Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q9Z0F8 Adam17 Disintegrin and metalloproteinase domain-containing protein … Mus musculus (Mouse) 827 aa

Protein Details: Q9Z0F8 (Adam17)

Protein Information
AccessionQ9Z0F8
Protein NamesDisintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
Gene SymbolAdam17
OrganismMus musculus (Mouse)
Length827 aa
IsoformsNo isoforms
Related PMIDs 29217618 31772009
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MRRRLLILTT11LVPFVLAPRP21PEEAGSGSHP31RLEKLDSLLS41DYDILSLANI
51-10051QQHSIRKRDL61QSATHLETLL71TFSALKRHFK81LYLTSSTERF91SQNLRVVVVD
101-150101GKEESEYSVK111WQNFFSGHVV121GEPDSRVLAH131IGDDDVTVRI141NTDGAEYNVE
151-200151PLWRFVNDTK161DKRMLVYKSE171DIKDFSRLQS181PKVCGYLNAD191SEELLPKGLI
201-250201DREPSEEFVR211RVKRRAEPNP221LKNTCKLLVV231ADHRFYKYMG241RGEESTTTNY
251-300251LIELIDRVDD261IYRNTSWDNA271GFKGYGVQIE281QIRILKSPQE291VKPGERHFNM
301-350301AKSFPNEEKD311AWDVKMLLEQ321FSFDIAEEAS331KVCLAHLFTY341QDFDMGTLGL
351-400351AYVGSPRANS361HGGVCPKAYY371NPTVKKNIYL381NSGLTSTKNY391GKTILTKEAD
401-450401LVTTHELGHN411FGAEHDPDGL421AECAPNEDQG431GKYVMYPIAV441SGDHENNKMF
451-500451SNCSKQSIYK461TIESKAQECF471QERSNKVCGN481SRVDEGEECD491PGIMYLNNDT
501-550501CCNSDCTLKP511GVQCSDRNSP521CCKNCQFETA531QKKCQEAINA541TCKGVSYCTG
551-600551NSSECPPPGD561AEDDTVCLDL571GKCKAGKCIP581FCKREQELES591CACVDTDNSC
601-650601KVCCRNLSGP611CVPYVDAEQK621NLFLRKGKPC631TVGFCDMNGK641CEKRVQDVIE
651-700651RFWDFIDQLS661INTFGKFLAD671NIVGSVLVFS681LIFWIPFSIL691VHCVDKKLDK
701-750701QYESLSLFHH711SNIEMLSSMD721SASVRIIKPF731PAPQTPGRLQ741ALQPAAMMPP
751-800751VPAAPKLDHQ761RMDTIQEDPS771TDSHADDDGF781EKDPFPNSST791AAKSFEDLTD
801-827801HPVTRSEKAA811SFKLQRQSRV821DSKETEC
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
184 - - -
Deep-Palm: 0.96
225 - - -
Deep-Palm: 0.90
333 - - -
Deep-Palm: 0.82
365 - - -
Deep-Palm: 0.47
423 - - -
Deep-Palm: 0.16
453 - - -
Deep-Palm: 0.24
469 - - -
Deep-Palm: 0.43
478 - - -
Deep-Palm: 0.20
489 - - -
Deep-Palm: 0.03
501 - - -
Deep-Palm: 0.03
502 - - -
Deep-Palm: 0.03
506 - - -
Deep-Palm: 0.03
514 - - -
Deep-Palm: 0.04
521 - - -
Deep-Palm: 0.07
522 - - -
Deep-Palm: 0.07
525 - - -
Deep-Palm: 0.07
534 - - -
Deep-Palm: 0.04
542 - - -
Deep-Palm: 0.12
548 - - -
Deep-Palm: 0.10
555 - - -
Deep-Palm: 0.08
567 - - -
Deep-Palm: 0.50
573 - - -
Deep-Palm: 0.70
578 - - -
Deep-Palm: 0.45
582 - - -
Deep-Palm: 0.41
591 - - -
Deep-Palm: 0.04
593 - - -
Deep-Palm: 0.06
600 - - -
Deep-Palm: 0.05
603 - - -
Deep-Palm: 0.07
604 - - -
Deep-Palm: 0.05
611 - - -
Deep-Palm: 0.31
630 - - -
Deep-Palm: 0.59
635 - - -
Deep-Palm: 0.49
641 - - -
Deep-Palm: 0.08
693 - - -
Deep-Palm: 0.73
827 - - -
GPS-Palm: 0.92
Deep-Palm: 0.03
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
Raw 264.7
Specificity: 0.500
1/1 (100.0%)
1
NSC
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine