Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y2I7 | PIKFYVE | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate … | Homo sapiens (Human) | 2098 aa |
Protein Details: Q9Y2I7 (PIKFYVE)
Protein Information
| Accession | Q9Y2I7 |
|---|---|
| Protein Names | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) |
| Gene Symbol | PIKFYVE |
| Organism | Homo sapiens (Human) |
| Length | 2098 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATDDKTSPT11LDSANDLPRS21PTSPSHLTHF31KPLTPDQDEP41PFKSAYSSFV
51-10051NLFRFNKERA61EGGQGEQQPL71SGSWTSPQLP81SRTQSVRSPT91PYKKQLNEEL
101-150101QRRSSALDTR111RKAEPTFGGH121DPRTAVQLRS131LSTVLKRLKE141IMEGKSQDSD
151-200151LKQYWMPDSQ161CKECYDCSEK171FTTFRRRHHC181RLCGQIFCSR191CCNQEIPGKF
201-250201MGYTGDLRAC211TYCRKIALSY221AHSTDSNSIG231EDLNALSDSA241CSVSVLDPSE
251-300251PRTPVGSRKA261SRNIFLEDDL271AWQSLIHPDS281SNTPLSTRLV291SVQEDAGKSP
301-350301ARNRSASITN311LSLDRSGSPM321VPSYETSVSP331QANRTYVRTE341TTEDERKILL
351-400351DSVQLKDLWK361KICHHSSGME371FQDHRYWLRT381HPNCIVGKEL391VNWLIRNGHI
401-450401ATRAQAIAIG411QAMVDGRWLD421CVSHHDQLFR431DEYALYRPLQ441STEFSETPSP
451-500451DSDSVNSVEG461HSEPSWFKDI471KFDDSDTEQI481AEEGDDNLAN491SASPSKRTSV
501-550501SSFQSTVDSD511SAASISLNVE521LDNVNFHIKK531PSKYPHVPPH541PADQKEYLIS
551-600551DTGGQQLSIS561DAFIKESLFN571RRVEEKSKEL581PFTPLGWHHN591NLELLREENG
601-650601EKQAMERLLS611ANHNHMMALL621QQLLHSDSLS631SSWRDIIVSL641VCQVVQTVRP
651-700651DVKNQDDDMD661IRQFVHIKKI671PGGKKFDSVV681VNGFVCTKNI691AHKKMSSCIK
701-750701NPKILLLKCS711IEYLYREETK721FTCIDPIVLQ731EREFLKNYVQ741RIVDVRPTLV
751-800751LVEKTVSRIA761QDMLLEHGIT771LVINVKSQVL781ERISRMTQGD791LVMSMDQLLT
801-850801KPHLGTCHKF811YMQIFQLPNE821QTKTLMFFEG831CPQHLGCTIK841LRGGSDYELA
851-900851RVKEILIFMI861CVAYHSQLEI871SFLMDEFAMP881PTLMQNPSFH891SLIEGRGHEG
901-950901AVQEQYGGGS911IPWDPDIPPE921SLPCDDSSLL931ELRIVFEKGE941QENKNLPQAV
951-1000951ASVKHQEHST961TACPAGLPCA971FFAPVPESLL981PLPVDDQQDA991LGSEQPETLQ
1001-10501001QTVVLQDPKS1011QIRAFRDPLQ1021DDTGLYVTEE1031VTSSEDKRKT1041YSLAFKQELK
1051-11001051DVILCISPVI1061TFREPFLLTE1071KGMRCSTRDY1081FAEQVYWSPL1091LNKEFKEMEN
1101-11501101RRKKQLLRDL1111SGLQGMNGSI1121QAKSIQVLPS1131HELVSTRIAE1141HLGDSQSLGR
1151-12001151MLADYRARGG1161RIQPKNSDPF1171AHSKDASSTS1181SGQSGSKNEG1191DEERGLILSD
1201-12501201AVWSTKVDCL1211NPINHQRLCV1221LFSSSSAQSS1231NAPSACVSPW1241IVTMEFYGKN
1251-13001251DLTLGIFLER1261YCFRPSYQCP1271SMFCDTPMVH1281HIRRFVHGQG1291CVQIILKELD
1301-13501301SPVPGYQHTI1311LTYSWCRICK1321QVTPVVALSN1331ESWSMSFAKY1341LELRFYGHQY
1351-14001351TRRANAEPCG1361HSIHHDYHQY1371FSYNQMVASF1381SYSPIRLLEV1391CVPLPKIFIK
1401-14501401RQAPLKVSLL1411QDLKDFFQKV1421SQVYVAIDER1431LASLKTDTFS1441KTREEKMEDI
1451-15001451FAQKEMEEGE1461FKNWIEKMQA1471RLMSSSVDTP1481QQLQSVFESL1491IAKKQSLCEV
1501-15501501LQAWNNRLQD1511LFQQEKGRKR1521PSVPPSPGRL1531RQGEESKISA1541MDASPRNISP
1551-16001551GLQNGEKEDR1561FLTTLSSQSS1571TSSTHLQLPT1581PPEVMSEQSV1591GGPPELDTAS
1601-16501601SSEDVFDGHL1611LGSTDSQVKE1621KSTMKAIFAN1631LLPGNSYNPI1641PFPFDPDKHY
1651-17001651LMYEHERVPI1661AVCEKEPSSI1671IAFALSCKEY1681RNALEELSKA1691TQWNSAEEGL
1701-17501701PTNSTSDSRP1711KSSSPIRLPE1721MSGGQTNRTT1731ETEPQPTKKA1741SGMLSFFRGT
1751-18001751AGKSPDLSSQ1761KRETLRGADS1771AYYQVGQTGK1781EGTENQGVEP1791QDEVDGGDTQ
1801-18501801KKQLINPHVE1811LQFSDANAKF1821YCRLYYAGEF1831HKMREVILDS1841SEEDFIRSLS
1851-19001851HSSPWQARGG1861KSGAAFYATE1871DDRFILKQMP1881RLEVQSFLDF1891APHYFNYITN
1901-19501901AVQQKRPTAL1911AKILGVYRIG1921YKNSQNNTEK1931KLDLLVMENL1941FYGRKMAQVF
1951-20001951DLKGSLRNRN1961VKTDTGKESC1971DVVLLDENLL1981KMVRDNPLYI1991RSHSKAVLRT
2001-20502001SIHSDSHFLS2011SHLIIDYSLL2021VGRDDTSNEL2031VVGIIDYIRT2041FTWDKKLEMV
2051-20982051VKSTGILGGQ2061GKMPTVVSPE2071LYRTRFCEAM2081DKYFLMVPDH2091WTGLGLNC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 161 | - | - | - |
Deep-Palm: 0.03
|
|
| 164 | - | - | - |
Deep-Palm: 0.03
|
|
| 167 | - | - | - |
Deep-Palm: 0.02
|
|
| 180 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.02
|
|
| 183 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.03
|
|
| 188 | - | - | - |
