🔍 Protein Search

Mutation Gene Search

Search Guide
Search Types:
  • Protein Search: Search by protein accession or gene symbol
  • Mutation Gene Search: Search by mutation gene names
Mutation Types:
  • CNV Amplification: Copy number variation - gene amplification
  • CNV Deletion: Copy number variation - gene deletion
  • Hotspot Gene: Genes with mutation hotspots
  • SNV: Single nucleotide variations
How to use:
  1. Enter mutation gene name (base gene name)
  2. Optionally select specific mutation type
  3. Click search to view results
  4. View detailed charts by clicking "View Chart"
  5. Use pagination to browse through results
Significance Interpretation:
  • Positive correlation: Palmitoylation increases mutation probability (Coefficient > 0, adjust P (Logit) < 0.05)
  • Negative correlation: Palmitoylation decreases mutation probability (Coefficient < 0, adjust P (Logit) < 0.05)
  • Not significant: No significant association (adjust P (Logit) ≥ 0.05)
New Feature: Click on protein accession links to view detailed protein information including sequence, palmitoylation sites, and related publications.
Gene Name Matching: This search uses prefix matching. For example, searching "TP53" will match "TP53_M1863", "TP53_R273H", "TP53_xxx", etc.
Note: Results are filtered by Fisher's exact test P-value < 0.05 and sorted by adjust P Logit and Fisher. All results undergo FDR correction for multiple testing.
Statistical Model:
  • Formula: log(odds of mutation) = β₀ + β₁ × palmitoylation_status + β₂ × PC1 + β₃ × PC2
  • β₁ (Coefficient): Effect of palmitoylation on mutation probability
  • PC1, PC2: Principal components controlling for cell line batch effects
  • Method: Firth logistic regression for small sample sizes
Tip: Enter the base gene name without specific mutation suffixes. The system will match all variants.
Ready to Search

Please enter a mutation gene name and optionally select a mutation type to search.