Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y4P3 | TBL2 | Transducin beta-like protein 2 (WS … | Homo sapiens (Human) | 447 aa |
Protein Details: Q9Y4P3 (TBL2)
Protein Information
| Accession | Q9Y4P3 |
|---|---|
| Protein Names | Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) |
| Gene Symbol | TBL2 |
| Organism | Homo sapiens (Human) |
| Length | 447 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MELSQMSELM11GLSVLLGLLA21LMATAAVARG31WLRAGEERSG41RPACQKANGF
51-10051PPDKSSGSKK61QKQYQRIRKE71KPQQHNFTHR81LLAAALKSHS91GNISCMDFSS
101-150101NGKYLATCAD111DRTIRIWSTK121DFLQREHRSM131RANVELDHAT141LVRFSPDCRA
151-200151FIVWLANGDT161LRVFKMTKRE171DGGYTFTATP181EDFPKKHKAP191VIDIGIANTG
201-250201KFIMTASSDT211TVLIWSLKGQ221VLSTINTNQM231NNTHAAVSPC241GRFVASCGFT
251-300251PDVKVWEVCF261GKKGEFQEVV271RAFELKGHSA281AVHSFAFSND291SRRMASVSKD
301-350301GTWKLWDTDV311EYKKKQDPYL321LKTGRFEEAA331GAAPCRLALS341PNAQVLALAS
351-400351GSSIHLYNTR361RGEKEECFER371VHGECIANLS381FDITGRFLAS391CGDRAVRLFH
401-447401NTPGHRAMVE411EMQGHLKRAS421NESTRQRLQQ431QLTQAQETLK441SLGALKK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 44 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.95
|
| 95 | - | - | - |
Deep-Palm: 0.47
|
|
| 108 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.15
|
|
| 148 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.89
|
|
| 240 | - | - | - |
Deep-Palm: 0.10
|
|
| 247 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.70
|
|
| 259 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.93
|
|
| 335 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 367 | - | - | - |
Deep-Palm: 0.30
|
|
| 375 | - | - | - |
Deep-Palm: 0.78
|
|
| 391 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
LNCaP
Specificity: 0.600
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.200
1/1 (100.0%)
1
U937 cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 115 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 128 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 325 | R → C | 0.002506 | SNP | Missense Mutation | COAD |