Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y4P3 | TBL2; WBSCR13; UNQ563/PRO1125 | Transducin beta-like protein 2 (WS … | Homo sapiens (Human) | 447 aa |
Protein Details: Q9Y4P3 (TBL2)
Protein Information
| Accession | Q9Y4P3 |
|---|---|
| Protein Names | Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) |
| Gene Symbol | TBL2; WBSCR13; UNQ563/PRO1125 |
| Organism | Homo sapiens (Human) |
| Length | 447 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.818
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.818
36/46 (78.3%)
4
HAP1 cells
Specificity: 0.091
4/10 (40.0%)
3
PC3 cells
Specificity: 0.068
3/4 (75.0%)
1
U937 cells
Specificity: 0.023
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MELSQMSELM11GLSVLLGLLA21LMATAAVARG31WLRAGEERSG41RPACQKANGF
51-10051PPDKSSGSKK61QKQYQRIRKE71KPQQHNFTHR81LLAAALKSHS91GNISCMDFSS
101-150101NGKYLATCAD111DRTIRIWSTK121DFLQREHRSM131RANVELDHAT141LVRFSPDCRA
151-200151FIVWLANGDT161LRVFKMTKRE171DGGYTFTATP181EDFPKKHKAP191VIDIGIANTG
201-250201KFIMTASSDT211TVLIWSLKGQ221VLSTINTNQM231NNTHAAVSPC241GRFVASCGFT
251-300251PDVKVWEVCF261GKKGEFQEVV271RAFELKGHSA281AVHSFAFSND291SRRMASVSKD
301-350301GTWKLWDTDV311EYKKKQDPYL321LKTGRFEEAA331GAAPCRLALS341PNAQVLALAS
351-400351GSSIHLYNTR361RGEKEECFER371VHGECIANLS381FDITGRFLAS391CGDRAVRLFH
401-447401NTPGHRAMVE411EMQGHLKRAS421NESTRQRLQQ431QLTQAQETLK441SLGALKK
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 44 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | - | - |
| 108 | Prediction (High) | - | - |
| 148 | Prediction (Low) | - | - |
| 247 | Prediction (Medium) | - | - |
| 259 | Prediction (Medium) | - | - |
| 335 | Prediction (Medium) | - | - |
| 391 | Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 115 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 128 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 325 | R → C | 0.002506 | SNP | Missense Mutation | COAD |