATFQ81SAVAILGVPS91EIYRFGTQYW
101-150101FLGCCYFLGL111LIPAHIFIPV121FYRLHLTSAY131EYLELRFNKT141VRVCGTVTFI
151-200151FQMVIYMGVV161LYAPSLALNA171VTGFDLWLSV181LALGIVCTVY191TALGGLKAVI
201-250201WTDVFQTLVM211FLGQLAVIIV221GSAKVGGLGR231VWAVASQHGR241ISGFELDPDP
251-300251FVRHTFWTLA261FGGVFMMLSL271YGVNQAQVQR281YLSSRTEKAA291VLSCYAVFPF
301-350301QQVSLCVGCL311IGLVMFAYYQ321EYPMSIQQAQ331AAPDQFVLYF341VMDLLKGLPG
351-400351LPGLFIACLF361SGSLSTISSA371FNSLATVTME381DLIRPWFPEF391SEARAIMLSR
401-450401GLAFGYGLLC411LGMAYISSQM421GPVLQAAISI431FGMVGGPLLG441LFCLGMFFPC
451-500451ANPPGAVVGL461LAGLVMAFWI471GIGSIVTSMG481SSMPPSPSNG491SSFSLPTNLT
501-550501VATVTTLMPL511TTFSKPTGLQ521RFYSLSYLWY531SAHNSTTVIV541VGLIVSLLTG
551-600551RMRGRSLNPA561TIYPVLPKLL571SLLPLSCQKR581LHCRSYGQDH591LDTGLFPEKP
601-635601RNGVLGDSRD611KEAMALDGTA621YQGSSSTCIL631QETSL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 48 | Sodium:Solute Symporter (SSF) | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.98
|
|
| 68 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.97
|
|
| 104 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.15
|
|
| 105 | - | - | - |
Deep-Palm: 0.18
|
|
| 144 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.61
|
|
| 187 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.97
|
|
| 294 | - | - | - |
Deep-Palm: 0.85
|
|
| 306 | - | - | - |
Deep-Palm: 0.22
|
|
| 309 | - | - | - |
Deep-Palm: 0.12
|
|
| 358 | - | - | - |
Deep-Palm: 0.95
|
|
| 410 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.89
|
|
| 443 | - | - | - |
Deep-Palm: 0.80
|
|
| 450 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.95
|
|
| 577 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(37611173)
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.98
|
| 583 | - | - | - |
Deep-Palm: 0.98
|
|
| 628 | - | - | - |
Deep-Palm: 0.08
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
LNCaP
Specificity: 0.500
4/4 (100.0%)
1
HAP1 cell
Specificity: 0.125
1/1 (100.0%)
1
U937 cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP cells (Mass)
Specificity: 0.125
1/4 (25.0%)
1
Cerebral Cortex (Mass)
Specificity: 0.125
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 29 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 39 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 48 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 295 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 450 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 486 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 577 | C → Y | 0.005587 | SNP | Missense Mutation | PCPG |
| 628 | C → C | 0.002288 | SNP | Silent | STAD |