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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9Y289 SLC5A6; SMVT Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin … Homo sapiens (Human) 635 aa

Protein Details: Q9Y289 (SLC5A6)

Protein Information
Accession Q9Y289
Protein Names Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6)
Gene Symbol SLC5A6; SMVT
Organism Homo sapiens (Human)
Length 635 aa
Isoforms No isoforms
Related PMIDs 19137006 19801377 29575903 29733200 31251020 31382980 32944167 37611173
Database Sources CysModDB dbPTM
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.691
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
38
LNCaP cells
Specificity: 0.691
38/46 (82.6%)
6
Jurkat T cells
Specificity: 0.109
6/25 (24.0%)
4
PC3 cells
Specificity: 0.073
4/4 (100.0%)
4
HAP1 cells
Specificity: 0.073
4/10 (40.0%)
2
DU145 cells
Specificity: 0.036
2/2 (100.0%)
1
U937 cells
Specificity: 0.018
1/1 (100.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSVGVSTSAP11LSPTSGTSVG21MSTFSIMDYV31VFVLLLVLSL41AIGLYHACRG
51-10051WGRHTVGELL61MADRKMGCLP71VALSLLATFQ81SAVAILGVPS91EIYRFGTQYW
101-150101FLGCCYFLGL111LIPAHIFIPV121FYRLHLTSAY131EYLELRFNKT141VRVCGTVTFI
151-200151FQMVIYMGVV161LYAPSLALNA171VTGFDLWLSV181LALGIVCTVY191TALGGLKAVI
201-250201WTDVFQTLVM211FLGQLAVIIV221GSAKVGGLGR231VWAVASQHGR241ISGFELDPDP
251-300251FVRHTFWTLA261FGGVFMMLSL271YGVNQAQVQR281YLSSRTEKAA291VLSCYAVFPF
301-350301QQVSLCVGCL311IGLVMFAYYQ321EYPMSIQQAQ331AAPDQFVLYF341VMDLLKGLPG
351-400351LPGLFIACLF361SGSLSTISSA371FNSLATVTME381DLIRPWFPEF391SEARAIMLSR
401-450401GLAFGYGLLC411LGMAYISSQM421GPVLQAAISI431FGMVGGPLLG441LFCLGMFFPC
451-500451ANPPGAVVGL461LAGLVMAFWI471GIGSIVTSMG481SSMPPSPSNG491SSFSLPTNLT
501-550501VATVTTLMPL511TTFSKPTGLQ521RFYSLSYLWY531SAHNSTTVIV541VGLIVSLLTG
551-600551RMRGRSLNPA561TIYPVLPKLL571SLLPLSCQKR581LHCRSYGQDH591LDTGLFPEKP
601-635601RNGVLGDSRD611KEAMALDGTA621YQGSSSTCIL631QETSL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
48 Prediction (Low) - -
68 Prediction (High) - -
104 Prediction (Low) - -
144 Prediction (Medium) - -
187 Prediction (Low) - -
410 Prediction (Low) - -
450 Prediction (Low) - -
577 Experimental CYSMODDB DBPTM Prediction (High) - 29575903, 37611173, 19801377
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
29 Y → C 0.002506 SNP Missense Mutation COAD
39 S → C 0.002427 SNP Missense Mutation BLCA
48 C → Y 0.001887 SNP Missense Mutation UCEC
295 Y → C 0.003559 SNP Missense Mutation KIRP
450 C → F 0.002033 SNP Missense Mutation LUSC
486 S → C 0.001014 SNP Missense Mutation BRCA
577 C → Y 0.005587 SNP Missense Mutation PCPG
628 C → C 0.002288 SNP Silent STAD