Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| V9GZ37 | HSPA1A | Heat shock protein family A … | Homo sapiens (Human) | 476 aa |
Protein Details: V9GZ37 (HSPA1A)
Protein Information
| Accession | V9GZ37 |
|---|---|
| Protein Names | Heat shock protein family A (Hsp70) member 1A |
| Gene Symbol | HSPA1A |
| Organism | Homo sapiens (Human) |
| Length | 476 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 31251020 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAKAAAIGID11LGTTYSCVGV21FQHGKGERNV31LIFDLGGGTF41DVSILTIDDG
51-10051IFEVKATAGD61THLGGEDFDN71RLVNHFVEEF81KRKHKKDISQ91NKRAVRRLRT
101-150101ACERAKRTLS111SSTQASLEID121SLFEGIDFYT131SITRARFEEL141CSDLFRSTLE
151-200151PVEKALRDAK161LDKAQIHDLV171LVGGSTRIPK181VQKLLQDFFN191GRDLNKSINP
201-250201DEAVAYGAAV211QAAILMGDKS221ENVQDLLLLD231VAPLSLGLET241AGGVMTALIK
251-300251RNSTIPTKQT261QIFTTYSDNQ271PGVLIQVYEG281ERAMTKDNNL291LGRFELSGIP
301-350301PAPRGVPQIE311VTFDIDANGI321LNVTATDKST331GKANKITITN341DKGRLSKEEI
351-400351ERMVQEAEKY361KAEDEVQRER371VSAKNALESY381AFNMKSAVED391EGLKGKISEA
401-450401DKKKVLDKCQ411EVISWLDANT421LAEKDEFEHK431RKELEQVCNP441IISGLYQGAG
451-476451GPGPGGFGAQ461GPKGGSGSGP471TIEEVD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 17 | ATPase, nucleotide binding domain | - | - |
Deep-Palm: 0.96
|
|
| 102 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 141 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 409 | - | - | - |
Deep-Palm: 0.92
|
|
| 438 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.78
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
cerebral cortex
Specificity: 0.500
3/3 (100.0%)
2
Jurkat T cell
Specificity: 0.333
2/2 (100.0%)
1
LNCaP
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 626 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |