Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y2X7 | GIT1 | ARF GTPase-activating protein GIT1 (ARF … | Homo sapiens (Human) | 761 aa |
Protein Details: Q9Y2X7 (GIT1)
Protein Information
| Accession | Q9Y2X7 |
|---|---|
| Protein Names | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) |
| Gene Symbol | GIT1 |
| Organism | Homo sapiens (Human) |
| Length | 761 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSRKGPRAEV11CADCSAPDPG21WASISRGVLV31CDECCSVHRS41LGRHISIVKH
51-10051LRHSAWPPTL61LQMVHTLASN71GANSIWEHSL81LDPAQVQSGR91RKANPQDKVH
101-150101PIKSEFIRAK111YQMLAFVHKL121PCRDDDGVTA131KDLSKQLHSS141VRTGNLETCL
151-200151RLLSLGAQAN161FFHPEKGTTP171LHVAAKAGQT181LQAELLVVYG191ADPGSPDVNG
201-250201RTPIDYARQA211GHHELAERLV221ECQYELTDRL231AFYLCGRKPD241HKNGHYIIPQ
251-300251MADSLDLSEL261AKAAKKKLQA271LSNRLFEELA281MDVYDEVDRR291ENDAVWLATQ
301-350301NHSTLVTERS311AVPFLPVNPE321YSATRNQGRQ331KLARFNAREF341ATLIIDILSE
351-400351AKRRQQGKSL361SSPTDNLELS371LRSQSDLDDQ381HDYDSVASDE391DTDQEPLRST
401-450401GATRSNRARS411MDSSDLSDGA421VTLQEYLELK431KALATSEAKV441QQLMKVNSSL
451-500451SDELRRLQRE461IHKLQAENLQ471LRQPPGPVPT481PPLPSERAEH491TPMAPGGSTH
501-550501RRDRQAFSMY511EPGSALKPFG521GPPGDELTTR531LQPFHSTELE541DDAIYSVHVP
551-600551AGLYRIRKGV561SASAVPFTPS571SPLLSCSQEG581SRHTSKLSRH591GSGADSDYEN
601-650601TQSGDPLLGL611EGKRFLELGK621EEDFHPELES631LDGDLDPGLP641STEDVILKTE
651-700651QVTKNIQELL661RAAQEFKHDS671FVPCSEKIHL681AVTEMASLFP691KRPALEPVRS
701-750701SLRLLNASAY711RLQSECRKTV721PPEPGAPVDF731QLLTQQVIQC741AYDIAKAAKQ
751-761751LVTITTREKK761Q
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 11 | ArfGAP domain superfamily ARF GTPase-activating protein Git-like Arf GTPase activating protein ARFGAP/RecO-like zinc finger | - | - |
Deep-Palm: 0.09
|
|
| 14 | ArfGAP domain superfamily ARF GTPase-activating protein Git-like Arf GTPase activating protein ARFGAP/RecO-like zinc finger | - | - |
Deep-Palm: 0.85
|
|
| 31 | ArfGAP domain superfamily Arf GTPase activating protein ARF GTPase-activating protein Git-like ARFGAP/RecO-like zinc finger | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.63
|
|
| 34 | ArfGAP domain superfamily Arf GTPase activating protein ARF GTPase-activating protein Git-like ARFGAP/RecO-like zinc finger | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.53
|
|
| 35 | ArfGAP domain superfamily Arf GTPase activating protein ARF GTPase-activating protein Git-like ARFGAP/RecO-like zinc finger | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.40
|
|
| 122 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.72
Deep-Palm: 0.82
|
|
| 149 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 222 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.91
|
|
| 235 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.45
|
|
| 576 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.94
|
|
| 674 | - | - | - |
Deep-Palm: 0.86
|
|
| 716 | - | - | - |
Deep-Palm: 0.94
|
|
| 740 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.88
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
frontal cortex
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.667
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 398 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 504 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |