Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y2X3 | NOP58 | Nucleolar protein 58 (Nucleolar protein … | Homo sapiens (Human) | 529 aa |
Protein Details: Q9Y2X3 (NOP58)
Protein Information
| Accession | Q9Y2X3 |
|---|---|
| Protein Names | Nucleolar protein 58 (Nucleolar protein 5) |
| Gene Symbol | NOP58 |
| Organism | Homo sapiens (Human) |
| Length | 529 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLVLFETSVG11YAIFKVLNEK21KLQEVDSLWK31EFETPEKANK41IVKLKHFEKF
51-10051QDTAEALAAF61TALMEGKINK71QLKKVLKKIV81KEAHEPLAVA91DAKLGGVIKE
101-150101KLNLSCIHSP111VVNELMRGIR121SQMDGLIPGV131EPREMAAMCL141GLAHSLSRYR
151-200151LKFSADKVDT161MIVQAISLLD171DLDKELNNYI181MRCREWYGWH191FPELGKIISD
201-250201NLTYCKCLQK211VGDRKNYASA221KLSELLPEEV231EAEVKAAAEI241SMGTEVSEED
251-300251ICNILHLCTQ261VIEISEYRTQ271LYEYLQNRMM281AIAPNVTVMV291GELVGARLIA
301-350301HAGSLLNLAK311HAASTVQILG321AEKALFRALK331SRRDTPKYGL341IYHASLVGQT
351-400351SPKHKGKISR361MLAAKTVLAI371RYDAFGEDSS381SAMGVENRAK391LEARLRTLED
401-450401RGIRKISGTG411KALAKTEKYE421HKSEVKTYDP431SGDSTLPTCS441KKRKIEQVDK
451-500451EDEITEKKAK461KAKIKVKVEE471EEEEKVAEEE481ETSVKKKKKR491GKKKHIKEEP
501-529501LSEEEPCTST511AIASPEKKKK521KKKKRENED
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 106 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 139 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 183 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.45
|
|
| 205 | SWISSPALM DBPTM CYSMODDB | snoRNA binding domain fibrillarin |
SW480 cell line
(26865113)
| - |
GPS-Palm: 0.95
Deep-Palm: 0.80
|
| 207 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.83
|
|
| 252 | - | - | - |
Deep-Palm: 0.36
|
|
| 258 | - | - | - |
Deep-Palm: 0.51
|
|
| 439 | - |
SW480 cell line
(26865113)
| - |
Deep-Palm: 0.64
|
|
| 507 | - | - | - |
Deep-Palm: 0.83
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.333
2/2 (100.0%)
1
U937 cell
Specificity: 0.167
1/1 (100.0%)
1
293T cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 120 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 120 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 149 | Y → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 342 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 371 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 431 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 439 | C → S | 0.003559 | SNP | Missense Mutation | KIRP |
| 443 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |