Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y3Q4 | HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel … | Homo sapiens (Human) | 1203 aa |
Protein Details: Q9Y3Q4 (HCN4)
Protein Information
| Accession | Q9Y3Q4 |
|---|---|
| Protein Names | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
| Gene Symbol | HCN4 |
| Organism | Homo sapiens (Human) |
| Length | 1203 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDKLPPSMRK11RLYSLPQQVG21AKAWIMDEEE31DAEEEGAGGR41QDPSRRSIRL
51-10051RPLPSPSPSA61AAGGTESRSS71ALGAADSEGP81ARGAGKSSTN91GDCRRFRGSL
101-150101ASLGSRGGGS111GGTGSGSSHG121HLHDSAEERR131LIAEGDASPG141EDRTPPGLAA
151-200151EPERPGASAQ161PAASPPPPQQ171PPQPASASCE181QPSVDTAIKV191EGGAAAGDQI
201-250201LPEAEVRLGQ211AGFMQRQFGA221MLQPGVNKFS231LRMFGSQKAV241EREQERVKSA
251-300251GFWIIHPYSD261FRFYWDLTML271LLMVGNLIII281PVGITFFKDE291NTTPWIVFNV
301-350301VSDTFFLIDL311VLNFRTGIVV321EDNTEIILDP331QRIKMKYLKS341WFMVDFISSI
351-400351PVDYIFLIVE361TRIDSEVYKT371ARALRIVRFT381KILSLLRLLR391LSRLIRYIHQ
401-450401WEEIFHMTYD411LASAVVRIVN421LIGMMLLLCH431WDGCLQFLVP441MLQDFPDDCW
451-500451VSINNMVNNS461WGKQYSYALF471KAMSHMLCIG481YGRQAPVGMS491DVWLTMLSMI
501-550501VGATCYAMFI511GHATALIQSL521DSSRRQYQEK531YKQVEQYMSF541HKLPPDTRQR
551-600551IHDYYEHRYQ561GKMFDEESIL571GELSEPLREE581IINFNCRKLV591ASMPLFANAD
601-650601PNFVTSMLTK611LRFEVFQPGD621YIIREGTIGK631KMYFIQHGVV641SVLTKGNKET
651-700651KLADGSYFGE661ICLLTRGRRT671ASVRADTYCR681LYSLSVDNFN691EVLEEYPMMR
701-750701RAFETVALDR711LDRIGKKNSI721LLHKVQHDLN731SGVFNYQENE741IIQQIVQHDR
751-800751EMAHCAHRVQ761AAASATPTPT771PVIWTPLIQA781PLQAAAATTS791VAIALTHHPR
801-850801LPAAIFRPPP811GSGLGNLGAG821QTPRHLKRLQ831SLIPSALGSA841SPASSPSQVD
851-900851TPSSSSFHIQ861QLAGFSAPAG871LSPLLPSSSS881SPPPGACGSP891SAPTPSAGVA
901-950901ATTIAGFGHF911HKALGGSLSS921SDSPLLTPLQ931PGARSPQAAQ941PSPAPPGARG
951-1000951GLGLPEHFLP961PPPSSRSPSS971SPGQLGQPPG981ELSLGLATGP991LSTPETPPRQ
1001-10501001PEPPSLVAGA1011SGGASPVGFT1021PRGGLSPPGH1031SPGPPRTFPS1041APPRASGSHG
1051-11001051SLLLPPASSP1061PPPQVPQRRG1071TPPLTPGRLT1081QDLKLISASQ1091PALPQDGAQT
1101-11501101LRRASPHSSG1111ESMAAFPLFP1121RAGGGSGGSG1131SSGGLGPPGR1141PYGAIPGQHV
1151-12001151TLPRKTSSGS1161LPPPLSLFGA1171RATSSGGPPL1181TAGPQREPGA1191RPEPVRSKLP
1201-12031201SNL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 93 | SWISSPALM | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.98
|
| 179 | SWISSPALM | - | - | - |
Deep-Palm: 0.76
|
| 429 | - | - | - |
Deep-Palm: 0.24
|
|
| 434 | - | - | - |
Deep-Palm: 0.07
|
|
| 449 | - | - | - |
Deep-Palm: 0.03
|
|
| 478 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.22
|
|
| 505 | - | - | - |
Deep-Palm: 0.18
|
|
| 586 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.93
|
|
| 662 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
|
| 679 | - | - | - |
Deep-Palm: 0.95
|
|
| 755 | - | - | - |
Deep-Palm: 0.22
|
|
| 887 | - | - | - |
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 253 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 315 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 378 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 387 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 387 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 390 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 390 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 525 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 537 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 680 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 774 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 807 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 951 | G → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 1196 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 755* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |
| 755* | C → ? | 0.005618 | SNP | Nonsense Mutation | PAAD |