Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y487 | ATP6V0A2 | V-type proton ATPase 116 kDa … | Homo sapiens (Human) | 856 aa |
Protein Details: Q9Y487 (ATP6V0A2)
Protein Information
| Accession | Q9Y487 |
|---|---|
| Protein Names | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) |
| Gene Symbol | ATP6V0A2 |
| Organism | Homo sapiens (Human) |
| Length | 856 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 29733200 31251020 31382980 32944167 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.709
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
39
LNCaP cells
Specificity: 0.709
39/46 (84.8%)
4
PC3 cells
Specificity: 0.073
4/4 (100.0%)
4
T cells
Specificity: 0.073
4/4 (100.0%)
4
HAP1 cells
Specificity: 0.073
4/10 (40.0%)
3
Jurkat T cells
Specificity: 0.055
3/25 (12.0%)
1
U937 cells
Specificity: 0.018
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGSLFRSETM11CLAQLFLQSG21TAYECLSALG31EKGLVQFRDL41NQNVSSFQRK
51-10051FVGEVKRCEE61LERILVYLVQ71EINRADIPLP81EGEASPPAPP91LKQVLEMQEQ
101-150101LQKLEVELRE111VTKNKEKLRK121NLLELIEYTH131MLRVTKTFVK141RNVEFEPTYE
151-200151EFPSLESDSL161LDYSCMQRLG171AKLGFVSGLI181NQGKVEAFEK191MLWRVCKGYT
201-250201IVSYAELDES211LEDPETGEVI221KWYVFLISFW231GEQIGHKVKK241ICDCYHCHVY
251-300251PYPNTAEERR261EIQEGLNTRI271QDLYTVLHKT281EDYLRQVLCK291AAESVYSRVI
301-350301QVKKMKAIYH311MLNMCSFDVT321NKCLIAEVWC331PEADLQDLRR341ALEEGSRESG
351-400351ATIPSFMNII361PTKETPPTRI371RTNKFTEGFQ381NIVDAYGVGS391YREVNPALFT
401-450401IITFPFLFAV411MFGDFGHGFV421MFLFALLLVL431NENHPRLNQS441QEIMRMFFNG
451-500451RYILLLMGLF461SVYTGLIYND471CFSKSVNLFG481SGWNVSAMYS491SSHPPAEHKK
501-550501MVLWNDSVVR511HNSILQLDPS521IPGVFRGPYP531LGIDPIWNLA541TNRLTFLNSF
551-600551KMKMSVILGI561IHMTFGVILG571IFNHLHFRKK581FNIYLVSIPE591LLFMLCIFGY
601-650601LIFMIFYKWL611VFSAETSRVA621PSILIEFINM631FLFPASKTSG641LYTGQEYVQR
651-700651VLLVVTALSV661PVLFLGKPLF671LLWLHNGRSC681FGVNRSGYTL691IRKDSEEEVS
701-750701LLGSQDIEEG711NHQVEDGCRE721MACEEFNFGE731ILMTQVIHSI741EYCLGCISNT
751-800751ASYLRLWALS761LAHAQLSDVL771WAMLMRVGLR781VDTTYGVLLL791LPVIALFAVL
801-850801TIFILLIMEG811LSAFLHAIRL821HWVEFQNKFY831VGAGTKFVPF841SFSLLSSKFN
851-856851NDDSVA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 11 | Prediction (Medium) | - | - |
| 25 | Prediction (Low) | - | - |
| 58 | Prediction (Medium) | - | - |
| 165 | Prediction (Low) | - | - |
| 196 | Prediction (Low) | - | - |
| 289 | Prediction (Medium) | - | - |
| 471 | Prediction (Low) | - | - |
| 680 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | 37611173 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 193 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 223 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 274 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 350 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 371 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 463 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 480 | G → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 537 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 596 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 627 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |