Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| X6R3U4 | PLEKHH3 | Pleckstrin homology domain-containing family H … | Homo sapiens (Human) | 790 aa |
Protein Details: X6R3U4 (PLEKHH3)
Protein Information
| Accession | X6R3U4 |
|---|---|
| Protein Names | Pleckstrin homology domain-containing family H member 3 |
| Gene Symbol | PLEKHH3 |
| Organism | Homo sapiens (Human) |
| Length | 790 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 1.000
36/46 (78.3%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MPLPGGLWWL11LCCRRGFTLL21HRDYGDGELS31GDGDEDEDEE41TFELRTPSPA
51-10051GGGRGPLEVT61LTQPVRSGPV71SNRLQSWEET81WSLIPEKGLP91EDDPDIVVKG
101-150101WLYREPRGGG111ARPWLPPRRA121WFVLTRDSLD131QFSSSGKGAR141RLGSLVLTSL
151-200151CSVTGPERRR161KETGLWSVTV171SGRKHSVRLC181SPRQAEAERW191GVALREVIAS
201-250201KAPLETPTQL211LLRDIQESCG221DPEAVALIYL231RNPILRHTSG241ALYAPLLPLP
251-300251YGVSAPGPGY261APLREEAVRL271FLALQALEGA281RRPGPLMQGV291LQTCRDLPAL
301-350301RDELFLQLAK311QTSGPAGPPG321LPATQDPAAL331RYWQLLTCMS341CTFRPGGAVR
351-400351GHLLGHLERT361EQALPDSELA371EYARFIRKAL381GRTRGRELVP391SLAEISALSQ
401-450401RQELLCTVHC411PGAGACAVAI421DSHTTAGEVA431RELVGRLGLA441RSRNAFALYE
451-500451QRGAQERALA461GGTLVADVLT471SLAAEEAGLE481DSPDSGWRLC491LRLHGPLHPE
501-550501GLSPDGHELP511FLFEQAHALL521LRGRPPPPDD531TLRALAALRL541QSLQRDFSPR
551-600551VPLPRLDRLL561PPPAPPREDP571PRPTPRPPPS581AALLAGALWS591PGLAKRRAER
601-650601ARRGGAGRTA611GSIAREGGGG621AGTAAAVLGG631WKRLRGMGRA641EAMAAYLALA
651-700651AQCPGFGAAR661YDVLELSTEP671GRGAPQKLCL681GLGAKAMSLS691RPGETEPIHS
701-750701VSYGHVAACQ711LMGPHTLALR721VGESQLLLQS731PQVEEIMQLV741NAYLANPSPE
751-790751RPCSSSSPPC761QDLPDTSPPS771QRPGLDEPQG781QSGCLGQLQD
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 12 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | - | 29575903 |
| 13 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | - | 29575903 |
| 151 | Prediction (High) | - | - |
| 180 | Prediction (Medium) | - | - |
| 294 | Prediction (Low) | - | - |
| 338 | Prediction (High) | - | - |
| 341 | Prediction (Medium) | - | - |
| 410 | Prediction (Low) | - | - |
| 653 | Prediction (High) | - | - |
| 679 | Prediction (High) | - | - |
| 784 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 189 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 516 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 757 | S → C | 0.002288 | SNP | Missense Mutation | STAD |