Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y4W6 | AFG3L2 | Mitochondrial inner membrane m-AAA protease … | Homo sapiens (Human) | 797 aa |
Protein Details: Q9Y4W6 (AFG3L2)
Protein Information
| Accession | Q9Y4W6 |
|---|---|
| Protein Names | Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein) |
| Gene Symbol | AFG3L2 |
| Organism | Homo sapiens (Human) |
| Length | 797 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29733200 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAHRCLRLWG11RGGCWPRGLQ21QLLVPGGVGP31GEQPCLRTLY41RFVTTQARAS
51-10051RNSLLTDIIA61AYQRFCSRPP71KGFEKYFPNG81KNGKKASEPK91EVMGEKKESK
101-150101PAATTRSSGG111GGGGGGKRGG121KKDDSHWWSR131FQKGDIPWDD141KDFRMFFLWT
151-200151ALFWGGVMFY161LLLKRSGREI171TWKDFVNNYL181SKGVVDRLEV191VNKRFVRVTF
201-250201TPGKTPVDGQ211YVWFNIGSVD221TFERNLETLQ231QELGIEGENR241VPVVYIAESD
251-300251GSFLLSMLPT261VLIIAFLLYT271IRRGPAGIGR281TGRGMGGLFS291VGETTAKVLK
301-350301DEIDVKFKDV311AGCEEAKLEI321MEFVNFLKNP331KQYQDLGAKI341PKGAILTGPP
351-400351GTGKTLLAKA361TAGEANVPFI371TVSGSEFLEM381FVGVGPARVR391DLFALARKNA
401-450401PCILFIDEID411AVGRKRGRGN421FGGQSEQENT431LNQLLVEMDG441FNTTTNVVIL
451-500451AGTNRPDILD461PALLRPGRFD471RQIFIGPPDI481KGRASIFKVH491LRPLKLDSTL
501-550501EKDKLARKLA511SLTPGFSGAD521VANVCNEAAL531IAARHLSDSI541NQKHFEQAIE
551-600551RVIGGLEKKT561QVLQPEEKKT571VAYHEAGHAV581AGWYLEHADP591LLKVSIIPRG
601-650601KGLGYAQYLP611KEQYLYTKEQ621LLDRMCMTLG631GRVSEEIFFG641RITTGAQDDL
651-700651RKVTQSAYAQ661IVQFGMNEKV671GQISFDLPRQ681GDMVLEKPYS691EATARLIDDE
701-750701VRILINDAYK711RTVALLTEKK721ADVEKVALLL731LEKEVLDKND741MVELLGPRPF
751-797751AEKSTYEEFV761EGTGSLDEDT771SLPEGLKDWN781KEREKEKEEP791PGEKVAN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.04
|
|
| 14 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.94
|
| 35 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.97
|
|
| 66 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.78
|
|
| 313 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.87
|
|
| 402 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.95
Deep-Palm: 0.98
|
|
| 525 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 626 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.89
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
2
LNCaP
Specificity: 0.400
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.400
2/2 (100.0%)
1
frontal cortex
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 106 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 468 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |