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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
S4R3Z2 AKR1C3 Aldo-keto reductase family 1 member … Homo sapiens (Human) 300 aa

Protein Details: S4R3Z2 (AKR1C3)

Protein Information
AccessionS4R3Z2
Protein NamesAldo-keto reductase family 1 member C3 (Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), isoform CRA_a)
Gene SymbolAKR1C3
OrganismHomo sapiens (Human)
Length300 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MQISQVPRSK11ALEVTKLAIE21AGFRHIDSAH31LYNNEEQVGL41AIRSKIADGS
51-10051VKREDIFYTS61KLWSTFHRPE71LVRPALENSL81KKAQLDYVDL91YLIHSPMSLK
101-150101PGEELSPTDE111NGKVIFDIVD121LCTTWEAMEK131CKDAGLAKSI141GVSNFNRRQL
151-200151EMILNKPGLK161YKPVCNQVEC171HPYFNRSKLL181DFCKSKDIVL191VAYSALGSQR
201-250201DKRWVDPNSP211VLLEDPVLCA221LAKKHKRTPA231LIALRYQLQR241GVVVLAKSYN
251-300251EQRIRQNVQV261FEFQLTAEDM271KAIDGLDRNL281HYFNSDSFAS291HPNYPYSDEY
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
122 - - -
GPS-Palm: 0.74
Deep-Palm: 0.85
131 - - -
Deep-Palm: 0.64
165 - - -
Deep-Palm: 0.55
170 - - -
Deep-Palm: 0.40
183 SWISSPALM DBPTM CYSMODDB Aldo/keto reductase family - -
GPS-Palm: 0.77
Deep-Palm: 0.91
219 - - -
GPS-Palm: 0.89
Deep-Palm: 0.98
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
47 R → C 0.001887 SNP Missense Mutation UCEC
87 S → C 0.003559 SNP Missense Mutation KIRP
154 C → F 0.001014 SNP Missense Mutation BRCA
170 R → C 0.001764 SNP Missense Mutation LUAD
170 R → C 0.003559 SNP Missense Mutation KIRP
193 C → R 0.002747 SNP Missense Mutation LIHC
276 R → C 0.001887 SNP Missense Mutation UCEC