Deep-Palm: 0.02
|
|
| 191 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.02
|
|
| 192 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.03
|
|
| 210 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.75
|
|
| 213 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.62
|
|
| 241 | - | - | - |
Deep-Palm: 0.93
|
|
| 363 | - | - | - |
Deep-Palm: 0.42
|
|
| 384 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.31
|
|
| 421 | - | - | - |
Deep-Palm: 0.44
|
|
| 642 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.84
|
|
| 686 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.45
|
|
| 698 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.80
|
|
| 709 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.83
|
|
| 723 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.47
|
|
| 807 | - | - | - |
Deep-Palm: 0.09
|
|
| 831 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.72
|
|
| 837 | - | - | - |
Deep-Palm: 0.90
|
|
| 861 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.32
|
|
| 924 | - | - | - |
Deep-Palm: 0.95
|
|
| 963 | - | - | - |
Deep-Palm: 0.83
|
|
| 969 | - | - | - |
Deep-Palm: 0.90
|
|
| 1055 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.94
|
|
| 1075 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.82
|
|
| 1209 | - | - | - |
Deep-Palm: 0.93
|
|
| 1219 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.51
|
|
| 1236 | - | - | - |
Deep-Palm: 0.40
|
|
| 1262 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.04
|
|
| 1269 | - | - | - |
Deep-Palm: 0.02
|
|
| 1274 | - | - | - |
Deep-Palm: 0.02
|
|
| 1291 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.57
|
|
| 1316 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.23
|
|
| 1319 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.10
|
|
| 1359 | - | - | - |
Deep-Palm: 0.02
|
|
| 1391 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.93
|
|
| 1498 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 1663 | - | - | - |
Deep-Palm: 0.53
|
|
| 1677 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.79
Deep-Palm: 0.97
|
|
| 1822 | - | - | - |
Deep-Palm: 0.27
|
|
| 1970 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.95
|
|
| 2077 | - | - | - |
Deep-Palm: 0.24
|
|
| 2098 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 54 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 74 | W → C | 0.002294 | SNP | Missense Mutation | OV |
| 119 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 189 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 192 | C → C | 0.002288 | SNP | Silent | STAD |
| 210 | C → W | 0.001887 | SNP | Missense Mutation | UCEC |
| 213 | C → C | 0.002288 | SNP | Silent | STAD |
| 241 | C → C | 0.001887 | SNP | Silent | UCEC |
| 346 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 376 | Y → C | 0.001969 | SNP | Missense Mutation | LGG |
| 417 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 491 | S → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 662 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 683 | G → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 789 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 789 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 827 | F → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 1075 | C → Ifs*43 | 0.002545 | INS | Frame Shift Ins | GBM |
| 1076 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1111 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1182 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1203 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1226 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1288 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1372 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1476 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 1728 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 1822 | C → G | 0.002506 | SNP | Missense Mutation | COAD |
| 1262* | C → ? | 0.006993 | SNP | Nonsense Mutation | LAML |