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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9Y4W6 AFG3L2 Mitochondrial inner membrane m-AAA protease … Homo sapiens (Human) 797 aa

Protein Details: Q9Y4W6 (AFG3L2)

Protein Information
Accession Q9Y4W6
Protein Names Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein)
Gene Symbol AFG3L2
Organism Homo sapiens (Human)
Length 797 aa
Isoforms No isoforms
Related PMIDs 26876311 29733200 31251020
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.686
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
24
LNCaP cells
Specificity: 0.686
24/46 (52.2%)
10
HAP1 cells
Specificity: 0.286
10/10 (100.0%)
1
Prefrontal cortex
Specificity: 0.029
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAHRCLRLWG11RGGCWPRGLQ21QLLVPGGVGP31GEQPCLRTLY41RFVTTQARAS
51-10051RNSLLTDIIA61AYQRFCSRPP71KGFEKYFPNG81KNGKKASEPK91EVMGEKKESK
101-150101PAATTRSSGG111GGGGGGKRGG121KKDDSHWWSR131FQKGDIPWDD141KDFRMFFLWT
151-200151ALFWGGVMFY161LLLKRSGREI171TWKDFVNNYL181SKGVVDRLEV191VNKRFVRVTF
201-250201TPGKTPVDGQ211YVWFNIGSVD221TFERNLETLQ231QELGIEGENR241VPVVYIAESD
251-300251GSFLLSMLPT261VLIIAFLLYT271IRRGPAGIGR281TGRGMGGLFS291VGETTAKVLK
301-350301DEIDVKFKDV311AGCEEAKLEI321MEFVNFLKNP331KQYQDLGAKI341PKGAILTGPP
351-400351GTGKTLLAKA361TAGEANVPFI371TVSGSEFLEM381FVGVGPARVR391DLFALARKNA
401-450401PCILFIDEID411AVGRKRGRGN421FGGQSEQENT431LNQLLVEMDG441FNTTTNVVIL
451-500451AGTNRPDILD461PALLRPGRFD471RQIFIGPPDI481KGRASIFKVH491LRPLKLDSTL
501-550501EKDKLARKLA511SLTPGFSGAD521VANVCNEAAL531IAARHLSDSI541NQKHFEQAIE
551-600551RVIGGLEKKT561QVLQPEEKKT571VAYHEAGHAV581AGWYLEHADP591LLKVSIIPRG
601-650601KGLGYAQYLP611KEQYLYTKEQ621LLDRMCMTLG631GRVSEEIFFG641RITTGAQDDL
651-700651RKVTQSAYAQ661IVQFGMNEKV671GQISFDLPRQ681GDMVLEKPYS691EATARLIDDE
701-750701VRILINDAYK711RTVALLTEKK721ADVEKVALLL731LEKEVLDKND741MVELLGPRPF
751-797751AEKSTYEEFV761EGTGSLDEDT771SLPEGLKDWN781KEREKEKEEP791PGEKVAN
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
5 Prediction (Medium) - -
14 CYSMODDB SWISSPALM DBPTM Prediction (Medium) - -
35 Prediction (Medium) - -
66 Prediction (High) - -
313 Prediction (Medium) - -
402 Prediction (High) - -
525 Prediction (Medium) - -
626 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
106 R → C 0.001887 SNP Missense Mutation UCEC
468 R → C 0.001887 SNP Missense Mutation UCEC