Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y487 | ATP6V0A2 | V-type proton ATPase 116 kDa … | Homo sapiens (Human) | 856 aa |
Protein Details: Q9Y487 (ATP6V0A2)
Protein Information
| Accession | Q9Y487 |
|---|---|
| Protein Names | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) |
| Gene Symbol | ATP6V0A2 |
| Organism | Homo sapiens (Human) |
| Length | 856 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 29733200 31251020 31382980 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGSLFRSETM11CLAQLFLQSG21TAYECLSALG31EKGLVQFRDL41NQNVSSFQRK
51-10051FVGEVKRCEE61LERILVYLVQ71EINRADIPLP81EGEASPPAPP91LKQVLEMQEQ
101-150101LQKLEVELRE111VTKNKEKLRK121NLLELIEYTH131MLRVTKTFVK141RNVEFEPTYE
151-200151EFPSLESDSL161LDYSCMQRLG171AKLGFVSGLI181NQGKVEAFEK191MLWRVCKGYT
201-250201IVSYAELDES211LEDPETGEVI221KWYVFLISFW231GEQIGHKVKK241ICDCYHCHVY
251-300251PYPNTAEERR261EIQEGLNTRI271QDLYTVLHKT281EDYLRQVLCK291AAESVYSRVI
301-350301QVKKMKAIYH311MLNMCSFDVT321NKCLIAEVWC331PEADLQDLRR341ALEEGSRESG
351-400351ATIPSFMNII361PTKETPPTRI371RTNKFTEGFQ381NIVDAYGVGS391YREVNPALFT
401-450401IITFPFLFAV411MFGDFGHGFV421MFLFALLLVL431NENHPRLNQS441QEIMRMFFNG
451-500451RYILLLMGLF461SVYTGLIYND471CFSKSVNLFG481SGWNVSAMYS491SSHPPAEHKK
501-550501MVLWNDSVVR511HNSILQLDPS521IPGVFRGPYP531LGIDPIWNLA541TNRLTFLNSF
551-600551KMKMSVILGI561IHMTFGVILG571IFNHLHFRKK581FNIYLVSIPE591LLFMLCIFGY
601-650601LIFMIFYKWL611VFSAETSRVA621PSILIEFINM631FLFPASKTSG641LYTGQEYVQR
651-700651VLLVVTALSV661PVLFLGKPLF671LLWLHNGRSC681FGVNRSGYTL691IRKDSEEEVS
701-750701LLGSQDIEEG711NHQVEDGCRE721MACEEFNFGE731ILMTQVIHSI741EYCLGCISNT
751-800751ASYLRLWALS761LAHAQLSDVL771WAMLMRVGLR781VDTTYGVLLL791LPVIALFAVL
801-850801TIFILLIMEG811LSAFLHAIRL821HWVEFQNKFY831VGAGTKFVPF841SFSLLSSKFN
851-856851NDDSVA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 11 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.07
|
|
| 25 | V-type ATPase, V0 complex, 116kDa subunit family | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.97
|
|
| 58 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.91
|
|
| 165 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 196 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.83
|
|
| 242 | - | - | - |
Deep-Palm: 0.02
|
|
| 244 | - | - | - |
Deep-Palm: 0.02
|
|
| 247 | - | - | - |
Deep-Palm: 0.03
|
|
| 289 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.95
|
|
| 315 | - | - | - |
Deep-Palm: 0.03
|
|
| 323 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.15
|
|
| 330 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.96
|
|
| 471 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.45
|
|
| 596 | - | - | - |
Deep-Palm: 0.07
|
|
| 680 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.87
Deep-Palm: 0.96
|
| 718 | - | - | - |
Deep-Palm: 0.05
|
|
| 723 | - | - | - |
Deep-Palm: 0.05
|
|
| 743 | - | - | - |
Deep-Palm: 0.39
|
|
| 746 | - | - | - |
Deep-Palm: 0.74
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.211
4
LNCaP
Specificity: 0.200
4/4 (100.0%)
4
PC3
Specificity: 0.200
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.200
4/4 (100.0%)
3
Primary T cell
Specificity: 0.150
3/3 (100.0%)
2
Jurkat T cell
Specificity: 0.100
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.050
1/1 (100.0%)
1
U937 cell
Specificity: 0.050
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.050
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 193 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 223 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 274 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 350 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 371 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 463 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 480 | G → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 537 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 596 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 627 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |