Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q9Y6C9 | MTCH2 | Mitochondrial carrier homolog 2 (Met-induced … | Homo sapiens (Human) | 303 aa |
Protein Details: Q9Y6C9 (MTCH2)
Protein Information
| Accession | Q9Y6C9 |
|---|---|
| Protein Names | Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein) |
| Gene Symbol | MTCH2 |
| Organism | Homo sapiens (Human) |
| Length | 303 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MADAASQVLL11GSGLTILSQP21LMYVKVLIQV31GYEPLPPTIG41RNIFGRQVCQ
51-10051LPGLFSYAQH61IASIDGRRGL71FTGLTPRLCS81GVLGTVVHGK91VLQHYQESDK
101-150101GEELGPGNVQ111KEVSSSFDHV121IKETTREMIA131RSAATLITHP141FHVITLRSMV
151-200151QFIGRESKYC161GLCDSIITIY171REEGILGFFA181GLVPRLLGDI191LSLWLCNSLA
201-250201YLVNTYALDS211GVSTMNEMKS221YSQAVTGFFA231SMLTYPFVLV241SNLMAVNNCG
251-300251LAGGCPPYSP261IYTSWIDCWC271MLQKEGNMSR281GNSLFFRKVP291FGKTYCCDLK
301-303301MLI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 49 | SWISSPALM DBPTM CYSMODDB | MITOCHONDRIAL CARRIER HOMOLOG |
HeLa
(29575903)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.77
Deep-Palm: 0.90
|
| 79 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.85
Deep-Palm: 0.98
|
| 160 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.80
|
|
| 163 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.95
|
|
| 196 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.98
|
|
| 249 | - | - | - |
Deep-Palm: 0.64
|
|
| 255 | - | - | - |
Deep-Palm: 0.06
|
|
| 268 | - | - | - |
Deep-Palm: 0.06
|
|
| 270 | - | - | - |
Deep-Palm: 0.07
|
|
| 296 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.02
|
|
| 297 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
4
LNCaP
Specificity: 0.211
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.211
4/4 (100.0%)
3
PC3
Specificity: 0.158
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.105
2/2 (100.0%)
2
293T cell
Specificity: 0.105
2/2 (100.0%)
1
heart
Specificity: 0.053
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.158
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 49 | C → R | 0.001969 | SNP | Missense Mutation | HNSC |
| 57 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 60 | H → delinsLSGFFCYALN | 0.002506 | INS | In Frame Ins | COAD |
| 62 | A → Cfs*29 | 0.003460 | INS | Frame Shift Ins | CESC |
| 68 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 131 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 160 | C → R | 0.002976 | SNP | Missense Mutation | KIRC |
| 170 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 185 | R → C | 0.003460 | SNP | Missense Mutation | CESC |